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#81118 - 03/01/04 09:31 AM
Valium - Diazepam
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Melody
Moderator
Pooh-Bah
Registered: 03/20/03
Posts: 1498
Loc: DrugBuyers.Com
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Valium (Diazepam)
Diazepam is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
In acute alcohol withdrawal, diazepam may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis.
As an adjunct prior to endoscopic procedures if apprehension, anxiety or acute stress reactions are present, and to diminish the patient's recall of the procedures (see WARNINGS).
Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints, or secondary to trauma); spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia); athetosis; stiff-man syndrome; and tetanus.
Injectable diazepam is a useful adjunct in status epilepticus and severe recurrent convulsive seizures.
Diazepam is a useful premedication (for injectable solution only, the IM route is preferred) for relief of anxiety and tension in patients who are to undergo surgical procedures. Intravenously, prior to cardioversion for the relief of anxiety and tension and to diminish the patient's recall of the procedure.
WARNINGS
When used intravenously, the following procedures should be undertaken to reduce the possibility of venous thrombosis, phlebitis, local irritation, swelling, and, rarely, vascular impairment: diazepam should be injected slowly, taking at least one minute for each 5 mg (1 ml) given; do not use small veins, such as those on the dorsum of the hand or wrist; extreme care should be taken to avoid intra-arterial administration or extravasation (see CLINICAL PHARMACOLOGY).
Do not mix or dilute diazepam with other solutions or drugs in syringe or infusion container. If it is not feasible to administer diazepam directly IV, it may be injected slowly through the infusion tubing as close as possible to the vein insertion.
Extreme care must be used in administering injectable diazepam by the IV route to the elderly, to very ill patients and to those with limited pulmonary reserve because of the possibility that apnea and/or cardiac arrest may occur. Concomitant use of barbiturates, alcohol or other central nervous system depressants increases depression with increased risk of apnea. Resuscitative equipment including that necessary to support respiration should be readily available.
When diazepam is used with a narcotic analgesic, the dosage of the narcotic should be reduced by at least one-third and administered in small increments. In some cases the use of a narcotic may not be necessary.
Diazepam should not be administered to patients in shock, coma, or in acute alcoholic intoxication with depression of vital sins. As is true of most CNS-acting drugs, patients receiving diazepam should be cautioned against engaging in hazardous occupations requiring complete mental alertness, such as operating machinery or driving a motor vehicle.
Tonic status epilepticus has been precipitated in patients treated with IV diazepam for petit mal status or petit mal variant status.
Use in Pregnancy: An increased risk of congenital malformations associated with the use of minor tranquilizers (diazepam, meprobamate and chlordiazepoxide) during the first trimester of pregnancy has been suggested in several studies. Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. The possibility that a woman of childbearing potential may become pregnant at the time of institution of therapy should be considered. Patients should be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physicians about the desirability of discontinuing the drug.
In humans, measurable amounts of diazepam were found in maternal and cord blood, indicating placental transfer of the drug. Until additional information is available, diazepam injectable forms are not recommended for obstetrical use.
Pediatric Use: Efficacy and safety of parenteral diazepam has not been established in the neonate (30 days or less of age).
Prolonged central nervous system depression has been observed in neonates, apparently due to inability to biotransform diazepam into inactive metabolites.
In pediatric use, in order to obtain maximum clinical effect with the minimum amount of drug and thus to reduce the risk of hazardous side effects, such as apnea or prolonged periods of somnolence, it is recommended that the drug be given slowly over a three minute period in a dosage not to exceed 0.25 mg/kg. After an interval of 15 to 30 minutes the initial dosage can be safely repeated. If, however, relief of symptoms is not obtained after a third administration, adjunctive therapy appropriate to the condition being treated is recommended.
Withdrawal symptoms of the barbiturate type have occurred after the discontinuation of benzodiazepines (see DRUG ABUSE AND DEPENDENCE).
Additional Information for Injectable Emulsion: STRICT ASEPTIC TECHNIQUE MUST ALWAYS BE MAINTAINED DURING HANDLING. DIAZEPAM INJECTABLE EMULSION IS A SINGLE-USE PARENTERAL PRODUCT, CONTAINS NO ANTIMICROBIAL PRESERVATIVES, AND CAN SUPPORT RAPID GROWTH OF MICROORGANISMS. ALWAYS DISCARD UNUSED PORTION (SEE DOSAGE AND ADMINISTRATION, ASEPTIC GUIDELINES FOR PARENTERAL USE). THERE HAVE BEEN REPORTS IN WHICH FAILURE TO USE ASEPTIC TECHNIQUE WHEN HANDLING OTHER PARENTERAL PRODUCTS (CONTAINING THE SAME VEHICLE) WAS ASSOCIATED WITH MICROBIAL CONTAMINATION OF THE PRODUCT AND WITH FEVER, INFECTION/SEPSIS, OTHER LIFE THREATENING ILLNESSES, AND/OR DEATH. DO NOT USE IF CONTAMINATION IS SUSPECTED.
PRECAUTIONS
Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to readminister the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures.
If diazepam is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employed¾particularly with known compounds which may potentiate the action of diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants. In highly anxious patients with evidence of accompanying depression, particularly those who may have suicidal tendencies, protective measures may be necessary. The usual precautions in treating patients with impaired hepatic function should be observed. Metabolites of diazepam are excreted by the kidney; to avoid their excess accumulation, caution should be exercised in the administration to patients with compromised kidney function.
Since an increase in cough reflex and laryngospasm may occur with peroral endoscopic procedures, the use of a topical anesthetic agent and the availability of necessary countermeasures are recommended. Injectable forms of diazepam have produced hypotension or muscular weakness in some patients, particularly when used with narcotics, barbiturates or alcohol.
For Injectable Solution Only: Until additional information is available, injectable diazepam in not recommended for obstretical use.
Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.
The clearance of diazepam and certain other benzodiazepines can be delayed in association with cimetidine (Tagamet) administration. The clinical significance of this is unclear.
Labor and Delivery: For Injectable Emulsion Only: In humans, measurable amounts of diazepam were found in maternal and cord blood. indicating placental transfer of the drug. Until additional information is available, injectable diazepam is not recommended for obsterical use.
OVERDOSE
Management of Overdosage: Manifestations of diazepam overdosage include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored, as in all cases of drug overdosage, although, in general, these effects have been minimal following overdosage. General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of levarterenol (for injectable solution), norepinephrine (for injectable emulsion), or metaraminol (for either form). Dialysis is of limited value.
Additional Information for Injectable Solution: Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil monograph, including
CONTRAINDICATIONS
, WARNINGS, and PRECAUTIONS should be consulted prior to use.
CONTRAINDICATIONS
Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy. Injectable Emulsion Only: Because the diazepam emulsion vehicle contains soybean oil, diazepam injectable emulsion should not be used in patients with known hypersensitivity to soy protein.
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#81120 - 06/01/04 04:21 AM
Re: Valium - Diazepam
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nycalt
Veteran
Registered: 05/04/04
Posts: 647
Loc: Florida - Gulf Coast
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Quote:
Melody,
Can you tell me how long valium stays in your sytstem ??
Well, I'm not Melody, but I think I can answer your question for you.
Firstly, the half life for valium is about 12 - 18 hours, meaning half of the drug will be out of your system in that time. But, the thing with half lives, if you remember from chemistry, then the process starts all over again for the remainder. Meaning half of what remains will be out in another 15 hours or so, and so on.
So, it takes a lot longer than two half lives to eliminate a drug from your system.
It takes about seven half lives to totally eliminate any drug from your system. So, doing the math and assuming an average of 15 hour half live, it would take about 4 1/3 days (105 hours) to eliminate the drug totally.
Now, keep in mind however, this does not mean that Valium is effective for 4 days. The level required for therapeutic dose of most drugs is generally at most one half life, and even shorter if you’ve used the drug for a while and developed a tolerance to it.
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#81121 - 06/13/04 04:39 PM
Re: Valium - Diazepam
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MrOrange
Enthusiast
Registered: 12/18/01
Posts: 278
Loc: West
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According to the Clinical Handbook of Psychotropic Drugs, the half-life of Diazepam 5 mg is 30 to 200 hours. Check this site:
http://www.dr-bob.org/tips/bzd.html
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#81123 - 02/14/05 05:38 PM
Re: Valium - Diazepam
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dsmmcm
Veteran
Registered: 11/08/03
Posts: 694
Loc: southwest US
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Quote:
Firstly, the half life for valium is about 12 - 18 hours, meaning half of the drug will be out of your system in that time. But, the thing with half lives, if you remember from chemistry, then the process starts all over again for the remainder. Meaning half of what remains will be out in another 15 hours or so, and so on.
So, it takes a lot longer than two half lives to eliminate a drug from your system.
It takes about seven half lives to totally eliminate any drug from your system. So, doing the math and assuming an average of 15 hour half live, it would take about 4 1/3 days (105 hours) to eliminate the drug totally.
Now, keep in mind however, this does not mean that Valium is effective for 4 days. The level required for therapeutic dose of most drugs is generally at most one half life, and even shorter if you’ve used the drug for a while and developed a tolerance to it.
nycalt,
Your post is accurate and informative. Much of the on-line "literature" is total BS when it comes to half-lives. Some people quote the half-life of valium as 200 hours. If that were the case, and someone took 15 mg/day, they would be a total zombie in a week or so.
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#81124 - 02/14/05 05:41 PM
Re: Valium - Diazepam
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dsmmcm
Veteran
Registered: 11/08/03
Posts: 694
Loc: southwest US
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Quote:
According to the Clinical Handbook of Psychotropic Drugs, the half-life of Diazepam 5 mg is 30 to 200 hours. Check this site:
http://www.dr-bob.org/tips/bzd.html
The half-life of any drug is independent of the initial amount. Whether it's 1 mg or 1 gram, the half-life is the same. And your 200 hour half-life for valium is exactly what I was talking about in my last post. It cannot be accurate.
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#81137 - 08/21/05 07:49 PM
Re: Valium - Diazepam
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dsmmcm
Veteran
Registered: 11/08/03
Posts: 694
Loc: southwest US
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Quote:
Quote:
The half-life of any drug is independent of the initial amount. Whether it's 1 mg or 1 gram, the half-life is the same. And your 200 hour half-life for valium is exactly what I was talking about in my last post. It cannot be accurate.
Not true. The blood level of some drugs will affect their rate of metabolism. Codeine is a good example. Swamping the enzyme system puts a ceiling on its conversion to nor-morphine. Many other drugs affect the CYP system and their blood levels can either speed up or slow down their metabolism.
Metabolic halflife is not ruled by the laws of physics as is the case for radioactive decay. Metabolism of a drug in a living organism can be subject to complex interactions of enzyme systems affected by drug blood level or which can be overloaded as is the case for codeine.
You are correct about the published halflives of diazepam being much longer than its effective halflife.
What you say is more or less true, but largely irrelevant. You are confusing the rate of chemical reaction with the half-life. These are two totally different concepts, both of which are entirely dependent on the laws of chemistry, which are totally derivable from physics. Most metabolic reactions will display pseudo first order behavior in the recommended dosage range , because the substance being metabolized is present in very small amounts, and everything else is more or less constant over the timescale of the reaction. I can write the differential equations for you, if you are interested. Indeed, without a linear response it would be just about impossible to ever get dosages correct.
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#81138 - 09/05/05 10:07 AM
Valium and Soma
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oceanlover
Veteran
Registered: 05/15/05
Posts: 522
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I was going order from my ROP during my re-consult soon and also ask these questions, but did not want too look too dumb. I take Lortab for my pain for fibro, bulging discs and other pain. I am also in the need for a muscle relaxant and had read that Soma/carisoprodol is a good one and was also going to request that. Further I have been having severe anxiety for all of this pain trouble sleeping and other things going on in my life right now. I was going to ask for Valium (Diazepam) too but didn't know enough about meds to know what class they are in, types they are, and if all would be filled for me. Could someone with knowledge in this subject let me know before I make a complete fool of myself. I also hope I am able to get all of these or feel I may loose my mind from the pain I deal with everyday. I am also going to see someone and hopefully that will also help.
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#81139 - 09/05/05 02:53 PM
Re: Valium and Soma
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oceanlover
Veteran
Registered: 05/15/05
Posts: 522
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I was going order from my ROP during my re-consult soon and also ask these questions, but did not want too look too dumb. I take Lortab for my pain for fibro, bulging discs and other pain. I am also in the need for a muscle relaxant and had read that Soma/carisoprodol is a good one and was also going to request that. Further I have been having severe anxiety for all of this pain trouble sleeping and other things going on in my life right now. I was going to ask for Valium (Diazepam) too but didn't know enough about meds to know what class they are in, types they are, and if all would be filled for me. Could someone with knowledge in this subject let me know before I make a complete fool of myself. I also hope I am able to get all of these or feel I may loose my mind from the pain I deal with everyday. I am also going to see someone and hopefully that will also help.
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#81145 - 09/30/05 09:49 PM
Re: Lorezapam
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