Speaking straight to depression and the possible "side effect" of suicide: Chantix and related drugs

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#687813 - 04/23/08 07:34 PM Speaking straight to depression and the possible "side effect" of suicide: Chantix and related drugs
stits stits Banned. Making other posters not want to visit... GRAND Pooh-Bah Registered: 10/15/05 Posts: 2981 Loc: Stitsville, Virginia	You guys are ahead of teh news. $\:\)$ On my Homepage today i find Suicide risk dims hope for anti-addiction pills Once-promising treatments tied to psychiatric problems in patients The Associated Press CHICAGO - Two years ago, scientists had high hopes for new pills that would help people quit smoking, lose weight and maybe kick other tough addictions like alcohol cocaine, and chronic DB.com use. The pills worked in a novel way, by blocking pleasure centers in the brain that provide the feel-good response from smoking or eating. Now it seems the drugs may block pleasure too well, possibly raising the risk of depression and suicide. Stop teh tape! stop teh tape! I always did look sideways when I saw "anti-addiction" pharmaceutical-development with a design-approach geared toward blocking or otherwise interfering with 1) endorphins, or which might 2) play around with the major neurotransmitters like dopamine. While the principle is impossible to predict, researchers are wise at least not to forget the law of unintended consequences. "Of course you're going to feel like killing your fcking self if a drug approach backfires and depletes those same neurochemicals (and the brain is very little understood, remember) which are intimately involved with the sense of wellbeing," I would muse. Margaret Bastian of suburban Rochester, N.Y., was among patients who reported problems with Chantix, a highly touted quit-smoking pill from Pfizer Inc. that has been linked to dozens of reports of suicides and hundreds of suicidal behaviors. "I started to get severely depressed and just going down into that hole .... the one you can't crawl out of," said Bastian, whose doctor took her off Chantix after she swallowed too many sleeping pills and other medicines one night. Side effects also plague two other drugs: -Rimonabant, an obesity pill sold as Acomplia in Europe, was tied to higher rates of depression and a suicide in a study last month. The maker, Sanofi-Aventis SA, still hopes to win its approval in the United States. -Taranabant, a similar pill in late-stage testing, led to higher rates of depression and other side effects in a study last month. Its maker, Merck & Co., stopped testing it at middle and high doses. The makers of the new drugs insist they are safe, although perhaps not for everyone, such as people with a history of depression. Having to restrict the drugs' use would be a big setback because it would deprive the very people who need help the most, since addictions and depression often go hand-in-hand, doctors say. Well I mean DUH. I kinda foresaw this before even embarking on the article. A bigger fear is that the whole approach may be in trouble. Researchers say blocking pleasure, especially the way the obesity drugs do, might take the fun out of many things, not just the harmful substances and behaviors these drugs target. Read the full article here, which concludes predictably with Psychiatrist Dr. Jesse Wright at the University of Louisville, said Chantix helped one of his schizophrenic patients, "who smoked like a smokestack," without worsening his psychological symptoms. and a Dr. Geoffrey Williams, "co-director of the Greater Rochester Area Tobacco Cessation Center"--and a paid speaker for Pfizer "The risk-benefit ratio is still very much on the side of use of the medication." "The alternative, smoking, is extremely highly risky." Copyright 2008 The Associated Press. All rights reversed. This material damned well better not be rewritten or otherwise molested by some pillhead.* UH, oh. Brought to you (entertainment and all) by teh venerable master of creative syntax manipulation: Stits, here showing off some formidable expressive dexterity and perspicacious prowess. (Writing students: Look for my use of combined assonance & alliteration.) Stits _________________________ "Ignore." It's like my own little mini-ban. $\:\)$
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#687815 - 04/23/08 07:42 PM Re: Speaking straight to depression and the possible "side effect" of suicide: Chantix and related drugs [Re: stits]
1219wendy 1219wendy GRAND Pooh-Bah Registered: 06/28/07 Posts: 2138 Loc: IN GOD'S HEART!	Well, my hubby and myself were 2 that became severly depressed. I went off of it first because I was hearing voices. My hubby continued and had multiple side effects including depression. He went off and it took him a good 2 weeks to get back to a somewhat normal life. I tell people considering this drug to don't do this. It is more harmful than it is helpful. Good article stits! _________________________ Don't Work Hard.... Work Smart!
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#687850 - 04/23/08 09:09 PM Re: Speaking straight to depression and the possible "side effect" of suicide: Chantix and related drugs [Re: stits]
neofate neofate GRAND Pooh-Bah Registered: 10/30/02 Posts: 1713 Loc: Southern, US	Originally Posted By: stits and a Dr. Geoffrey Williams, "co-director of the Greater Rochester Area Tobacco Cessation Center"--and a paid speaker for Pfizer "The risk-benefit ratio is still very much on the side of use of the medication." "The alternative, smoking, is extremely highly risky." Stits This last statement had me sadistically amused $;\)$ Die next month, or in a few decades? sigh.. The bright side of all of this, to me, is yes its all linked together, yes we don't know what the hell we are doing... but, we threw a bunch of molecules together and it got a predictable response out of a common mean group of people. Now, how can we use this HUGE study we just undertook at the customers expense (quite literally) and apply it to mental health pharmaceutical research? Seriously, I think this could be a big clue/jumpstart to the beginning of some breakthroughs with all of our constant mumbo jumbo of the Amygdala/Hippocampus -(pleasure/reward center) science jargon out there. Start deducing, experimenting and generally doing what those crazy but genius neuroscientists like to do and we might be on to something sooner than later. $\:\)$ -- No, not the Chantix and its protoge's but the whole ideology behind what is occuring. Nonetheless, excellent stuff as always Stits. Is it just me, or have you taken on a stronger interest in your non-verbal communication talents since I last visited? _________________________ -/\/eofate "Efforts and courage are not enough, without purpose and direction."
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#687870 - 04/23/08 10:13 PM Re: Speaking straight to depression and the possible "side e [Re: neofate]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	Can some master of creative syntax manipulation explain what "teh" is supposed to mean?
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#687873 - 04/23/08 10:31 PM Re: Speaking straight to depression and the possible "side e [Re: nephro]
Kaiboshman Kaiboshman Old Hand Registered: 03/12/08 Posts: 415	I think it's a word scramble. $;\)$ _________________________ "Most people's so-called reasoning consists of finding reasons to go on thinking exactly as they already do." - Colin Wilson
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#687888 - 04/24/08 12:11 AM Re: Speaking straight to depression and the possible "side e [Re: nephro]
neofate neofate GRAND Pooh-Bah Registered: 10/30/02 Posts: 1713 Loc: Southern, US	Originally Posted By: nephro Can some master of creative syntax manipulation explain what "teh" is supposed to mean? Surely you are joking? If for some reason not,.. http://en.wikipedia.org/wiki/Teh $\:\)$ _________________________ -/\/eofate "Efforts and courage are not enough, without purpose and direction."
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#687897 - 04/24/08 12:56 AM Re: Speaking straight to depression and the possible "side e [Re: neofate]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	So it's a sarcastic, Chinese/English accidental-on-purpose misspelling of 'the', used by gamers to mean 'the best', but at the same time 'lame', performed by, for example, John, but it was really Phil, when he was going to say 'pwn' after it, but didn't, because he was unscrambling the word. Well that clears that up. As it says at the top of the Wiki article, "This article or section has multiple issues." Maybe it stands for something, like 'lol'? Tchah, Er... Hell!
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#687900 - 04/24/08 01:04 AM Re: Speaking straight to depression and the possible "side e [Re: nephro]
neofate neofate GRAND Pooh-Bah Registered: 10/30/02 Posts: 1713 Loc: Southern, US	No, it is code for,.. all your base belong to us. I think most acronyms are at best, people being LAZY. Though there are some common by all 'walks of life and ages' that I don't find somewhat annoying. Teh is not one of them. I've never understand what was/is so 'cool' .. or perhaps dorky/nerdy (thats cool to some people) about mispelling a word on purpose. Technically teh isn't an acronym,.. its slang.. Again, I'm tired heh.. but you know what I mean. Now for real, were you really at a loss? Or are you now continuing to be insiduously dumbfounded? $\:\)$ _________________________ -/\/eofate "Efforts and courage are not enough, without purpose and direction."
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#687901 - 04/24/08 01:20 AM Re: Speaking straight to depression and the possible "side e [Re: neofate]
scruf scruf GRAND Pooh-Bah Registered: 03/21/05 Posts: 2565 Loc: pacific nw	I always thought it was just a typo of "the" for those who don't care how 'duh' they appear.
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#687904 - 04/24/08 01:55 AM Re: Speaking straight to depression and the possible "side e [Re: scruf]
stits stits Banned. Making other posters not want to visit... GRAND Pooh-Bah Registered: 10/15/05 Posts: 2981 Loc: Stitsville, Virginia	Well the etymology is really tri-fold. Having evolved into a veritable neologism by now, the intentional misspelling of "the" belongs to the province of the younger generation. In other words, if you have to ask, it's a dead give away that you're not a gamer. lol Also (#2), scruf is correct. And finally... you know. It's teh "in" thing. Same reason many ppl will intentionally use lower-case for the proper first-person, "I." hth, Stits _________________________ "Ignore." It's like my own little mini-ban. $\:\)$
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#687908 - 04/24/08 02:15 AM Re: Speaking straight to depression and the possible "side e [Re: stits]
scruf scruf GRAND Pooh-Bah Registered: 03/21/05 Posts: 2565 Loc: pacific nw	yep, I am not a gamer. just an oldie who learns new stuff every day! I am going to have to get out my dictionary if these posts continue. etymology?? is that a new word, or just new to me? and altruism is a word I've heard all my life, but never knew what it meant. pi$$es me off that there are any words left I don't know the meaning of at my age! do't give a sh1t like I used to though.
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#687956 - 04/24/08 06:31 AM Re: Speaking straight to depression and the possible "side e [Re: scruf]
jl767 jl767 Threadhead Registered: 08/12/05 Posts: 836 Loc: Gotham	What are you all so damn old that you don't remember the dumb $hit you guys did as youngsters. The "kids these days" are the same ignorant kids we were. The only difference is the "world around them moves a little faster". Well, not really, information just moves in greater quantities and faster. I get depression (a little funky) from some antibiotics. Certain medication after a week or so starts to mess with my head. I am not sure why that is, but it may be my relationship with medication (preconceived notions). I buy/pick-up pills take them for a week or two and flush them. It happens to me all the time. I know stopping medication early is a no no, but I have been lucky so far. I guess this is a bit different than full-blown depression, but I get really self reflective on certain medication. "I'm A Freak"
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#688064 - 04/24/08 09:32 AM Re: Speaking straight to depression and the possible "side e [Re: neofate]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	Probably more insidiously, but bear in mind that there was recently a spyware program (SpySheriff - a particularly nasty one) which would download from the Merriam-Webster site, so be careful of using that to check the meanings or spellings of such words. Seriously, the last game I played was Boulderdash on my Amstrad CPC464 from 1986, and I sold it because I was playing it too much. I've seen 'teh' many times but always assumed it to be an accidental typing error, but maybe half the time it wasn't. Depression and computer games. Any relationship?
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#688240 - 04/24/08 02:10 PM Re: Speaking straight to depression and the possible "side e [Re: nephro]
stits stits Banned. Making other posters not want to visit... GRAND Pooh-Bah Registered: 10/15/05 Posts: 2981 Loc: Stitsville, Virginia	^ lol@JL, made me laugh Originally Posted By: nephro Probably more insidiously... "more conspiracy-think or alarmist might be closer to what you're trying to express? Originally Posted By: nephro Seriously, the last game I played was Boulderdash on my Amstrad CPC464 from 1986, and I sold it because I was playing it too much. Mehh, idk. I'm calling balderdash. j/k Originally Posted By: scruf yep, I am not a gamer. just an oldie who learns new stuff every day! I am going to have to get out my dictionary if these posts continue. etymology?? is that a new word, or just new to me? and altruism is a word I've heard all my life, but never knew what it meant. pi$$es me off that there are any words left I don't know the meaning of at my age! do't give a sh1t like I used to though. lol... No, you are enough just as you are Scruffie-doodles. (((sruf))) I was tickled by your profile, saying you found DB.com from being freaked over the whole anthrax/post-9/11 scare. lol -I honestly cannot remember how I found this place, which was almost surely by accident and is why you see... "Dubious serendipity" in my Profile. lol Hey Scruf, when you're game for another brain-drain (watch Nephro jump all over this: "Wait! Wait! i know some philosophy! i, i know philosophy!" grr-hiss lol) try out Philology recapitulates ontology. The assertion is a kind of lazy a priori dig at the recursive outcomes of the respective disciplines you encounter in philosophy. I wrote an easier to understand interpretation (or "answer") below. Philology is the study of speech and literature (linguistics). Ontology is [ont- meaning being or existence + -ology, the study of]. The recapitulation descriptor simply indicts both as being one and the same for any practical purposes. Originally Posted By: nephro Depression and computer games. Any relationship? Oh you damned well bet: U.S.$63 for a single flippin' game. lol $400 game consoles that overheat and die (we're staring straight at you, Microsoft, Xbox 360; failures rates establsished at 16%-20%). Causal relationship or exasperation of depression? Uhh. Yep. Stits _________________________ "Ignore." It's like my own little mini-ban. $\:\)$
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#688264 - 04/24/08 02:45 PM Re: Speaking straight to depression and the possible "side e [Re: jl767]
stits stits Banned. Making other posters not want to visit... GRAND Pooh-Bah Registered: 10/15/05 Posts: 2981 Loc: Stitsville, Virginia	Originally Posted By: jl767 What are you all so damn old that you don't.... LOL... was just reviewing the thread and that what got me--"why sugarcoat?" lol! JL: uhh-yep, prolly that's pretty close. Prolly. Originally Posted By: jl767 "I'm A Freak" Body and soul? Little Silverchair, ne1? $;\)$ _________________________ "Ignore." It's like my own little mini-ban. $\:\)$
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#688271 - 04/24/08 02:56 PM Re: Speaking straight to depression and the possible "side e [Re: stits]
jl767 jl767 Threadhead Registered: 08/12/05 Posts: 836 Loc: Gotham	Hey I apologize to everyone. I am an old Geezer. I was just kidding around. I actually remember playing "Leisure Suit Larry" on an Apple IIe (with floppy disks). I even had a Studio II game console in the 70s. Edited by jl767 (04/24/08 03:00 PM)
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#688275 - 04/24/08 03:00 PM Re: Speaking straight to depression and the possible "side e [Re: stits]
neofate neofate GRAND Pooh-Bah Registered: 10/30/02 Posts: 1713 Loc: Southern, US	I like where this thread has totally slipped off the track.. rolled over and is now steadily tumbling down the ravine of reckoning. $;\)$ Anyhow back to the offtopic topic,.. Neph, the whole 'teh' ordeal isn't specific to the US.. Those crazy kids in the UK are doing it to! $\:\)$ I am an avid gamer, over my illustrious career of FPS shooter on dial-up modems to MMORPG's and back to a little something I like to dabble with called ET:QW. I haven't hit 30 yet so I'm not quite a 'fogey' but I think gaming for a certain generation and 'up' (or down if you prefer), is here to remain. Yes, I anticipate 45, 55yr old men reliving their youth through an array of virtual bullets or 1's and 0's pummeling their comrad 3000 miles away. As for depression and Chantix.. uh, yeah I think we've nailed that one.. Depression and gaming. Sure, any isolating experience will 'exasperate' it as Stits refers but I think those games in which you actually 'speak' to the others instead of type lessens the depressive effect a 'touch'. Casual gaming, though, I can't see having any long lasting disorderly mental properties $\:\)$ _________________________ -/\/eofate "Efforts and courage are not enough, without purpose and direction."
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#688281 - 04/24/08 03:06 PM Re: Speaking straight to depression and the possible "side e [Re: neofate]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	Originally Posted By: neofate Neph, the whole 'teh' ordeal isn't specific to the US.. Those crazy kids in the UK are doing it to! $\:\)$ If I see any, and I'll give them the necessary slap. I don't mind them writing notes to each other in lessons, but any text message lingo and they'll lose their dinner.
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#688282 - 04/24/08 03:08 PM Re: Speaking straight to depression and the possible "side e [Re: neofate]
NotBillGates NotBillGates GRAND Pooh-Bah Registered: 01/15/04 Posts: 2535 Loc: 867-5309	Well, I have my Playstation II and really enjoy playing Buzz the Mega Quiz with my friends and neighbors. It is developed by Sony of UK. Makes me think of *Nephro* when I play. "It features: Point Picker, Winner Stays On and The Final Countdown, Buzz has also worked with producers to develop "Mystery Games" - special rounds where he takes to centre stage and challenges the contestants to take him on. These special rounds give Buzz the opportunity to show off his multi-talented nature as a card shark, horse trainer and all-round raconteur." _________________________ “Choosing Obama is a great opportunity for Americans to show the world they can change, be humble and learn from their mistakes." - Nelson Mandela
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#688286 - 04/24/08 03:13 PM Re: Speaking straight to depression and the possible "side e [Re: NotBillGates]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	Sony of UK? It'll break down before long.
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#688311 - 04/24/08 03:40 PM Re: Speaking straight to depression and the possible "side e [Re: nephro]
stits stits Banned. Making other posters not want to visit... GRAND Pooh-Bah Registered: 10/15/05 Posts: 2981 Loc: Stitsville, Virginia	XDuke 360 is where's it's all at baby. i can't get enough PGR4. Driving games are all I play. _________________________ "Ignore." It's like my own little mini-ban. $\:\)$
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#688324 - 04/24/08 04:01 PM Re: Speaking straight to depression and the possible "side e [Re: stits]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	I think I drove behind you on the way to work yesterday.
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#688331 - 04/24/08 04:19 PM Re: Speaking straight to depression and the possible "side e [Re: nephro]
funkybreakz funkybreakz Pooh-Bah Registered: 01/24/04 Posts: 1114 Loc: My Living Room	Originally Posted By: nephro Seriously, the last game I played was Boulderdash my wife and i have this board game! we love it! and no... i am not an old fogie... although i thought it was balderdash. could it be a different game? _________________________ cat on a tin roof, dogs in a pile, nothin left to do but smile smile smile!
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#688536 - 04/25/08 05:01 AM Re: Speaking straight to depression and the possible "side e [Re: funkybreakz]
nephro nephro GRAND Pooh-Bah Registered: 09/04/06 Posts: 8574 Loc: UK, despite the rumours	It wasn't a board game on the computer, and involved a character called Rockford I think, trying to obtain jewels without rocks falling on his head. Highly addictive!
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#688620 - 04/25/08 07:49 AM Re: Speaking straight to depression and the possible "side e [Re: nephro]
stits stits Banned. Making other posters not want to visit... GRAND Pooh-Bah Registered: 10/15/05 Posts: 2981 Loc: Stitsville, Virginia	Originally Posted By: nephro It wasn't a board game on the computer That would be a novelty, board-game on a computer.
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#688709 - 04/25/08 10:09 AM Re: Speaking straight to depression and the possible "side e [Re: stits]
jl767 jl767 Threadhead Registered: 08/12/05 Posts: 836 Loc: Gotham	I still remember the code for "Mike Tyson's Punch Out" 007-373-5963. I saw a "King Hippo" t-shirt the other day. For "Contra" it was up, up, down, down, left, right, left, right, B, A, start. I remember that krap and I forgot my sister's birthday this year. I called her a day late. Edited by jl767 (04/25/08 10:11 AM)
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