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#85129 - 03/09/04 07:14 AM Codeine Phosphate
Melody Administrator Offline
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Registered: 03/20/03
Posts: 1498
Loc: DrugBuyers.Com
Codeine is an alkaloid obtained from opium or prepared from morphine by methylation and occurs as white crystals. Codeine effloresces slowly in dry air and is effected by light. The chemical name of codeine phosphate is 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol phosphate (1:1)(salt) hemihydrate and has the empirical formula of C18H21NO3·H3PO4·1/2H20. Its molecular weight is 406.4.

Each soluble tablet contains 30 mg (0.074 mmol) or 60 mg (0.15 mmol) of codeine phosphate. These tablets also contain lactose and sucrose.

Soluble tablets of codeine phosphate are freely soluble in water. They are intended for the preparation of solutions for parenteral administration. These tablets are not sterile. Codeine phosphate is an analgesic.


INDICATIONS

Codeine phosphate is an analgesic indicated for the relief of mild to moderate pain.


DOSAGE AND ADMINISTRATION

For Analgesia: Dosage should be adjusted according to the severity of the pain and the response of the patient.

Adults: 15 to 60 mg every 4 to 6 hours (usual adult dose, 30 mg).

Children: 1 Year of Age and Older - 0.5 mg/kg of b.d. weight or 15 mg/m2 of b.d. surface every 4 to 6 hours.

Soluble tablets codeine phosphate are administered subcutaneously or intramuscularly.

Solutions for injection should be prepared with sterile water and filtered through a 0.22 membrane filter.

Note: Do not use the solution if it is more than slightly discolored or contains a precipitate.


PATIENT INFORMATION

Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics, phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.

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#85130 - 12/23/04 08:24 AM Re: Codeine Phosphate
nikkicat Offline
Newbie


Registered: 11/30/04
Posts: 45
Whats the difference between codeine phosphate and codeine sulphate?

thanks!

nikki

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#85131 - 12/23/04 12:37 PM Re: Codeine Phosphate
rockystuart Offline
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Registered: 03/11/04
Posts: 237
Loc: San Fran Bay Area, Calif
There is not too much difference between the phosphate and sulphate. The phospate will be slightly weaker on a mg to mg basis because the base molicule weighs more than the sulpher. It's strange but morphine is usually done as a sulphate and codeine is done as a PHOSPATE.
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#85132 - 01/24/05 05:59 AM Re: Codeine Phosphate
anxious100 Offline
Member


Registered: 11/24/04
Posts: 156
I find this to be the best asthma medication there is, I know it's not commonly found on Western markets, but having purchased Codine Sulphate in France and taken it at times when I have asthma issues (which is very often), it's been a great help to me.
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#85133 - 02/01/05 05:08 PM Re: Codeine Phosphate
nikkicat Offline
Newbie


Registered: 11/30/04
Posts: 45
How much tynenol doesezch tylenol 4 have in it? It says the 60 mg of codeine but does not indicate amount of codeine.I ussually take norco 10/325 but has to switch to the tynenol 4 for a bit to decrease tolerance to the hydro codone. It is not as strong but it keeps the pain at bay just concerned about the amount of tylenol. Anybody know? I even researched it and could not find the answer!
Thanks!

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#85134 - 02/01/05 06:14 PM Re: Codeine Phosphate
CARLITOS_WAY Offline
Threadhead


Registered: 06/27/04
Posts: 789
Loc: WASHINGTON, USA
Quote:

How much tynenol doesezch tylenol 4 have in it? It says the 60 mg of codeine but does not indicate amount of codeine.I ussually take norco 10/325 but has to switch to the tynenol 4 for a bit to decrease tolerance to the hydro codone. It is not as strong but it keeps the pain at bay just concerned about the amount of tylenol. Anybody know? I even researched it and could not find the answer!
Thanks!




300 mg of Tylenol (APAP)
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#85135 - 02/01/05 06:25 PM Re: Codeine Phosphate
JethroBodine Offline
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Registered: 06/20/03
Posts: 333
Loc: Ozark Mountains
Codeine Phosphate (C18 H21 NO3). H3PO4 . 1 1/2 H2O mw424
Codeine Sulfate (C18 H21 NO3)2 . H2SO4 . 5H2O mw786

per molecule of codeine base, the phosphate is 8% heavier. Therefore in a mass comparison, the sulfate is a little stronger. If you can accurately cut your pills into 12 parts, you could make up for it.
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#85136 - 02/02/05 03:15 AM Re: Codeine Phosphate
Lablady2 Offline
Banned. Shill. Found out to be Mod and working for OP4L


Registered: 05/05/04
Posts: 508
Loc: New York City
Chemistry major???? I rarely see someone post re molecular weights and chemical composition on this board - and you live in the Ozarks???? Just teasing - couldn't resist:) I really enjoy your posts - you are a very knowledgable person!
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#85137 - 04/29/05 02:13 AM Re: Codeine Phosphate
grix Offline
Journeyman


Registered: 04/10/05
Posts: 63
Anyone have a rough idea of the comparative narcotic strength of Codeine to Hydrocodone or vice-versa? For example, how many Tylenol #3 30 mg codeine would equal 1 Hydro 10/325? Thanks.
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#85138 - 04/30/05 03:38 AM Re: Codeine Phosphate
bc3 Offline
Stranger


Registered: 03/08/05
Posts: 7
Yes.... used to take hydro 10/325 in us. cannot get in europe. takes 60-90mg of codeine to even come close for me... truth is it is good but not as good... doesn't last as long either. But it's all I can get and it works. Sorry can't give exact details for you just from experience. Bye!
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#85139 - 04/30/05 04:08 AM Re: Codeine Phosphate
CARLITOS_WAY Offline
Threadhead


Registered: 06/27/04
Posts: 789
Loc: WASHINGTON, USA
Codiene has a shorter half life. It also has less sedative effect. mg to mg it's suppose to be 8 to 1.
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#85140 - 04/30/05 06:42 AM Re: Codeine Phosphate
theborg Offline
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Registered: 10/20/02
Posts: 590
Loc: New England
Quote:

Anyone have a rough idea of the comparative narcotic strength of Codeine to Hydrocodone or vice-versa? For example, how many Tylenol #3 30 mg codeine would equal 1 Hydro 10/325? Thanks.




Don't know how accurate this is but here's a converter for you.
http://www.medcalc.com/narcotics.html
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#85141 - 05/26/05 01:30 PM Re: Codeine Phosphate
vertigok Offline
Stranger


Registered: 03/22/05
Posts: 9
there isn't really a comparison
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#85142 - 07/20/05 02:26 PM Re: Codeine Phosphate
NVR2L8 Offline
Member


Registered: 03/12/05
Posts: 111
Loc: TX
Had to get Tylenol 3 due to it being so much cheaper than Hydro. How much to compare and also, has anyone noticed upset stomach on it, more so than hydro.

Thanks,
ME
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#85143 - 08/31/05 01:07 PM Re: Codeine Phosphate
dtyler Offline
Stranger


Registered: 08/11/05
Posts: 1
Codeine works great in the treatment of narcolepsy. It has a paradoxel effect, it helps to keep narcoleptics awake without the side effects that ritalyn has.
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#85144 - 10/11/05 01:13 PM Re: Codeine Phosphate
shovelhead Offline
Pooh-Bah


Registered: 09/22/05
Posts: 1200
if you wanna get down down on the ground use 50mg codine but don't forget this fact 'you can't get it back codine'
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#85145 - 10/12/05 01:17 PM Re: Codeine Phosphate
trixiestixxx Offline
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Registered: 08/16/05
Posts: 390
What?
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#85146 - 10/15/05 10:09 PM Re: Codeine Phosphate
charon666 Offline
Enthusiast


Registered: 05/16/05
Posts: 242
just be cautious. i believe it is a schedule II med as just plain codeine, but when one purchases it with the tylenol, it drops to a schedule III.
for emergency, codeine is imperative in terms of bronchitis (only take at night to sleep;if one takes it to suppress cough all day, then one can develop pneumonia,) and is better for headaches/migraines than hydro which can worsen headaches in some [but not as good as butalbital, with or without the codeine for headaches/migraines.] If one can get the tylenol #4, 60 mg. codeine, then break in half, one has double the pills of tylenol #3. This does help with pain, but will not give certain effects (at least I don't believe it will) that some people anticipated from the hydro. Another pain killer is talwin, pentazocine,sosegon, schedule IV with tylenol, and it does work, particularly on dental pain. both are cheaper and but for the codeine cough syrup mentioned in the NDS indictment, are under less scrutiny at present.

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#85147 - 10/16/05 09:58 PM Re: Codeine Phosphate
MicSlyness Offline
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Registered: 08/12/05
Posts: 2255
Loc: Water Closet
It is scheduled by the amount of codeine, I don't have the link in front of me, but you can find out....I think one of the links on the DB page will direct you to the scheduling page and it breaks it down so it's easy to read.
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#85148 - 10/16/05 11:33 PM Re: Codeine Phosphate
osawa Offline
Journeyman


Registered: 09/29/05
Posts: 52
Codeine’s comparative analgesia to hydro is 6/1

So 60mg codeine = 10 mg hydro

Duration of hydro may be up to 2 hours longer than codeine

Just google opioid equivalency chart and you'll see where I'm getting this info.

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#85149 - 11/02/05 05:07 AM Re: Codeine Phosphate
makranger13 Offline
Stranger


Registered: 09/13/05
Posts: 6
Things that Potentiate Codeine (/Enhance Experience):

-DXM/ketamine (therapeutic amount, ie. Amount normally taken for cough)
-wine - white, not red (small amount) or brandy/rum/vodka
-antihistamines ie.benadryl (25-75mg), original Dramamine,Phenyltoloxamine Citrate (2x therapeutic dose)
-antacids ie. Sodium bicarbonate mixed into narcotic solution
-benzodiazapines (therapeutic dose)
-belladona alkaloids - scopolamine especially (therapeutic dose)
-Nyquil mix (due to DXM and doxylamine)
-St Johns Wort

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#85150 - 12/22/05 08:51 PM Re: Codeine Phosphate
Xiola Offline
Stranger


Registered: 06/01/05
Posts: 1
Please help! I got codeine phosphate and the description says that it's water soluble. I was under the impression that I was to drink it like Alka-Seltzer, but now that I've been online it seems like it's for injection use only. Is this true? Can you not drink a water soluble codeine phosphate tablet? I'm so confused. And I don't really have the means to do it any other way. If anyone has the proper info on this matter, please help! Thanks.
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#85151 - 12/22/05 10:07 PM Re: Codeine Phosphate
blueeyes Offline
Pooh-Bah


Registered: 04/27/05
Posts: 1401
whats the name of the codeine product.
The UK has several that are like alka seltzer
one call soldapiene (sp?) comes to mind

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#85152 - 01/16/06 12:19 PM Re: Codeine Phosphate
toe Offline
GRAND Pooh-Bah


Registered: 10/09/02
Posts: 1652
Loc: MidWest USA
Wow. I hope you didn't do this. Codeine comes in effervescent tabs that are meant to be dissolved in liquid and drunk.

Injecting codeine can kill you. Seriously. Pulmonary embolism, badda-boom!
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#85153 - 01/16/06 02:58 PM Re: Codeine Phosphate
blueeyes Offline
Pooh-Bah


Registered: 04/27/05
Posts: 1401
INTRAVENOUS injection of codiene can cause pulmonary edema
but injection sc (sub cutaneous just under the skin) or IM
injection (into the butt thigh or upper arm) can be & is given in that manner, IM & SC routes.

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#85154 - 02/20/06 10:30 PM Re: Codeine Phosphate
aceyalone Offline
Enthusiast


Registered: 11/21/05
Posts: 234
Quote:

if you wanna get down down on the ground use 50mg codine but don't forget this fact 'you can't get it back codine'




ok, ok.......WHAT!?!?!?!?!?

No idea what yer post means, but it sounds like a good ole time!

ACE

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#85155 - 03/03/06 09:36 AM Re: Codeine Phosphate
janey Offline
Pooh-Bah


Registered: 01/12/03
Posts: 1024
Loc: new england
Quote:

Had to get Tylenol 3 due to it being so much cheaper than Hydro. How much to compare and also, has anyone noticed upset stomach on it, more so than hydro.

Thanks,
ME




upset stomach for me,yes,yes,yes........codeine feels very heavy in my belly. I never noticed this years back, but for some reason now I notice that it makes me pretty nauseous........is there anything that can be taken to help with that?

solpadeine is OTC in the UK, and it is to be tasken as alka seltzer....definately NOT intended to be injected, but I'm not sure if that's even the product in question........
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#85156 - 03/06/06 10:39 AM Re: Codeine Phosphate
BBM Offline
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Registered: 12/19/03
Posts: 215
Loc: I'm right here! Do you see me?
Hello all,

Has anybody here know what this is exactly? Is it a pill to be taken orally or disolved in a liquid?

Codeine/paracetamol (COD-Efferalgan) 30/500 mg

Thanks,

BBM
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#85157 - 03/08/06 10:25 AM Re: Codeine Phosphate
janey Offline
Pooh-Bah


Registered: 01/12/03
Posts: 1024
Loc: new england
sounds like one of the products sold OTC in New Zealand. I'v never taken it, but have seen it listed on a product page w/ Nurpfen+ and the likes..........I'm assuming you swallow it like any regular pill. Something that's meant to be dissolved, such as Solpadeine, states so clearly in the product literature.
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Anytime I see something screech across a room and latch onto someone's neck, and the guy screams and tries to get it off, I have to laugh, because what IS that thing?!-Jack Handey

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#85158 - 03/23/06 09:19 PM Re: Codeine Phosphate
SeaAngel24 Offline
Stranger


Registered: 03/13/06
Posts: 18
Loc: Some beach, somewhere~!~
My Doc has had me on T3's for cluster headaches for about 3 months, I have developed a very high tolerance to the codeine and was wondering how much codeine is safe to take in one single dose????

Thanks
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