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#626368 - 01/07/08 04:21 PM SSRIs for depression
geministars Offline
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I know that people sometimes have to try different medications until they find the one that works well for them. My question is, what are the chances that a person would respond to one SSRI (paxil) when another (zoloft) had been already been tried unsuccessfully? Also, if the paxil isn't working at all, would increasing the dosage from 20mg to 30mg be apt to make a difference?
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#626394 - 01/07/08 05:08 PM Re: SSRIs for depression [Re: geministars]
mozartkc Offline
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Registered: 10/24/05
Posts: 258
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Hi Gemini,
I honestly don't know what to tell ya:) I have been on both Paxil and Zoloft after my mothers death. It is a huge rollercoaster ride with these meds. Yes, they made me feel better after a few weeks. Yes, they were HORRIBLE to come off of. I can honestly say that I myself felt better OFF these. Everyone's body chemistry is different though. After several visits to a shrink I found that my depression was getting worse with these meds. I hope you have a wonderful week and find which chemical your brain needs. I know how hard it is. Just Pray:)
S

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#626400 - 01/07/08 05:15 PM Re: SSRIs for depression [Re: geministars]
dmg Offline
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Registered: 10/27/03
Posts: 2700
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Unless you put your foot down, which you may NOT want to do, you probably should get used to the merry-go-round of Anti-Depressant meds- because that's how they're tried - just hit and miss and hope you are given the one that works first. IF there is one that's going to work period. It's a big crapshoot.

I would keep in mind though that they're not ALL the same, regardless of how some may feel. Technically I think some operate differently or are chemically different than others, and thus, should have some sort of chance of possibly working.

Just try not to get down on yourself, down on your luck. Sure, maybe AD's aren't going to work, but who knows. Just don't count yourself out before the verdict is in, that's all.
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#626422 - 01/07/08 05:46 PM Re: SSRIs for depression [Re: dmg]
geministars Offline
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Thanks guys, I appreciate your input. It isn't me though, not that I haven't had my own struggles with depression in the past. I was just lucky enough to be prescribed something that worked right off the bat. It is, however, a teenage relative of mine. The thing that makes it so hard with it being a teenager is trying to keep her from getting discouraged. She was very hopeful when she first went to the psychiatrist in Aug. Now, five months later, she is beginning to feel hopeless because she isn't any better. It's difficult to keep telling her to just hold on, that it will get better because I really think she believed it at first but is starting to think it won't get any better because it hasn't yet.
Thanks again though, and I would really appreciate hearing others' opinions too.
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#626451 - 01/07/08 06:28 PM Re: SSRIs for depression [Re: geministars]
greyman Offline
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Geministars, one could argue that the teen might be too young to prescribe any ssri (I am guessing paxil).

Paxil is awful. I have never tried zoloft. Celexa works well with me.

Your relative is discouraged. Likely about a lotta stuff. When I was that age (16,17,18) I hated myself, was as neurotic as a kid can be, fearful, full of despair, alienated from my "peer group," unable to make friends, I felt totally weird, scared, and generally stupid.

Now throw a psychotropic into the mix, and , well, don't be surprised at the reaction from a young mind.

Just a thought. I am 46, and NO WAY could I live those teen years again!!!
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#626460 - 01/07/08 06:46 PM Re: SSRIs for depression [Re: greyman]
geministars Offline
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You're so right, the teen years are hard. This is a girl who has everything going for her- extremely intelligent, beautiful, popular- and miserable, because none of those other things matter when your depressed. One well meaning person who obviously didn't understand depression even said, "Why would she be depressed? She's so pretty and smart." To me, that's like saying, "Why do you have diabetes? You have so many reasons to be healthy and happy." No one chooses to be depressed any more than anyone chooses to have any disease, and many people don't realize that depression is often not the result of something being "wrong". It sometimes just IS, for no apparent reason. I just wish I knew what to do to help.
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#626535 - 01/07/08 08:46 PM Re: SSRIs for depression [Re: geministars]
geministars Offline
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So if anyone has any other suggestions... I really would appreciate it. How do you convince them that it will get better even though they've already been told that but it hasn't yet? What can a person do to convince them when they feel so miserable and hopeless?
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#626656 - 01/07/08 11:53 PM Re: SSRIs for depression [Re: geministars]
thundr69 Offline
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The thing that I've said to my daughters is this. "It is very easy to feel hopeless at this age. I felt that way too. You're becoming an adult now, thinking about things in a different way and unfortunately, finding out that life is often hard and you often feel like [censored]. I felt this exact same way. Very often you feel like things will not get better. I felt this way too. I know that you don't feel it right now and I know that you probably can't see it but the one thing I can tell you that I have learned and that ONLY comes from age and experience is this, bad times do pass. They will also come again. Sometimes we have bad days, you will find out that you will also sometimes have, bad weeks, bad months and even a bad year but, that always passes. It DOES get better and you WILL have good times again and even long stretches of good times. I lived through this and I know it for a FACT. Things will get better and the hugest problem I had at your age was believing that. But, it is the one thing that I do know for sure, bad times ALWAYS pass, we just MUST ride it out."
I have said this to my girls, one 20 one 24, very frequently last year because it was one of their most difficult years and certainly one of the worst I've had. They are miserable right now but holding on. Tell your relative, honestly, about some of the REALLY tough things you've gone through. Then, point out when that cloud lifted. Tell her, it never ever rains forever. Tell her to look up into the sky and know this one thing, the sun will come out eventually. Good luck to you and her. You're in my prayers.
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#626666 - 01/08/08 01:20 AM Re: SSRIs for depression [Re: thundr69]
nannyann Offline
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Registered: 09/14/04
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My grandsons have both been taking depression meds since they were about 3 and 5. They are 10 and 12 now and both take Lexapro. I had a horrible time finding a depression med that I could take. I take Lexapro and have had no problems with it
nanny

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#626737 - 01/08/08 07:08 AM Re: SSRIs for depression [Re: nannyann]
geministars Offline
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thundr and nannyann, thank you both so much for your words of wisdom. Lexepro might be something to consider for her. And thundr you're right, she just needs encouragement that it will eventually get better. I think it's especially hard the first time with a bout of depression because you haven't made it through it yet, where as adults we know because we have made it through.
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#627061 - 01/08/08 03:50 PM Re: SSRIs for depression [Re: geministars]
thundr69 Offline
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Gemini, no problem. I truly believe that knowing that these things do pass is something I've only come to know because of what I've lived through. I feel so sorry for young people because they are just starting out and haven't gotten over a lot of their problems yet, for most of them, it's just getting started---bleak looking indeed. They are just experiencing these things for the first time and it comes as a shock. They're just leaving childhood behind and BAM, all the trials of an adult life hit them. I hope and pray all goes well for her and you and also wanted to say, I love Rita Mae Brown!
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The only courage that matters is the kind that gets you from one moment to the next.
Mignon McLaughlin


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#634121 - 01/19/08 06:01 PM Re: SSRIs for depression [Re: geministars]
stressedout Offline
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I am not sure what to say. I have tried both and neither helped. I am now on Wellbutrin (which isn't an SSRI) and all I can say is it's a great drug, with the side effect of weight loss and increased engery. A great side effect for me I might add.
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#634172 - 01/19/08 10:13 PM Re: SSRIs for depression [Re: stressedout]
scruf Offline
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If wellbutrin is not an ssri, what is it?
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#634209 - 01/20/08 01:37 AM Re: SSRIs for depression [Re: scruf]
DonVito Offline

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Registered: 02/18/07
Posts: 183
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C and P from drug list. They say it best:

WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
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#634251 - 01/20/08 07:55 AM Re: SSRIs for depression [Re: DonVito]
geministars Offline
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Stressedout and DonVito, thanks for the info. I thought wellbutrin was also an ssri. Do you know what other antidepressants are in the same class and how they work?
Her next appt. is next week. Since two ssri's have been tried unsuccessfully, is it a safe assumption that no ssri will work and another class of antidepressants should be tried now?
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#636170 - 01/22/08 11:36 PM Re: SSRIs for depression [Re: geministars]
Stargirl Offline
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Registered: 01/08/08
Posts: 45
This is interesting. I suffer from depression and anxiety. I hated Zoloft, because it made me more depressed. My daughter called a couple of days ago and I could not even talk to her. Some of these new anti-depressants sound pretty good and well worth looking into!
Thanks for bringing this up.
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#636174 - 01/23/08 12:55 AM Re: SSRIs for depression [Re: geministars]
fashana Offline
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Registered: 02/21/07
Posts: 251
Loc: Washington
 Originally Posted By: geministars
I know that people sometimes have to try different medications until they find the one that works well for them. My question is, what are the chances that a person would respond to one SSRI (paxil) when another (zoloft) had been already been tried unsuccessfully? Also, if the paxil isn't working at all, would increasing the dosage from 20mg to 30mg be apt to make a difference?


I am sorry but no.

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#636764 - 01/23/08 11:04 PM Re: SSRIs for depression [Re: fashana]
DonVito Offline

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Registered: 02/18/07
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First of all, increasing the dosage of a SSRI, such as Zoloft, may be effective. There is really no way to find out unless you try. There becomes a point where one certainly cannot increase the dosage any further, and must taper off and try something new, add another medication, lifestyle modifications, and talk therapy.

One must be vigilant when managing these drugs because of the side-effects when discontinuing them.

Depending on her symptoms, one could recommend other meds. It certainly takes time. There is no silver bullet. The task of actually figuring out where the depression is stemming from can provide relief and a certain freedom. Of course, chemical insufficiencies can be to blame, but life changes, boredom, anxiety and other issues may be at play.

I would suggest anyone who suffers with depression to keep a diary and look back on it as they go. What made those bad days so bad? How could it have been better? What made the good days good? How can you continue to incorporate the things that made you happy into your life on a regular basis?

A pill will not do all the work, but it can assist you with getting the work done.

Again, if she is not having success with SSRI therapy, please take her to a psychologist who have much more experience with those medications and have contacts to help you face the battle.
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#636776 - 01/23/08 11:47 PM Re: SSRIs for depression [Re: DonVito]
recruiterlo Offline

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i have been hoping this subject would come up. first let me say that i am sorry for geminstars young relative and wish i had an answer. other than going to a good shrink and to be there for her emotionally i don't.

but i would like to find out from anyone about lexipro as i just started this week and only had the samples from my dr.i am filling the script tomorrow but it seems to work well right off the bat -- however, i would love to hear from anyone who has any experience taking it for a time.

i have not taken ads for a couple of years and am not able to handle prozak, and zoloft was tolerable for a while but i stopped and felt better with zip.

but now zip doesn't work so i researched meds on the web and it was a crapshoot -- which i won. i am curious as to why this one works. anyone?

thanks.
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#636991 - 01/24/08 10:54 AM Re: SSRIs for depression [Re: recruiterlo]
Alyssa03 Offline
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Registered: 03/10/05
Posts: 640
Not to hijack anyone's thread, but I was wondering the same thing about Cymbalta. Anyone have any success with it?

Thanks,
Alyssa

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#637302 - 01/24/08 06:46 PM Re: SSRIs for depression [Re: Alyssa03]
recruiterlo Offline

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wish i could tell you as no-one has answered. what i've read about it was only that it can make one tired -- but i've seen that said about many medications.

does it help you and when did you start taking it? it was one i was considering so just would like to hear something.

thanks.
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#637522 - 01/25/08 09:30 AM Re: SSRIs for depression [Re: recruiterlo]
Alyssa03 Offline
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Registered: 03/10/05
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Thanks for responding, I always feel like such a loser when absolutely noone says anything (it happens a lot!)

I started taking it several weeks ago because my Dr. felt it would help with some of my pain issues. Apparently it is one of the SSRIs marketed towards chronic pain sufferers. It's weird, I really don't feel that different than before I started taking it. I didn't think I would be dancing around with butterflies swarming the room, but I did think I would feel more of a significant difference.

My husband and family seem to think I am doing better...maybe it is one of those subtle things that only others can really tell if it's helping, i don't know. My depression was a result of a bad accident and the repercussions that I am now dealing with. It was never "severe," just a mild case.

I really hope some others will chime in, it'd be nice to get some more feedback.

Thanks again, I hate being a "thread-killer."

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#637531 - 01/25/08 09:45 AM Re: SSRIs for depression [Re: Alyssa03]
Rico1 Offline
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Registered: 05/05/07
Posts: 121
Alyssa03~
I too take Cymbalta...120mg. along with Wellbutrin 300mg a day. I haven't noticed any change either. I still have pain, still depressed and getting discouraged! I feel your pain. At least at the end of the Cymbalta commercial that runs on TV, the people are smiling, going out, talking to others and appear happy! I feel like the before pictures all of the time.

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#637538 - 01/25/08 09:52 AM Re: SSRIs for depression [Re: DonVito]
Rico1 Offline
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Registered: 05/05/07
Posts: 121
DonVito~
Sorry to jump off subject here, but I loved your little doggie. I love Chihuahua's too!! Sorry for the interupt. \:\)

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#637663 - 01/25/08 01:18 PM Re: SSRIs for depression [Re: Rico1]
recruiterlo Offline

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Registered: 05/01/06
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there is no truth in advertising. what i do for a living is recruit people from one pharmaceutical advertising agency to another so i'm embarrassed to say that the reason i picked pharma is that people will always need drugs even in recession.

having said that, i can tell you those dtc (consumer) ads are to suck you in and cymbalta is a perfect example. "depression hurts, but you don't have to" -- right! and that is why i decided on lexipro because at least i can use my insight to help myself.

no one knows what really will work, i just know what won't and also i am privvy to what insiders think of these drugs. i at least was able to get my kid off of vioxx before it was too late as the ceo of the agency who represents vioxx was my mentor. i can tell you that any of the drugs that do not have long term studies are suspect by the guys/gals who represent the pharma industry.

buyer beware is a good motto.
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#637889 - 01/25/08 06:40 PM Re: SSRIs for depression [Re: Rico1]
Alyssa03 Offline
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Registered: 03/10/05
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Rico.....I'm only taking 60 mgs. daily. My Dr. said if that doesn't work, he'd rather put me on a new medication as opposed to upping the dosage. He said if 60 mgs. don't work, nothing higher will. Go figure.....every Dr. has their own philosophy I suppose~
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#639269 - 01/28/08 10:39 AM Re: SSRIs for depression [Re: ]
Alyssa03 Offline
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Registered: 03/10/05
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Where?????
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#639271 - 01/28/08 10:40 AM Re: SSRIs for depression [Re: Alyssa03]
Alyssa03 Offline
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