 |
 |
 |
 |
#659508 - 02/29/08 11:35 AM
Something in POT might ease pain for those with FM
|
mmyp
GRAND Pooh-Bah
Registered: 02/20/06
Posts: 1702
|
Preliminary Study Shows Less Pain, Better Quality of Life in Fibromyalgia Patients Taking Nabilone
By Miranda Hitti
WebMD Medical News
Reviewed By Brunilda Nazario, MD
Feb. 19, 2008 -- Nabilone, a pain drug based on marijuana's active ingredient, may ease fibromyalgia pain.
So say Canadian researchers, based on a preliminary, short-term study.
The study included 40 fibromyalgia patients. First, they did three things:
Rate the intensity of their fibromyalgia pain. The rating scale ranged from 0 (no pain) to 10 (the worst pain imaginable). Their average rating was about 6.
Rate their quality of life. The rating scale ranged from 0 to 100, with higher scores indicating worse quality of life. Their average rating was 66.
Get a check of their tender points -- parts of the body that are often sensitive in fibromyalgia patients.
The researchers then split the patients into two groups.
For a month, one group of patients took nabilone daily. The other group took a placebo pill. The patients didn't know which pill they were taking.
After a month of nabilone treatment, fibromyalgia pain was less intense and quality of life had improved. No such changes were seen with the placebo.
Nabilone treatment didn't affect the patients' number of tender points. And it didn't cure fibromyalgia pain -- when patients stopped taking nabilone, their fibromyalgia pain returned to its former intensity.
Nabilone was well tolerated, but side effects were more commonly reported in the nabilone group. Those side effects -- which included drowsiness, dry mouth, vertigo, and movement problems -- were "generally mild," write the researchers.
Longer studies are needed to track the long-term effects, note the University of Manitoba's Ryan Quinlan Skrabek, MD, and colleagues.
Their study appears in the February edition of The Journal of Pain.
SOURCES: Skrabek, R. The Journal of Pain, February 2008; vol 9: pp 164-173.
_________________________
Your village called... they want their idiot back !
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
|
|
|
|
|
#659513 - 02/29/08 11:37 AM
Re: Something in POT might ease pain for those with FM
[Re: mmyp]
|
MARLEY
GRAND Pooh-Bah
Registered: 10/14/05
Posts: 4061
Loc: Vote Obama!
|
Medical Marijuana serves multiple medical purposes that have been PROVEN. Nice thread! This country needs to wake up on the topic of medical marijuana.
-MARLEY
|
|
Top
|
|
|
|
|
|
|
|
|
|
|
|
|
|
#659723 - 02/29/08 03:36 PM
Re: Something in POT might ease pain for those with FM
[Re: nephro]
|
mmyp
GRAND Pooh-Bah
Registered: 02/20/06
Posts: 1702
|
Thought this might help the discussion:
Nabilone
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Nabilone
Systematic (IUPAC) name
(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-
-7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one
Identifiers
CAS number 51022-71-0
ATC code A04AD11
PubChem 5284592
DrugBank APRD01127
Chemical data
Formula C24H36O3
Mol. mass 372.541 g/mol
Pharmacokinetic data
Bioavailability 20% after first-pass by the liver
Protein binding similar to THC (+/-97%)
Metabolism ?
Half life 2 hours, with metabolites around 35 hours.
Excretion ?
Therapeutic considerations
Pregnancy cat. NA
Legal status Schedule II(US)
Routes Oral form (PO)- capsule
Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It is a synthetic cannabinoid, which mimics the main ingredient of marijuana (THC) but it has more predictable side effects and causes no or minimal euphoria. Nabilone is not derived from the cannabis plant as is dronabinol.
In Canada, the United States, the United Kingdom and Mexico, nabilone is marketed as Cesamet. It was approved in 1985 by the United States FDA for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. Though it was approved by the FDA in 1985, the drug only began marketing in the United States in 2006. It is also approved for use in treatment of anorexia and weight loss in patients with AIDS.
Although it doesn't have the official indication (except in Mexico), nabilone is widely used as an adjunct therapy for chronic pain management. Numerous trials and case studies have demonstrated various benefits for condition such as fibromyalgia and multiple sclerosis[citation needed].
Nabilone is a racemic mixture consisting of the (S,S) and the (R,R) isomers ("trans").
[edit] Clinical trials
The main settings that have seen published clinical trials of nabilone include movement disorders such as Parkinson's syndrome, chronic pain, dystonia and spasticity neurological disorders, fibromyalgia, multiple sclerosis, and the nausea of cancer chemotherapy.
A study comparing nabilone with metoclopramide, conducted before the development of modern 5-HT3 inhibitor anti-emetics such as ondansetron, revealed that patients taking cisplatin chemotherapy preferred metoclopramide, while patients taking carboplatin chemotherapy preferred nabilone to control nausea and vomiting. [1] Another study compared nabilone alone to nabilone with dexamethasone. The study found that the combination worked better than the single medication. [2] An older study revealed that nabilone was more effective than prochlorperazine in controlling nausea, though in this study, only 9% of nabilone patients had complete resolution of symptoms. [3] A follow-up to this study revealed similar findings. [4]
One study compared the efficacy and tolerability of nabilone with that of dihydrocodeine in the treatment of neuropathic pain.[5] The authors found that nabilone was not as effective as dihydrocodeine in controlling pain, and caused a higher incidence of minor adverse drug reactions than did dihydrocodeine. One critic of the study has suggested that nabilone might be best suited for the treatment of patients suffering from central and spasticity-related pain, for which there is stronger evidence for the benefits of cannabinoid therapy; however, these patients made up only a small fraction of the study's population, and the study was not designed to identify subgroups which might have responded more favorably to treatment than others.[6]
[edit] References
_________________________
Your village called... they want their idiot back !
|
|
Top
|
|
|
|
|
|
|
|
|
| |
