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#954130 - 11/03/09 12:49 AM Tilidine anybody?
painstaking Offline
Old Hand

Registered: 07/21/04
Posts: 413
I recently came across a site claiming to sell this medicine in a form called Tildin containing tilidine hydrochloride. The wiki says that 100mg is equipotent to 20mg morphine. It is vary rare I have ever come across an uknown opiate. And this is a strange one for sure. Not much info on it, and it seems to not follow the general biochemical formula for opiates. It is though highly specific to MU opioid receptors. The pills are offered as 100mg.

Any thoughts, very interesting stuff? Anyone ever heard of it or know anything about it?

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#954171 - 11/03/09 02:52 AM Re: Tilidine anybody? [Re: painstaking]
DeeRock Offline
Threadhead

Registered: 07/11/06
Posts: 856
Loc: St. Louis
something tells me its not all that great. BUT some variations come with naloxone, so that could be promising, it does also say "moderate to severe pain".

it says maximum dose a day is 600mg, anyone know a reason behind this? because if 100mg is equal to 20mg morphine, that makes it equivalent to 120mg of morphine which is a single oral dose of morphine for me.

but see if you can get a small order and try 'em out and let everyone know.
_________________________
All I ever wanted was to pick apart the day,
put the pieces back together my way.

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#954299 - 11/03/09 12:26 PM Re: Tilidine anybody? [Re: DeeRock]
martind Offline
GRAND Pooh-Bah

Registered: 05/01/08
Posts: 2625
Apparently the DEA has some thoughts about tilidine since it has been scheduled as a C-I substance for many years.
You would have to satisfy yourself about the risks involved with importing a C-I drug into the US.
I would guess that the penalties could be much more serious than the warning letters currently being issued for importation of Valium, Tramadol, etc.
The risk/reward question is one only you can really answer.

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#954314 - 11/03/09 12:44 PM Re: Tilidine anybody? [Re: martind]
painstaking Offline
Old Hand

Registered: 07/21/04
Posts: 413
it is specifically scheduled that way, I did not know that. Is that just a regulation that happens with unapproved narcotic meds. Are the benzos that are not FDA apporoved in the US that way also?

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#954388 - 11/03/09 02:48 PM Re: Tilidine anybody? [Re: painstaking]
DeeRock Offline
Threadhead

Registered: 07/11/06
Posts: 856
Loc: St. Louis
Originally Posted By: painstaking
it is specifically scheduled that way, I did not know that. Is that just a regulation that happens with unapproved narcotic meds. Are the benzos that are not FDA apporoved in the US that way also?


I think you're exactly right.
_________________________
All I ever wanted was to pick apart the day,
put the pieces back together my way.

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#954435 - 11/03/09 03:54 PM Re: Tilidine anybody? [Re: painstaking]
martind Offline
GRAND Pooh-Bah

Registered: 05/01/08
Posts: 2625
Originally Posted By: painstaking
it is specifically scheduled that way, I did not know that. Is that just a regulation that happens with unapproved narcotic meds. Are the benzos that are not FDA apporoved in the US that way also?


Doesn't really matter. If the substance is scheduled C-I and is imported by an unlicensed individual into the US, it is a violation of federal law.
As I said before, you have to assess for yourself the criminal risks associated with the difference between illegally importing a substance that is illegal to possess in this country because of its inclusion in the same CSA schedule as heroin, cocaine, MDMA, cannabis and PCP and illegally importing a substance that is legal to possess here but requires a prescription like benzodiazepines or codeine.
The choice seems pretty obvious to me but you may have a different viewpoint.

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#954546 - 11/03/09 06:00 PM Re: Tilidine anybody? [Re: martind]
painstaking Offline
Old Hand

Registered: 07/21/04
Posts: 413
I agree, but I was just commenting then that all those serbian and I think some canadian companies that are offering those unapproved benzos then, I believe they are playing with the same risk.

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#954580 - 11/03/09 06:53 PM Re: Tilidine anybody? [Re: painstaking]
martind Offline
GRAND Pooh-Bah

Registered: 05/01/08
Posts: 2625
Bear in mind, there can be a difference between a substance listed on a C-I schedule and a medication that has not been approved by the FDA for use in the US.
For instance, dichloroacetate (DCA) is an unapproved drug in this country but has never been listed in Schedule I.
The CSA schedules are the responsibility of the DEA whose concern is drugs with abuse potential.
The FDA regulations regarding unapproved medicines are a different animal.
You should check the C-I list to see if any of the "unapproved benzos" are included. I don't recall seeing any benzodiazepines on it but I haven't looked at it in a while.
Also, I believe tilidine has been on that schedule C-I for at least 25 years.

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#954812 - 11/04/09 01:56 AM Re: Tilidine anybody? [Re: martind]
painstaking Offline
Old Hand

Registered: 07/21/04
Posts: 413
Ok I see now, I wonder why then that it is in that scheduling. I mean it is approved in europe and seems like a safe med, why has it never been brought to the US. Its funny because I cannot find any info on it at all except for wiki type stuff posted everywhere which is just a wiki stub

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#955233 - 11/04/09 04:18 PM Re: Tilidine anybody? [Re: painstaking]
martind Offline
GRAND Pooh-Bah

Registered: 05/01/08
Posts: 2625
You would have to ask a historian at the DEA.
Apparently someone convinced the agency back in the eighties that this drug had a high abuse potential without a sufficently accepted level of safety for use by medical practioners in the US.
Similar to the scheduling history involving methaqualone or Paralaudin.
If you research the convoluted background describing how these scheduling decisions are made, you will see that there is an extraordinary amount of subjective, lay medical opinion that ends up influencing the outcomes.

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