 |
 |
 |
 |
#886536 - 05/13/09 10:53 PM
Hydromorphone as breakthrough
|
Threadhead
Registered: 04/20/05
Posts: 811
|
I have been using hydrocodone (norco) as a breakthrough med for years now. Over the past few months, I have noticed that it gives me zero increased relief. Perhaps a tolerance issue, although I have read that sometimes the body just needs a change up. In any case, when discussing this with the doctor I jokingly said that the best break through relief I ever got was while in the hospital (^ times in the past year) with IV hydromorphone. (Dilaudid) He immediately said "I can give you some oral as break through.' so he switched me off of the Norco onto the oral Dilaudid, 2mgs, three times a day as needed.
I'll admit that I do not know the cross tolerance for the two medications, but I have to say that this medication has been a big fat bust. I have not gotten even a scintilla of extra relief from it. Back in the day when the Norco was still working, when I took it for break through it would lower my pain levels within a half hour by a good two or three levels. The dilaudid does NOTHING.
I vaguely recall reading something about the oral bio-availability about oral dilaudid. Does anyone have any knowledge/experience they can share about this medication?
BTW...I did mention to him that the dilaudid was not giving me any relief (at all!) but I am not going to ask for any kind of change in my pain meds for at least a couple of months. I had also asked for an increase in my anti-depressant at the same time and I want to give that a chance to work. My doctor is great about listening to me and is always willing to work with me. I want him to know that I am willing to work with him and give things a chance to work and also that I understand that pain management does not mean the magic removal of all pain at all times. It is kind of sad, but it is a fact of life that we have to be on guard at all times so that we do not appear to be seeking or scamming. If I had a medication that was not controlling my hypertension well, I would have no trouble calling him as often as it took and changing meds as often as it took, to get it under control. Unfortunately, until the medical establishment, the DEA and even the public understand how dangerous intractable pain is, this is the dance we must dance.
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
#886774 - 05/14/09 04:27 PM
Re: Hydromorphone as breakthrough
[Re: nephro]
|
Threadhead
Registered: 04/20/05
Posts: 811
|
For example, for acute pain, 10mg IV morphine = 60mg oral morphine = 1.5mg IV hydromorphone = 7.5mg oral hydromorphone (according to one respected chart). And that's without opioid tolerance. With tolerance, I suggest that your doc is severely under-dosing the drug. That explains a lot. I am a little surprised at my doc. He is usually better at conversions, although I did get the feeling that hydromorphone is not a medication he often uses for break through. It seems to me that since I get such a good result from the LA Oxy that I would do well with some type of IR Oxy? Since I take Prednisone as part of my daily meds, I don't really see any reason for me to go with any of the meds mixed with ASA, Ibuprofren or tylenol. And yes, you are correct Nephro. Increasing my own dosage, while oh so tempting, would be ultimately a very bad idea. Hmmm...."Ah? Doc? I tried taking 4 of those little tabs instead of the one you ordered and it worked much better!" I think his response would be "see ya later, Doodle!" Thanks for the conversions. Now comes the tricky part. Letting my doc in on this little bit of info without sounding as if I am just saying "More! More! More!" Thanks again.
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
#886806 - 05/14/09 05:53 PM
Re: Hydromorphone as breakthrough
[Re: MrsDoodle]
|
GRAND Pooh-Bah
Registered: 10/05/04
Posts: 3800
Loc: In the moment
|
For example, for acute pain, 10mg IV morphine = 60mg oral morphine = 1.5mg IV hydromorphone = 7.5mg oral hydromorphone (according to one respected chart). And that's without opioid tolerance. With tolerance, I suggest that your doc is severely under-dosing the drug. That explains a lot. I am a little surprised at my doc. He is usually better at conversions, although I did get the feeling that hydromorphone is not a medication he often uses for break through. It seems to me that since I get such a good result from the LA Oxy that I would do well with some type of IR Oxy? Since I take Prednisone as part of my daily meds, I don't really see any reason for me to go with any of the meds mixed with ASA, Ibuprofren or tylenol. And yes, you are correct Nephro. Increasing my own dosage, while oh so tempting, would be ultimately a very bad idea. Hmmm...."Ah? Doc? I tried taking 4 of those little tabs instead of the one you ordered and it worked much better!" I think his response would be "see ya later, Doodle!" Thanks for the conversions. Now comes the tricky part. Letting my doc in on this little bit of info without sounding as if I am just saying "More! More! More!" Thanks again. Maybe he's concerned that the hydromorphone won't act as quickly as another product might. As for ibuprofen! They need to put A LOT more warning labels on that! Ibuprofen is contraindicated if you have any type of respiratory difficulty, even allergies. As for your stomach and mixing it with Prednisone--it makes my stomach hurt just thinking about it. I'm down to 20 mg of Prednisone daily. I sure wish it could be less. I don't think that patients are well informed about the side effects--particularly how it affects the mental and emotional status of the client. It's bad enough to have to takeit, but when you start thinking that your normally clear, rational thinking is out of whack because of something you've done, it wallops you with another punch--which we sure don't need! Glad to see you and your melon head baby on the board, Mrs.D!
_________________________
Pay it forward,then let it go. You will be amazed at what comes into your life at just the right time.
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
#889054 - 05/22/09 11:28 PM
Re: Hydromorphone as breakthrough
[Re: MrsDoodle]
|
Newbie
Registered: 09/26/08
Posts: 30
|
2mg of hydromorphone is virtually nothing, and for a tolerant patient?? Its actually laughable.
Its like taking 10mg of morphine, or 5mg of oxycodone... its such a tiny amount it wouldnt even be given to a 12 year old with a sprained ankle... let alone to someone with an opiate tolerance! Seriously, im very sensitive to pharmacologic agents and even without an opiate tolerance, 2mg of hydromorphone wouldnt give me even a 10% reduction in pain - id get much better relief from a tylenol (and not the ones with codeine!).
Thats just completely silly.
I suspect you should be taking 10-15mg AT LEAST, and I dont mean across the entire span of a day, I mean each dose, doses taken 3-4x a day (or as needed for B/T).
Your doctor is severely underdosing you. Im not exaggerating when I say that 2mg of hydromorphone is similar to 10mg of morphine or 5mg of oxycodone... it would do next to jackall even for someone with minor pain and without an opiate tolerance.
I see this sooo often with hydromorphone, doctors massively UNDERdosing their patients with it. Its given hydromorphone a bad wrap. In reality, hydromorphones effect (and strength of that effect) is similar to fentanyl (even has a similar duration), but only when its actually dosed properly. Your experience with IV hydromorphone doesnt surprise me, they probably gave you a proper dosage of that.
2mg Dilaudids are useless and shouldnt even exist, period. Under no circumstance should anything less than 4mg of hydromorphone be given to ANYONE, except for maybe a 3 year old kid. Someone with an opiate tolerance, almost certainly should never be prescribed anything less than 8mg of hydromorphne to START (and would probably need to increase the dose regardless).
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
#889173 - 05/23/09 05:52 PM
Re: Hydromorphone as breakthrough
[Re: purplemonkey]
|
Newbie
Registered: 09/26/08
Posts: 30
|
meta I was given 10mg of oxycodone in hospital and it knocked me around big time. I felt really strange and totally off my head. I must say though it is absolutely AMAZING for pain. All my pain left. As I said to the nurse, its fab for pain but unfortunately I feel really "stoned" when I take it. I went down to 5mg and found it really great for pain and I could still function. I have had morphine in the past that did nothing. I think OP, oxycodone is probably worth thinking about. With no tolerance though, correct? The OP sounds like hes been on pain management for awhile, and thus certainly has a tolerance built up, hence why I say 2mg of hydromorphone for him, which is going to be similar in relief youd get from 5-10mg of oxycodone, is not going to provide him with much relief because of his tolerance. I mean no one on pain management, meaning theyve been prescribed painkillers for daily use, 24 hours a day of analgesia, for long periods of time (months-years-decades), would get relief from 5-10mg of oxycodone, nor 2mg of hydromorphone.
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
#889234 - 05/24/09 01:29 AM
Re: Hydromorphone as breakthrough
[Re: MrsDoodle]
|
GRAND Pooh-Bah
Registered: 06/08/05
Posts: 2547
|
I have been using hydrocodone (norco) as a breakthrough med for years now. Over the past few months, I have noticed that it gives me zero increased relief. Perhaps a tolerance issue, although I have read that sometimes the body just needs a change up. In any case, when discussing this with the doctor I jokingly said that the best break through relief I ever got was while in the hospital (^ times in the past year) with IV hydromorphone. (Dilaudid) He immediately said "I can give you some oral as break through.' so he switched me off of the Norco onto the oral Dilaudid, 2mgs, three times a day as needed.
I'll admit that I do not know the cross tolerance for the two medications, but I have to say that this medication has been a big fat bust. I have not gotten even a scintilla of extra relief from it. Back in the day when the Norco was still working, when I took it for break through it would lower my pain levels within a half hour by a good two or three levels. The dilaudid does NOTHING.
I vaguely recall reading something about the oral bio-availability about oral dilaudid. Does anyone have any knowledge/experience they can share about this medication?
BTW...I did mention to him that the dilaudid was not giving me any relief (at all!) but I am not going to ask for any kind of change in my pain meds for at least a couple of months. I had also asked for an increase in my anti-depressant at the same time and I want to give that a chance to work. My doctor is great about listening to me and is always willing to work with me. I want him to know that I am willing to work with him and give things a chance to work and also that I understand that pain management does not mean the magic removal of all pain at all times. It is kind of sad, but it is a fact of life that we have to be on guard at all times so that we do not appear to be seeking or scamming. If I had a medication that was not controlling my hypertension well, I would have no trouble calling him as often as it took and changing meds as often as it took, to get it under control. Unfortunately, until the medical establishment, the DEA and even the public understand how dangerous intractable pain is, this is the dance we must dance. Roxicodone 30mg for breakthrew. Dilaudid for everyday relief. 2mg is going to do to much. 8mg triangle tablets are the way to go.
_________________________
CAN I GET A REFILL ON THAT
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
 |
 |
 |
 |
#889255 - 05/24/09 06:57 AM
Re: Hydromorphone as breakthrough
[Re: Repteur]
|
Threadhead
Registered: 08/08/07
Posts: 824
|
I was put on hydromorphone 4mg after years of pain, physical therapy, shots, etc. Did nothing, zippo, zilch. One of our esteemed members (Is it Nephro?) said it doesn't work hardly at all if taken orally, only if given through an IV. I went back to my doctor and he put me on percocets and they did the job. I was really surprised because I thought that hydromorphone would be stronger, but it wasn't.
I think that might be the problem with OPANA IR (oxymorphone). I was changed from percocets for breakthrough, to 5mg of Opana IR. They did nothing. I had to take 10mg to get any relief at all, which of course left me out of them by the middle of the month.
I can say that OPANA ER (long acting) works really well. It's supposed to be 12 hours but it's more like 7-8 hours. That's where your breakthough medicine would have to work until you could take your nighttime dose of Opana ER. Unfortunately, if you have breakthrough pain all throughout the day, then you suffer for several hours until it's time to take the OPana ER again.
Everybody is different. What works for some does nothing for others. Morphine might as well be tylenol on me. I've never had it in an IV, just the ER version at my old PM clinic. They took me off of it quickly because I was freaking out in pain.
The best two long acting pain medicines I've had are Opana ER and Methadone at 10mg 3x a day. I was always given breakthrough medicine also, along with Lyrica, Ambien CR, and Flexeril. I still have tons of Flexeril because I may sleep that night, but I'm going to sleep through most of the next morning too - up until about lunchtime. I can't handle that.
|
|
Top
|
|
|
|
|
 |
 |
 |
 |
|
|