Codeine is an alkaloid obtained from opium or prepared from morphine by methylation and occurs as white crystals. Codeine effloresces slowly in dry air and is effected by light. The chemical name of codeine phosphate is 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol phosphate (1:1)(salt) hemihydrate and has the empirical formula of C18H21NO3·H3PO4·1/2H20. Its molecular weight is 406.4.

Each soluble tablet contains 30 mg (0.074 mmol) or 60 mg (0.15 mmol) of codeine phosphate. These tablets also contain lactose and sucrose.

Soluble tablets of codeine phosphate are freely soluble in water. They are intended for the preparation of solutions for parenteral administration. These tablets are not sterile. Codeine phosphate is an analgesic.


INDICATIONS

Codeine phosphate is an analgesic indicated for the relief of mild to moderate pain.


DOSAGE AND ADMINISTRATION

For Analgesia: Dosage should be adjusted according to the severity of the pain and the response of the patient.

Adults: 15 to 60 mg every 4 to 6 hours (usual adult dose, 30 mg).

Children: 1 Year of Age and Older - 0.5 mg/kg of b.d. weight or 15 mg/m2 of b.d. surface every 4 to 6 hours.

Soluble tablets codeine phosphate are administered subcutaneously or intramuscularly.

Solutions for injection should be prepared with sterile water and filtered through a 0.22 membrane filter.

Note: Do not use the solution if it is more than slightly discolored or contains a precipitate.


PATIENT INFORMATION

Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics, phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.

Whats the difference between codeine phosphate and codeine sulphate?

thanks!

nikki

There is not too much difference between the phosphate and sulphate. The phospate will be slightly weaker on a mg to mg basis because the base molicule weighs more than the sulpher. It's strange but morphine is usually done as a sulphate and codeine is done as a PHOSPATE.

I find this to be the best asthma medication there is, I know it's not commonly found on Western markets, but having purchased Codine Sulphate in France and taken it at times when I have asthma issues (which is very often), it's been a great help to me.

How much tynenol doesezch tylenol 4 have in it? It says the 60 mg of codeine but does not indicate amount of codeine.I ussually take norco 10/325 but has to switch to the tynenol 4 for a bit to decrease tolerance to the hydro codone. It is not as strong but it keeps the pain at bay just concerned about the amount of tylenol. Anybody know? I even researched it and could not find the answer!
Thanks!

Codeine Phosphate (C18 H21 NO3). H3PO4 . 1 1/2 H2O mw424
Codeine Sulfate (C18 H21 NO3)2 . H2SO4 . 5H2O mw786

per molecule of codeine base, the phosphate is 8% heavier. Therefore in a mass comparison, the sulfate is a little stronger. If you can accurately cut your pills into 12 parts, you could make up for it.

Chemistry major???? I rarely see someone post re molecular weights and chemical composition on this board - and you live in the Ozarks???? Just teasing - couldn't resist:) I really enjoy your posts - you are a very knowledgable person!

Anyone have a rough idea of the comparative narcotic strength of Codeine to Hydrocodone or vice-versa? For example, how many Tylenol #3 30 mg codeine would equal 1 Hydro 10/325? Thanks.

Yes.... used to take hydro 10/325 in us. cannot get in europe. takes 60-90mg of codeine to even come close for me... truth is it is good but not as good... doesn't last as long either. But it's all I can get and it works. Sorry can't give exact details for you just from experience. Bye!

Codiene has a shorter half life. It also has less sedative effect. mg to mg it's suppose to be 8 to 1.

there isn't really a comparison

Had to get Tylenol 3 due to it being so much cheaper than Hydro. How much to compare and also, has anyone noticed upset stomach on it, more so than hydro.

Thanks,
ME

Codeine works great in the treatment of narcolepsy. It has a paradoxel effect, it helps to keep narcoleptics awake without the side effects that ritalyn has.

if you wanna get down down on the ground use 50mg codine but don't forget this fact 'you can't get it back codine'

What?

just be cautious. i believe it is a schedule II med as just plain codeine, but when one purchases it with the tylenol, it drops to a schedule III.
for emergency, codeine is imperative in terms of bronchitis (only take at night to sleep;if one takes it to suppress cough all day, then one can develop pneumonia,) and is better for headaches/migraines than hydro which can worsen headaches in some [but not as good as butalbital, with or without the codeine for headaches/migraines.] If one can get the tylenol #4, 60 mg. codeine, then break in half, one has double the pills of tylenol #3. This does help with pain, but will not give certain effects (at least I don't believe it will) that some people anticipated from the hydro. Another pain killer is talwin, pentazocine,sosegon, schedule IV with tylenol, and it does work, particularly on dental pain. both are cheaper and but for the codeine cough syrup mentioned in the NDS indictment, are under less scrutiny at present.

It is scheduled by the amount of codeine, I don't have the link in front of me, but you can find out....I think one of the links on the DB page will direct you to the scheduling page and it breaks it down so it's easy to read.

Codeine’s comparative analgesia to hydro is 6/1

So 60mg codeine = 10 mg hydro

Duration of hydro may be up to 2 hours longer than codeine

Just google opioid equivalency chart and you'll see where I'm getting this info.

Things that Potentiate Codeine (/Enhance Experience):

-DXM/ketamine (therapeutic amount, ie. Amount normally taken for cough)
-wine - white, not red (small amount) or brandy/rum/vodka
-antihistamines ie.benadryl (25-75mg), original Dramamine,Phenyltoloxamine Citrate (2x therapeutic dose)
-antacids ie. Sodium bicarbonate mixed into narcotic solution
-benzodiazapines (therapeutic dose)
-belladona alkaloids - scopolamine especially (therapeutic dose)
-Nyquil mix (due to DXM and doxylamine)
-St Johns Wort

Please help! I got codeine phosphate and the description says that it's water soluble. I was under the impression that I was to drink it like Alka-Seltzer, but now that I've been online it seems like it's for injection use only. Is this true? Can you not drink a water soluble codeine phosphate tablet? I'm so confused. And I don't really have the means to do it any other way. If anyone has the proper info on this matter, please help! Thanks.

whats the name of the codeine product.
The UK has several that are like alka seltzer
one call soldapiene (sp?) comes to mind

Wow. I hope you didn't do this. Codeine comes in effervescent tabs that are meant to be dissolved in liquid and drunk.

Injecting codeine can kill you. Seriously. Pulmonary embolism, badda-boom!

INTRAVENOUS injection of codiene can cause pulmonary edema
but injection sc (sub cutaneous just under the skin) or IM
injection (into the butt thigh or upper arm) can be & is given in that manner, IM & SC routes.

Hello all,

Has anybody here know what this is exactly? Is it a pill to be taken orally or disolved in a liquid?

Codeine/paracetamol (COD-Efferalgan) 30/500 mg

Thanks,

BBM

sounds like one of the products sold OTC in New Zealand. I'v never taken it, but have seen it listed on a product page w/ Nurpfen+ and the likes..........I'm assuming you swallow it like any regular pill. Something that's meant to be dissolved, such as Solpadeine, states so clearly in the product literature.

My Doc has had me on T3's for cluster headaches for about 3 months, I have developed a very high tolerance to the codeine and was wondering how much codeine is safe to take in one single dose????

Thanks