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#886536 - 05/13/09 10:53 PM Hydromorphone as breakthrough
MrsDoodle Offline
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Registered: 04/20/05
Posts: 811
I have been using hydrocodone (norco) as a breakthrough med for years now. Over the past few months, I have noticed that it gives me zero increased relief. Perhaps a tolerance issue, although I have read that sometimes the body just needs a change up. In any case, when discussing this with the doctor I jokingly said that the best break through relief I ever got was while in the hospital (^ times in the past year) with IV hydromorphone. (Dilaudid) He immediately said "I can give you some oral as break through.' so he switched me off of the Norco onto the oral Dilaudid, 2mgs, three times a day as needed.

I'll admit that I do not know the cross tolerance for the two medications, but I have to say that this medication has been a big fat bust. I have not gotten even a scintilla of extra relief from it. Back in the day when the Norco was still working, when I took it for break through it would lower my pain levels within a half hour by a good two or three levels. The dilaudid does NOTHING.

I vaguely recall reading something about the oral bio-availability about oral dilaudid. Does anyone have any knowledge/experience they can share about this medication?

BTW...I did mention to him that the dilaudid was not giving me any relief (at all!) but I am not going to ask for any kind of change in my pain meds for at least a couple of months. I had also asked for an increase in my anti-depressant at the same time and I want to give that a chance to work. My doctor is great about listening to me and is always willing to work with me. I want him to know that I am willing to work with him and give things a chance to work and also that I understand that pain management does not mean the magic removal of all pain at all times. It is kind of sad, but it is a fact of life that we have to be on guard at all times so that we do not appear to be seeking or scamming. If I had a medication that was not controlling my hypertension well, I would have no trouble calling him as often as it took and changing meds as often as it took, to get it under control. Unfortunately, until the medical establishment, the DEA and even the public understand how dangerous intractable pain is, this is the dance we must dance.

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#886658 - 05/14/09 12:39 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
Khilee Offline
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Registered: 03/02/07
Posts: 1679
Loc: TN
Hi MrsDoodle, nice to see that cute little avatar again. I took hydromorphone and it did nothing for my pain. I think it is a form of Morphine and since Morphine has a low bioavailabilty rate, I would think it would be the same with Hydromorphone. Morphine didn't help my pain either. I am currently on Oxycontin with Roxycodone for b/t. It has helped a lot better than the other two. Hope that helped.
Khilee
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#886712 - 05/14/09 02:23 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
nephro Offline
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As Khilee says, bioavailability is the initial problem, but this needn't be the case if the doctors know the equivalences.

For example, for acute pain, 10mg IV morphine = 60mg oral morphine = 1.5mg IV hydromorphone = 7.5mg oral hydromorphone (according to one respected chart).

And that's without opioid tolerance. With tolerance, I suggest that your doc is severely under-dosing the drug.

On the other hand, manufacturers tend not to produce IR analgesics in high doses very much. The UK versions of IR hydromorphone are only produced in 1.3mg and 2.6mg doses. Doctors may dose by looking at what is produced.

Obviously, you shouldn't increase yourself without seeing the doc, etc.


Edited by nephro (05/14/09 02:31 PM)

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#886769 - 05/14/09 04:17 PM Re: Hydromorphone as breakthrough [Re: Khilee]
MrsDoodle Offline
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 Quote:
I think it is a form of Morphine and since Morphine has a low bioavailabilty rate, I would think it would be the same with Hydromorphone. Morphine didn't help my pain either. I am currently on Oxycontin with Roxycodone for b/t. It has helped a lot better than the other two. Hope that helped.
Khilee


Thank you. Yes, that is exactly the kind of experiences I am looking for. When I am hospitalized for intractable pain (the kind where my BP skyrockets to 220/150) my usual IV Dilaudid dosage is 3 mg every 3 hrs IV. I have had a few neophyte nurses too scared to administer that high of dosage and they are always surprised when it does not put me under. Don't get me wrong, it does make me a little drowsy, but mostly it gives me a few hours where I can inhale AND exhale.

A few times I have been put in local hospitals, the community type, and they just flat out refuse to even medicate me with my at home regime. That is always misery. Lot's of misinformation about pain management in the medical community.

Thanks for your input!

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#886774 - 05/14/09 04:27 PM Re: Hydromorphone as breakthrough [Re: nephro]
MrsDoodle Offline
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Registered: 04/20/05
Posts: 811
 Quote:
For example, for acute pain, 10mg IV morphine = 60mg oral morphine = 1.5mg IV hydromorphone = 7.5mg oral hydromorphone (according to one respected chart).

And that's without opioid tolerance. With tolerance, I suggest that your doc is severely under-dosing the drug.


That explains a lot. I am a little surprised at my doc. He is usually better at conversions, although I did get the feeling that hydromorphone is not a medication he often uses for break through. It seems to me that since I get such a good result from the LA Oxy that I would do well with some type of IR Oxy? Since I take Prednisone as part of my daily meds, I don't really see any reason for me to go with any of the meds mixed with ASA, Ibuprofren or tylenol.

And yes, you are correct Nephro. Increasing my own dosage, while oh so tempting, would be ultimately a very bad idea. Hmmm...."Ah? Doc? I tried taking 4 of those little tabs instead of the one you ordered and it worked much better!" I think his response would be "see ya later, Doodle!"

Thanks for the conversions. Now comes the tricky part. Letting my doc in on this little bit of info without sounding as if I am just saying "More! More! More!"

Thanks again.

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#886797 - 05/14/09 05:22 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
Khilee Offline
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 Quote:
It seems to me that since I get such a good result from the LA Oxy that I would do well with some type of IR Oxyy?


You're welcome MrsDoodle. I had been on Opana for b/t. It helped for a while, but not very much. I had the same thought, I wonder if it would be better to be on the same kind of b/t med as my Oxycontin. I got up the nerve to ask my DR. if I could try Oxy IR for b/t and he said he didn't see why not. It has worked out much better. It might be worth a try to ask your Dr. about it. All he can do is say no. I also think maybe it would be easier to calculate the right dosage, since they are the same med. Good luck.
Khilee

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#886802 - 05/14/09 05:44 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
nephro Offline
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 Originally Posted By: MrsDoodle
Since I take Prednisone as part of my daily meds, I don't really see any reason for me to go with any of the meds mixed with ASA, Ibuprofren or tylenol.


I would probably avoid ibuprofen or any other NSAID (including aspirin) with corticosteroids long-term, especially if you have had a stomach ulcer or other gastric condition, but there's no reason to avoid APAP. It may help, and mostly does so when combined with other types of analgesic. Your doc may also be pleased that you're willing to take it, even if only on a PRN or long-term low dose basis.

The modern pain management ethos it to hit the pain from all angles, so to speak.

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#886806 - 05/14/09 05:53 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
kserah Offline

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 Originally Posted By: MrsDoodle
 Quote:
For example, for acute pain, 10mg IV morphine = 60mg oral morphine = 1.5mg IV hydromorphone = 7.5mg oral hydromorphone (according to one respected chart).

And that's without opioid tolerance. With tolerance, I suggest that your doc is severely under-dosing the drug.


That explains a lot. I am a little surprised at my doc. He is usually better at conversions, although I did get the feeling that hydromorphone is not a medication he often uses for break through. It seems to me that since I get such a good result from the LA Oxy that I would do well with some type of IR Oxy? Since I take Prednisone as part of my daily meds, I don't really see any reason for me to go with any of the meds mixed with ASA, Ibuprofren or tylenol.

And yes, you are correct Nephro. Increasing my own dosage, while oh so tempting, would be ultimately a very bad idea. Hmmm...."Ah? Doc? I tried taking 4 of those little tabs instead of the one you ordered and it worked much better!" I think his response would be "see ya later, Doodle!"

Thanks for the conversions. Now comes the tricky part. Letting my doc in on this little bit of info without sounding as if I am just saying "More! More! More!"

Thanks again.


Maybe he's concerned that the hydromorphone won't act as quickly as another product might. As for ibuprofen! They need to put A LOT more warning labels on that! Ibuprofen is contraindicated if you have any type of respiratory difficulty, even allergies. As for your stomach and mixing it with Prednisone--it makes my stomach hurt just thinking about it. I'm down to 20 mg of Prednisone daily. I sure wish it could be less. I don't think that patients are well informed about the side effects--particularly how it affects the mental and emotional status of the client. It's bad enough to have to takeit, but when you start thinking that your normally clear, rational thinking is out of whack because of something you've done, it wallops you with another punch--which we sure don't need!

Glad to see you and your melon head baby on the board, Mrs.D!
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#886834 - 05/14/09 06:58 PM Re: Hydromorphone as breakthrough [Re: kserah]
MrsDoodle Offline
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 Quote:
I'm down to 20 mg of Prednisone daily. I sure wish it could be less. I don't think that patients are well informed about the side effects--particularly how it affects the mental and emotional status of the client.


I am sure that you do the same dance with the devil that I do with Prednisone, right? Up with a flare, wean down, then BAM! Flare time again. In any case, I am only on 5 mgs daily, but I am convinced that even at that low of a dose I am incurring side effects. However, my rheumy has said that since my flares have a tendency to hit the kidneys and heart, he wants me to stay on it indefinately.

Do you think that Pred. affects memory? Causes low level depression?

Sorry...sort of went off topic. I'm so glad you weighed in on this!

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#886884 - 05/14/09 10:40 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
genethebean1 Offline
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I hate prednisone! I was given it once when I was pregnant and having a problem with headaches (long story - crappy doc, blah, blah, blah). After just a few days, I really thought I was going crazy! This was well over 30 years ago so I can't remember exactly what was going on - I just felt like I was losing it! I stopped it and felt better in a day or so. I hope I never have to take it again!
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#889054 - 05/22/09 11:28 PM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
metaomega Offline
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Registered: 09/26/08
Posts: 30
2mg of hydromorphone is virtually nothing, and for a tolerant patient?? Its actually laughable.

Its like taking 10mg of morphine, or 5mg of oxycodone... its such a tiny amount it wouldnt even be given to a 12 year old with a sprained ankle... let alone to someone with an opiate tolerance! Seriously, im very sensitive to pharmacologic agents and even without an opiate tolerance, 2mg of hydromorphone wouldnt give me even a 10% reduction in pain - id get much better relief from a tylenol (and not the ones with codeine!).

Thats just completely silly.

I suspect you should be taking 10-15mg AT LEAST, and I dont mean across the entire span of a day, I mean each dose, doses taken 3-4x a day (or as needed for B/T).


Your doctor is severely underdosing you. Im not exaggerating when I say that 2mg of hydromorphone is similar to 10mg of morphine or 5mg of oxycodone... it would do next to jackall even for someone with minor pain and without an opiate tolerance.



I see this sooo often with hydromorphone, doctors massively UNDERdosing their patients with it. Its given hydromorphone a bad wrap. In reality, hydromorphones effect (and strength of that effect) is similar to fentanyl (even has a similar duration), but only when its actually dosed properly. Your experience with IV hydromorphone doesnt surprise me, they probably gave you a proper dosage of that.

2mg Dilaudids are useless and shouldnt even exist, period. Under no circumstance should anything less than 4mg of hydromorphone be given to ANYONE, except for maybe a 3 year old kid. Someone with an opiate tolerance, almost certainly should never be prescribed anything less than 8mg of hydromorphne to START (and would probably need to increase the dose regardless).

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#889098 - 05/23/09 09:14 AM Re: Hydromorphone as breakthrough [Re: metaomega]
purplemonkey Offline
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meta I was given 10mg of oxycodone in hospital and it knocked me around big time. I felt really strange and totally off my head. I must say though it is absolutely AMAZING for pain. All my pain left. As I said to the nurse, its fab for pain but unfortunately I feel really "stoned" when I take it. I went down to 5mg and found it really great for pain and I could still function. I have had morphine in the past that did nothing. I think OP, oxycodone is probably worth thinking about.
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#889173 - 05/23/09 05:52 PM Re: Hydromorphone as breakthrough [Re: purplemonkey]
metaomega Offline
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Registered: 09/26/08
Posts: 30
 Originally Posted By: purplemonkey
meta I was given 10mg of oxycodone in hospital and it knocked me around big time. I felt really strange and totally off my head. I must say though it is absolutely AMAZING for pain. All my pain left. As I said to the nurse, its fab for pain but unfortunately I feel really "stoned" when I take it. I went down to 5mg and found it really great for pain and I could still function. I have had morphine in the past that did nothing. I think OP, oxycodone is probably worth thinking about.



With no tolerance though, correct?

The OP sounds like hes been on pain management for awhile, and thus certainly has a tolerance built up, hence why I say 2mg of hydromorphone for him, which is going to be similar in relief youd get from 5-10mg of oxycodone, is not going to provide him with much relief because of his tolerance.


I mean no one on pain management, meaning theyve been prescribed painkillers for daily use, 24 hours a day of analgesia, for long periods of time (months-years-decades), would get relief from 5-10mg of oxycodone, nor 2mg of hydromorphone.

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#889234 - 05/24/09 01:29 AM Re: Hydromorphone as breakthrough [Re: MrsDoodle]
Repteur Offline
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Registered: 06/08/05
Posts: 2547
 Originally Posted By: MrsDoodle
I have been using hydrocodone (norco) as a breakthrough med for years now. Over the past few months, I have noticed that it gives me zero increased relief. Perhaps a tolerance issue, although I have read that sometimes the body just needs a change up. In any case, when discussing this with the doctor I jokingly said that the best break through relief I ever got was while in the hospital (^ times in the past year) with IV hydromorphone. (Dilaudid) He immediately said "I can give you some oral as break through.' so he switched me off of the Norco onto the oral Dilaudid, 2mgs, three times a day as needed.

I'll admit that I do not know the cross tolerance for the two medications, but I have to say that this medication has been a big fat bust. I have not gotten even a scintilla of extra relief from it. Back in the day when the Norco was still working, when I took it for break through it would lower my pain levels within a half hour by a good two or three levels. The dilaudid does NOTHING.

I vaguely recall reading something about the oral bio-availability about oral dilaudid. Does anyone have any knowledge/experience they can share about this medication?

BTW...I did mention to him that the dilaudid was not giving me any relief (at all!) but I am not going to ask for any kind of change in my pain meds for at least a couple of months. I had also asked for an increase in my anti-depressant at the same time and I want to give that a chance to work. My doctor is great about listening to me and is always willing to work with me. I want him to know that I am willing to work with him and give things a chance to work and also that I understand that pain management does not mean the magic removal of all pain at all times. It is kind of sad, but it is a fact of life that we have to be on guard at all times so that we do not appear to be seeking or scamming. If I had a medication that was not controlling my hypertension well, I would have no trouble calling him as often as it took and changing meds as often as it took, to get it under control. Unfortunately, until the medical establishment, the DEA and even the public understand how dangerous intractable pain is, this is the dance we must dance.


Roxicodone 30mg for breakthrew. Dilaudid for everyday relief. 2mg is going to do to much. 8mg triangle tablets are the way to go.
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#889255 - 05/24/09 06:57 AM Re: Hydromorphone as breakthrough [Re: Repteur]
Lynx4 Offline
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Registered: 08/08/07
Posts: 824
I was put on hydromorphone 4mg after years of pain, physical therapy, shots, etc. Did nothing, zippo, zilch. One of our esteemed members (Is it Nephro?) said it doesn't work hardly at all if taken orally, only if given through an IV. I went back to my doctor and he put me on percocets and they did the job. I was really surprised because I thought that hydromorphone would be stronger, but it wasn't.

I think that might be the problem with OPANA IR (oxymorphone). I was changed from percocets for breakthrough, to 5mg of Opana IR. They did nothing. I had to take 10mg to get any relief at all, which of course left me out of them by the middle of the month.

I can say that OPANA ER (long acting) works really well. It's supposed to be 12 hours but it's more like 7-8 hours. That's where your breakthough medicine would have to work until you could take your nighttime dose of Opana ER. Unfortunately, if you have breakthrough pain all throughout the day, then you suffer for several hours until it's time to take the OPana ER again.

Everybody is different. What works for some does nothing for others. Morphine might as well be tylenol on me. I've never had it in an IV, just the ER version at my old PM clinic. They took me off of it quickly because I was freaking out in pain.

The best two long acting pain medicines I've had are Opana ER and Methadone at 10mg 3x a day. I was always given breakthrough medicine also, along with Lyrica, Ambien CR, and Flexeril. I still have tons of Flexeril because I may sleep that night, but I'm going to sleep through most of the next morning too - up until about lunchtime. I can't handle that.

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#889262 - 05/24/09 08:43 AM Re: Hydromorphone as breakthrough [Re: Lynx4]
nephro Offline
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Hydromorphone has poor bioavailability orally, as does morphine and diamorphine, but dosages should be adjusted for that. The low-dose preparations such as 1.3mg hydromorphone or 10mg morphine are available for those with renal or hepatic impairment, or the elderly and frail.

It's just that doctors look at these small doses and think that they must be powerful drugs - which they are - but have to be dosed correctly.

It is acceptable to start on the lowest produced dose for patients new to opioids, but not when the patient is already opioid tolerant, and even then, there shouldn't be too much hesitation in increasing according to response.

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#889357 - 05/24/09 05:39 PM Re: Hydromorphone as breakthrough [Re: nephro]
Milvus Offline
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I wish my present pain management doctor understood this, Nephro. He won't even prescribe codeine unless you're a cancer patient (a fat lot of good codeine is going to do for cancer pain). He also told me he doesn't prescribe morphine unless he absolutely has to, as he reckons it's so addictive and says that once its effectiveness wears off there isn't anything else to offer a patient for pain relief. Guess he's never heard of hydromorphone, methadone, fentanyl....

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#889359 - 05/24/09 05:48 PM Re: Hydromorphone as breakthrough [Re: Milvus]
nephro Offline
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That's crazy. When the effectiveness of morphine wears off, you give more morphine, and the effectiveness is restored. There is no ceiling. Of course such a condition warranting indefinitely escalating doses is usually without a cure, but not necessarily terminal.

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#950509 - 10/28/09 04:08 PM Re: Hydromorphone as breakthrough [Re: nephro]
SexieLexie Offline
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Registered: 10/28/09
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I wish i had some dilaudid or oxycontin!!!

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#950795 - 10/28/09 11:20 PM Re: Hydromorphone as breakthrough [Re: SexieLexie]
DeeRock Offline
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I think anything with the word "morphine" or "morphone" in it is all weak orally when you can take a fraction of the oral dose IV and have very good analgesic. orally they have the first-pass where you lose most of the medicine.
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#951423 - 10/29/09 04:07 PM Re: Hydromorphone as breakthrough [Re: nephro]
PNWRain Offline
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Nephro - probably because of liver failure, my ER Morphine Sulfate works OK. In face, I HATE take it. I get tired easily and then the meds make me sleepy. I hate that. But the hibbie jibbies are worse, as is the pain.

Ms Doodle, I hope you are doing well. Does the Hydromorphone provide any relief? So good to "see" you.

Happy Thursday to everyone.

Rain

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#951533 - 10/29/09 06:30 PM Re: Hydromorphone as breakthrough [Re: Milvus]
meonlyits Offline
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Originally Posted By: Milvus
I wish my present pain management doctor understood this, Nephro. He won't even prescribe codeine unless you're a cancer patient (a fat lot of good codeine is going to do for cancer pain).


Wow, that is insane. There should be minimum standards of care regarding pain medicine. I know pain is hard to measure but not in all cases.
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