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#84922 - 03/08/04 05:42 AM
Ultram - Tramadol
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Moderator
Pooh-Bah
Registered: 03/20/03
Posts: 1378
Loc: DrugBuyers.Com
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Tramadol hydrochloride is a centrally acting analgesic. The chemical name for Tramadol hydrochloride is (±)cis-2- [(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride. The molecular weight of Tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The water/n-octanol partition coefficient is 1.35 at pH 7. Ultram tablets contain 50 mg of Tramadol hydrochloride and are white in color. Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax. INDICATIONS Tramadol is indicated for the management of moderate to moderately severe pain. DOSAGE AND ADMINISTRATION For the treatment of painful conditions Tramadol 50 mg to 100 mg can be administered as needed for relief every four to six hours, not to exceed 400 mg per day. For moderate pain Tramadol 50 mg may be adequate as the initial dose, and for more severe pain, Tramadol 100 mg is usually more effective as the initial dose. Individualization of Dose: Available data do not suggest that a dosage adjustment is necessary in elderly patients 65 to 75 years of age unless they also have renal or hepatic impairment. For elderly patients over 75 years old, not more than 300 mg/day in divided doses as above is recommended. In all patients with creatine clearance less than 30 ml/min, it is recommended that the dosing interval of Tramadol HCl be increased to 12 hours with a maximum daily dose of 200 mg. Since only 7% of an administered dose is removed by hemodialysis, dialysis patients can receive their regular dose on the day of dialysis. The recommended dose for patients with cirrhosis is 50 mg every 12 hours. Patients receiving chronic carbamazepine doses up to 800 mg daily may require up to twice the recommended dose of Tramadol HCl. HOW SUPPLIED Ultram 50 mg (white, film-coated capsule-shaped tablet) is engraved "McNeil" on one side and "659" on the other side. Dispense in a tight container. Store at controlled room temperature (up to 25°C, 77°F). PATIENT INFORMATION Tramadol HCl is used to relieve moderate to severe pain. This drug should be used as directed and only for the period of time determined by the physician. This drug can cause dizziness or tiredness and in some cases nausea, constipation and headache. Avoid the use of alcohol or other depressants such as sleeping pills or tranquilizers. Be especially careful when performing potentially hazardous tasks such as driving or operating machinery while taking this drug. Please tell your pharmacist or physician if you are pregnant or nursing.
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#84923 - 04/19/06 03:35 PM
Re: Ultram - Tramadol
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Administrator
GRAND Pooh-Bah
Registered: 11/18/01
Posts: 6370
Loc: DrugBuyers.Com
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http://www.deadiversion.usdoj.gov/drugs_concern/tramadol.htm Drugs and Chemicals of Concern Quote:
Tramadol (Trade Name: Ultram®)
July 2004
DEA/OD/ODE/200407/27
Introduction:
Tramadol was approved for marketing as a noncontrolled analgesic in 1995 under the trade name of Ultram®. Although the company initially claimed that this substance produced only very weak narcotic effects, recent data demonstrates that opioid activity is the overriding contributor to the drug’s pharmacological activity. Because of inadequate product labeling and lack of established abuse potential, many physicians felt this drug was perfectly safe to prescribe to recovering narcotic addicts and to known narcotic abusers. As a consequence, a large number of reports of abuse and dependence have been received.
Licit Uses:
Tramadol is approved for the treatment of moderate to moderately severe pain in adults. Although FDA has still not recommended the scheduling of this substance in the Controlled Substances Act (CSA), a requirement necessary for DEA to place a substance under control, they have required the company to inform physicians about recent abuse data and to include new information under the "drug Abuse and Dependence" section in the approved labeling. The labeling now contains the following language:
"Ultram® has a potential to cause psychic and physical dependence of the morphine-type (μ-opioid). The drug is associated with craving, drug-seeking behavior and tolerance development. Cases of abuse and dependence on Ultram® have been reported. Ultram® should not be used in opioid-dependent patients. Ultram® can reinitiate physical dependence in patients that have been previously dependent or chronically using other opioids. In patients with a tendency to drug abuse, a history of drug dependence, or are chronically using opioids, treatment with Ultram® is not recommended."
Chemistry/Pharmacology:
Tramadol is a centrally acting synthetic opioid. Opioid activity is due to both the parent compound and the more active O-desmethylated metabolite. Apart from analgesia, Tramadol may produce a number of symptoms including dizziness, somnolence, nausea, and constipation similar to other opioids.
Tramadol is well absorbed orally. It can be administered in 50 to 100 mg doses as needed for pain relief every 4 to 6 hours, not to exceed 400 mg/day. Seizures have been reported in patients receiving recommended doses but are more likely in high doses associated with abuse of this medication.
Poison Control data (2002 AAPCC Annual Report) indicates that there were 2,400 exposures of Tramadol reported to poison control centers. Of those, 108 resulted in a major medical outcome and 8 resulted in death.
Illicit Uses:
Tramadol is abused for its opiate effects. The drug Abuse Warning Network (DAWN) is a database which provides data on drug related episodes reported by hospital emergency rooms. In 2002, there were 1,714 episodes for Tramadol and a total of 7,890 episodes from 1998 through 2002. DAWN medical examiners reported that Tramadol was involved in 95 drug-related deaths in 2002 and a total of 382 deaths from 1998 through 2002.
The National Forensic Laboratory System (NFLIS) and System to Retrieve drug Evidence (STRIDE) are both DEA databases that collect scientifically verified data on analyzed samples in state/local and DEA forensic laboratories, respectively. In 2003, there were 267 exhibits of Tramadol in NFLIS and 2 exhibits in STRIDE. These relatively small numbers are most probably a reflection of the uncontrolled status of Tramadol in the U.S.
User Population:
The current pattern of Tramadol abuse in the US involves street drug addicts, chronic pain patients, and health professionals. The lack of control and lack of urine toxicology screen for this medication have probably contributed significantly to the availability of this drug.
Illicit distribution:
Like other legal pharmaceuticals with abuse potential, diversion of this medication occurs in a number of ways including prescription fraud. As an uncontrolled substance, there are no CSA regulations regarding manufacturing, distribution, or prescription of this medication.
Control status:
Tramadol is not controlled under the CSA but is under review for possible control.
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#84930 - 07/19/06 04:07 AM
Re: Ultram - Tramadol
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Banned
Registered: 07/05/06
Posts: 80
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I used to take Tramadol for my PHN (post herpetic neuralgia) but take lortab 10 now. The Tramadol wasn't as effective for the pain but it definately was a better mood elevator. I took 100mgs when i woke up in the morning followed by 50mg increments throughout the day. Tramadol seems to last very long so you will always have some steady pain relief if you take it consistently. I am considering trying to combine low doses of Tramadol with the lortab 10. I am going to talk to my doctor about it the next time I have a consult. He will probably not want to do overlapping treatments but its worth asking about. Anyone who is looking for some pain relief this stuff is the best you will find without a prescription. It's very cheap too.
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#84931 - 11/17/06 11:32 AM
Re: Ultram - Tramadol
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Member
Registered: 08/05/05
Posts: 185
Loc: NC
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Thought I would post this just as FYI. I've seen sveral generic versions of Tramadol and thought I would start a thread where the various generics could be listed as to shape and imprint; 1. round with COR 127 2. oblong with 377 3. oval with 93 on 1 side and 58 on the other 4. small oblong that I can't remember imprint for 5. flatter oval whose markings I can't remember I know there are more so if anyone can add then please do.
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#84933 - 11/18/06 12:41 PM
Re: Ultram - Tramadol
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Board Addict
Registered: 10/22/04
Posts: 327
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Quote:
5. flatter oval whose markings I can't remember
PLIVA 616 markings on one side, no markings on the other.
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#84936 - 01/06/07 09:01 PM
Re: Ultram - Tramadol
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Board Addict
Registered: 09/26/06
Posts: 277
Loc: North Carolina
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Quote:
I used to take Tramadol for my PHN (post herpetic neuralgia) but take lortab 10 now. The Tramadol wasn't as effective for the pain but it definately was a better mood elevator. I took 100mgs when i woke up in the morning followed by 50mg increments throughout the day. Tramadol seems to last very long so you will always have some steady pain relief if you take it consistently.
I am considering trying to combine low doses of Tramadol with the lortab 10. I am going to talk to my doctor about it the next time I have a consult. He will probably not want to do overlapping treatments but its worth asking about.
Anyone who is looking for some pain relief this stuff is the best you will find without a prescription. It's very cheap too.
Please, definitely talk to your Doc before combining Tramadol with anything else, especially the Lortabs. I've heard of severe reactions when combining Tramadol/Ultram with some other meds. Some people even have seizures. Just be careful, ok??
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#84937 - 01/06/07 09:56 PM
Re: Ultram - Tramadol
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GRAND Pooh-Bah
Registered: 09/04/06
Posts: 9709
Loc: NOT 40!
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Quote:
Ultram or Tramadol have NO narcotic effect whatsoever. NADA. These posts about it are hilarious, because people have been snowed, conned, convinced they get a narcotic effect from this drug. Oh Lord, what will they come up with next?
Sorry if I rained on anyone's parade. RR
Tramadol has a weak affinity for the mu-opioid receptor, therefore having some narcotic effect but not as much as weak opioids such as codeine.
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#84938 - 01/06/07 10:02 PM
Re: Ultram - Tramadol
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Member
Registered: 12/17/05
Posts: 163
Loc: TX
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It may be true in fact that there is no narcotic "effect" using Tramadol but I have to say I've been finding Tramadol very useful to help control pain I've had for a few years in my shoulder and help transition away from hydro. I still take hydro for severe pain, but Tramadol seems to work for me very well on "not so bad days" and I've been able to start going days at a time now without taking any hydro at all.  I've been taking hydro almost daily for about two years now and have been afraid of the WD's and short supply of hydro (or ridiculous expense if you can find it at all.) Tramadol has been a lifesaver for me so far... No, Tramadol isn't going to give you much of a buzz or "high" but sorry, that's not why we're here. It does, for me, seem to dull the pain a good amount. I'd highly recommend if you're looking for an alternative to hydro. I think it's just different effects for different people, nobody is getting "snowballed." For example, for some reason when I do go to the doc, I usually get Darvocet, which is completely worthless to me. It gives me a bit of a "buzz" (along with a nauseous feeling)but does not do much in the way of dulling pain, for me at least. I know many people find Darvocet to be very effective for them. To each his or her own. Good luck! FYI, the 100mg Tramadol I've got right now is from Starlite, which is the original name brand, so they say. Funny thing is, since it is not controlled, it was not seized by customs. I got 1/2 packages from Joe... First one came through fine with my 75 Rivotril but the second came with a LL and the Rivotril gone but they left me the Tramadol that was in the same package. I thought that to be odd, since they say "ordering any meds overseas can be dangerous- you don't know what you're getting." These Tramadol, as I mentioned in another post, look like they could be tabs of anything. Point being, if you're looking for an alternative for hydro or other pain med (not for getting a "buzz") try IOP's and you can get Tramadol (100mg or better, 50mg are only available in the states), name brand and reasonably priced without fear of having them seized. Not bad, IMO. Good luck, hope that will help some!
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#84939 - 01/06/07 10:08 PM
Re: Ultram - Tramadol
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Member
Registered: 12/17/05
Posts: 163
Loc: TX
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Quote:
Quote:
I used to take Tramadol for my PHN (post herpetic neuralgia) but take lortab 10 now. The Tramadol wasn't as effective for the pain but it definately was a better mood elevator. I took 100mgs when i woke up in the morning followed by 50mg increments throughout the day. Tramadol seems to last very long so you will always have some steady pain relief if you take it consistently.
I am considering trying to combine low doses of Tramadol with the lortab 10. I am going to talk to my doctor about it the next time I have a consult. He will probably not want to do overlapping treatments but its worth asking about.
Anyone who is looking for some pain relief this stuff is the best you will find without a prescription. It's very cheap too.
Please, definitely talk to your Doc before combining Tramadol with anything else, especially the Lortabs. I've heard of severe reactions when combining Tramadol/Ultram with some other meds. Some people even have seizures. Just be careful, ok??
Anyone have any insight into this? As I mentioned in my previous post, I've been transitioning a bit from hydro to Tramadol but on some days I may take a 100mg Tramadol in the morning, have a "bad" day pain wise and take a 10/325 for severe pain (or half of one if it's not unbearably bad.) I don't take them at the same time, usually several hours apart but sometimes in the same day, at least. Anyone know of any specific reactions to having both in the system at the same time? I've not found any specific contradictions online but I am no doctor. Thanks as always!
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#84940 - 01/07/07 01:07 AM
Re: Ultram - Tramadol
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Veteran
Registered: 03/02/02
Posts: 359
Loc: troposphere
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I've been taking Tramadol for some time. Occasionally I get a few hydros in between. Last time, when I had a surgical procedure done, I stop the Tramadol, take the hydros only, and then go back to Tramadol. But have taken both the same day, too, and when you do that you can't almost feel the hydros at all. As to seizures, doing this did not in the least give me any problems. But taking too much Tramadol will let you know how dangerous this stuff is. I can't believe how high the doses some people here are taking. I could and would never do this. Tramadol with hydros together is okay, but high doses of Tramadol with hydros or without hydros probably wouldn't be okay at all.
Tramadol doesn't work fast and powerfully like hydros. It begins to work well when taken for some time. Real well. But it is a very dangerous drug, nevertheless.
Edited by chantal (01/07/07 01:20 AM)
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#84941 - 01/07/07 03:09 AM
Re: Ultram - Tramadol
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Member
Registered: 01/05/06
Posts: 133
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Quote:
I've been taking Tramadol for some time. Occasionally I get a few hydros in between. Last time, when I had a surgical procedure done, I stop the Tramadol, take the hydros only, and then go back to Tramadol. But have taken both the same day, too, and when you do that you can't almost feel the hydros at all. As to seizures, doing this did not in the least give me any problems. But taking too much Tramadol will let you know how dangerous this stuff is. I can't believe how high the doses some people here are taking. I could and would never do this. Tramadol with hydros together is okay, but high doses of Tramadol with hydros or without hydros probably wouldn't be okay at all.
Tramadol doesn't work fast and powerfully like hydros. It begins to work well when taken for some time. Real well. But it is a very dangerous drug, nevertheless.
I agree with Chantal 100 %. Sometimes you can use Tramadol to help taper off if you have been on Hrydro for a while and can no longer get them for what ever reason, but to take them together it can be quite dangerous. They are two of the same, although in your mind Hydro "feels" much better. (Does that make scence?) Hydro gives you a "buzz" Tramadol doesn't (atleast for me) but they are two of the same...to mix them and take too much of each can be a really bad combo....Dawn
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#84946 - 03/25/07 11:31 AM
Re: Ultram - Tramadol
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Stranger
Registered: 12/04/06
Posts: 7
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Hi all, Just started taking Tramadol HCL for moderate to severe arthritis in my spine. Two 50 mgs tabs did NOT take away my pain, but three DID, with no side effects whatsoever. I almost felt as though I'd gotten my life back. My concern, however, is tolerance. I'm at the 400 mg threshold now and it doesn't seem to be working as well as it did when I started taking it a week ago. FYI: I'm a big person and am wondering if it's possible for me to safely take more of it or whether that's a dumb idea. Any advice (what to ask/tell my doctor)? Overall, this is a good medication. Thanks in advance!
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#84948 - 03/25/07 02:24 PM
Re: Ultram - Tramadol
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Stranger
Registered: 12/04/06
Posts: 7
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#84972 - 04/12/07 11:43 AM
Re: Ultram - Tramadol
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Enthusiast
Registered: 04/19/06
Posts: 218
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I have heard, and can personally verify, that Tramadol sort of "offsets" the effects of Hydrocodone because it works on the same receptors. If this is true, then I would guess it would also be true for Tylenol 3. So, you might be "negating" the effects of your T3, not extending them. I am not a Doctor, I don't play one on TV and at DB.com I am only spewing forth my opinions, repeating rumors and hearsay. So, do not ever say, "Well, Swizzelstick says....", because most likely I probably "made up" whatever it is you might repeat.  ~ Swizzel
_________________________
Remembering that Keith Richards is still alive makes me breath a sigh of relief.
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#84976 - 05/29/07 12:39 PM
Re: Ultram - Tramadol
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Threadhead
Registered: 12/01/05
Posts: 732
Loc: United States
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Quote:
I have heard, and can personally verify, that Tramadol sort of "offsets" the effects of Hydrocodone because it works on the same receptors.
If this is true, then I would guess it would also be true for Tylenol 3. So, you might be "negating" the effects of your T3, not extending them.
I am not a Doctor, I don't play one on TV and at DB.com I am only spewing forth my opinions, repeating rumors and hearsay.
So, do not ever say, "Well, Swizzelstick says....", because most likely I probably "made up" whatever it is you might repeat.
~ Swizzel
Swizzel,
You are indeed correct, it is not just anecdotal or your opinion but fact. It is posted on WebMD and in the PDR.
Ultram (Tramadol Hcl), and Ultracet (Tramadol with apap) binds with mu1 and tends to block mu2 to a lesser degree with no kappa binding at all. Most opiods bind with mu1 and mu2 primarily and some with mu1, mu2 and kappa1. So if you take Ultram and a true opiod, the Ultram and the other opiod are both competing for the same receptors in the brain. The only thing we don't know for sure is which one is going to win out in the competition!!!!
Frankly, most of the docs I know don't recommend using Ultram with other opiods. You can safely take it with NSAIDS like Aleve or Motrin though. Remember a couple of things that are different with Ultram as opposed to other pain relievers..... Ultram does indeed have some mild to moderate SSRI properties, so if someone is on an SSRI for depression, OCD etc. like Prozac, Paxil, Luvox and the like, one could develop serotonin syndrome which is uncomfortable. That is too much build up of serotonin in the synaptic spaces.
There is one other problem you must keep in mind with Ultram, please watch your dosage. If Ultram is taken in too high a dose it lowers the seizure threshold and you could wind up having convulsions.
A very good ER doc I know wound up with an addiction to opiates. He is clean and sober over 3 years now, but he did have a bad problem. He tried to detox himself from percocet and hydromorphone using Ultram. He took very high doses, over 300mg per dose several times a day. He wound up having a full generalized motor seizure in the middle of the emergency department floor.
Thank goodness he entered an inpatient program for impaired physicians in the Atlanta Ga. area and is doing great now, but just a bit of a cautionary tale.
_________________________
"They who would give up an essential liberty for temporary security, deserve neither liberty or security," Benjamin Franklin
I am not a Real Doctor but I play one on DB
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#84977 - 06/11/07 07:58 AM
I know this drug and these are facts
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Newbie
Registered: 06/11/04
Posts: 40
Loc: a nice place to live
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Hi. I have been taking Tramadol for about three years steadily. I have had low doses and given myself very high doses. With this in mind, just realize that every person's body reacts differently to a medication. I never had a seizure no matter how many I took. Constipation, on the other hand, was awful. Never had that before this med. 1. This med is a mild pain reliever and never realy worked well for the pain. However, for depression, it is terrific (things that doctors do not know... remember, most M.D.'s are stupid and only have that degree because their family was wealthy... they do not even try what they prescribe). That said, Tramadol ( Ultram) has a mild opiate effect and also has a mild antidepressant effect as it provides a bit of norepinephine and serotonin reuptake. The result is that this pill is a great well-being pill. No need for antidepressants along with it for that is a bad combination. I also do not drink much... but I would say that alcohol might up the seizure potential. BE CAREFUL WITH THIS AND ALCOHOl. 2. Now, the tendency is to continue to take more in order to get the same effect. It is in this way that it is addictive and will be a controlled substance ala the narcotics soon. Docs are waking up to the fact that the pill is waay addictive with awful withdrawals if you go cold turkey. Clients are calling in and reporting trouble coming off. I know. I was taking 30 to 40 a day with no problem but cost and waking up the next morning feeling depressed. Additionally, it does cause constipation and prolongs the sexual ability to ejaculate (could be a godsend to some; but I found that at large dosages, I was having a hard time keeping erections or even having them... of course, you will not read that anywhere... but it is true). So, the med is not perfect, but it really helps the mood and is further elevated by 420. 3. Withdrawal is a pain in the behind. No different from any narcotic and they even prescribe methadone-like drugs (suboxone) to help you get off the [censored] thing. I remember once when I was almost out of this med and had been taking a lot and boy those were tough withdrawals. I woke up in the middle of the night and it felt like my entire nervous system was on fire. Two pills and it was gone. But BE CAREFUL please!! This little pill is nothing to fool with and you do not want the withdrawals. At a low dose, it might even begin to bother you as it pushes you for more. Yet, the low dose withdrawal is not bad if you have something to wean you off like a benzo or another opiate. 4. It does affect sleep. Very odd is this. It puts you in a "reverie"... a dreamlike state between waking and sleeping. Actually, it is pleasant experience and I never worried about going to sleep. 5. Finally, I loved taking this drug as it promoted my enjoying this life more and I was very functional. One does not feel much different than normal but much happier. I could do anything... drive, write, speak... no sweat. Yet, there comes a time when the money outlay is considerable and the addiction FACT has hit home and, at that point, you are traversing a chasm you might not want to cross. AND there is resultant depression the next day until you take some (which could be as much as 12 at a time even though the dosage is recommended to be no more than 8 a day). It makes me wonder why the medical community and the government are allowing this when they must know the effects of the med. It will not wipe you out like cocaine or heroin, but it can wreak havoc if you use too much. I like it. It is a good drug as an antidepressant and very mild pain reliever. However, I do not know if I can afford the cost and the withdrawals to continue. Currently, I am off and I do miss it. My life has not been an easy one and it is great to find something that promotes some well-being in the midst of this world that has gone nuts. What happened to freedom around this world? You work your buns off to get from paycheck to paycheck and the alcohol/cigarettes thing is a legal poisoning. Man.... I am not surprised that anyone would seek some relief from these gas prices and the constant lies by the government. So, Tramadol can be a substance that is calming. I liked to have it with a benzo so that the feeling is really controlled. Yet, it has its downfalls like all things foreign to the body. So, be careful and take care of yourself. This thing can sneak up on you and you will find that it becomes a part of your life.
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#571241 - 09/28/07 01:23 PM
Re: Ultram - Tramadol
[Re: 1kidsmom]
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Stranger
Registered: 08/21/07
Posts: 14
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Does anyone know if it's safe to take Aleve with Ultram? Aleve (naproxen) is an NSAID. Tramadol does not interact with NSAIDs, so Aleve can be used with Ultram. Tramadol worked great for me for postoperative pain and was not sedating. And I read the story that Tramadol produced noticeable antidepressant effect when SSRIs failed.
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#639561 - 01/28/08 07:57 PM
Re: Ultram - Tramadol
[Re: Melody]
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Newbie
Registered: 01/12/06
Posts: 27
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Tramadol is a great drug when used for a legitimate medical condition. I have had fibromyalgia for about 14 years. I was on every time of arthritis drug including those that are no longer on the market. Tramadol is safe when taken at 50 mg every four - six hours along with ibuprofin to manage chronic pain. You can go as high as 100 mg. And sometimes I do on a really bad day. But I am not a drug abuser, I exercise reagularly even though I live with constant pain. I eat right and do everything I can to take care of my body. This drug has been a lifesaver for me. And as far as withdrawels, I can quit taking them for a week at a time and never experience any. I've done it just to ensure I am not becoming dependent on it. I belive those who have issues with the medication are abusers. If you read the posts of these people they are constantly mixing drugs they shouldn't and experimenting for the "high" not out of medical necessity. These are the people who are making drugs harder to get and causing regulations to get worse. I have to order online because I lost my job due to company bankruptcy and no longer have health insurance. Prior to this event, I have always been under a physicians care and the Tramadol is no problem when taken as prescribed. Great drug for those who live with chronic pain. Shadow
_________________________
Live For Today
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#642445 - 02/01/08 07:16 PM
Re: Ultram - Tramadol
[Re: Alyssa03]
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Veteran
Registered: 03/10/05
Posts: 560
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#643252 - 02/03/08 04:33 PM
Re: Ultram - Tramadol
[Re: Boocee]
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Journeyman
Registered: 12/27/07
Posts: 51
Loc: TX
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chloebaby, Did the doctor give you wellbutrin and tramadol together. The reason I ask is years ago my doc perscribed the two together and when I got them filled the pharm said they should never be taken together. No, I did not receive wellbutrin and Tramadol at the same time by the same doc. I received the wellbutrin from my psychiatrist, and the Tramadol from my family physician after somewhat of a "freak" accident with a door in a hotel in New Orleans. At the time when I first took Tramadol, I think I had little communication with the family doctor, so I probably didn't convey to him that I was on wellbutrin (my bad). But now that I think about it, I remember being concerned about any possible drug interactions - I was being prescribed a variety of medications for depression, rosacea, pain, intermittent infections. After some time, I did my own little research and discovered the seizure potential with both wellbutrin and Tramadol... it did make me more cautious. Anyway, enough rambling. Fortunately, I have never had a seizure. I was curious, however, whether anybody else had experienced the obnoxious stuttering that I mentioned.
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#643388 - 02/04/08 03:09 AM
Re: Ultram - Tramadol
[Re: nephro]
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Threadhead
Registered: 08/08/07
Posts: 804
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This has been discussed before in great detail; even Chemsynth got involved. We never reached a conclusion. Potentially there are interactions between Tramadol and SSRIs/SNRIs, but so many people are on these drugs, who also have pain, and there are so many doctors who want to give Tramadol instead of traditional opioids, that many patients have no choice. Also there are quite a few people on this board who take the 2 drugs together and don't experience problems. Bertinetti was commenting on clonazepam because it raises the seizure threshold. Serotonin syndrome is the main concern, and patients on these drugs ought to look out for the signs of this. Nephro, I've heard you mention Serotonin syndrome several times now, but I don't know what it is. Can you explain a little about what the effects are, what you feel, how to stop it, etc.? It just sounds like something horrible and it's a place I wouldn't want to be! Thanks1
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#748929 - 08/18/08 08:13 AM
Re: Ultram - Tramadol
[Re: dnj]
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Stranger
Registered: 03/14/06
Posts: 2
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Tramadol could work for migraines. Although, meds that are made to specifically target migraines would be more along the lines of what you need. I take Tramadol for joint pain. Tramadol has been a success story for me. I am unable to take stronger pain medications due to the fact that taking them nauseates me. Ultram is the name brand of Tramadol hydrochloride. Ultracet is simply Tramadol with tylenol. I would recommend the generic because it is exactly the same thing as the brand. I would probably stay clear of Ultracet because taking more tylenol than one needs is not necessary (IMO). I'm not a doctor, but I think that Tramadol is easier on the liver than OTC pain relievers.
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#748935 - 08/18/08 08:18 AM
Re: Ultram - Tramadol
[Re: dnj]
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Stranger
Registered: 03/14/06
Posts: 2
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Oh, I forgot, Tramadol is not classified as a narcotic, although it can cause euphoria. When I first started on Tramadol treatment, I noticed I felt a little "off". I think it all depends on ones metabolism, etc. Any side effects that I have had with Tramadol have been few and minor. I have had constipation on occasion, but the benefits of Tramadol outweigh any small quirks associated with taking the medicine. I hope you feel better and I hope that Tramadol works for you. It definitely has helped. Keep me posted!
Edited by kimmack1980 (08/18/08 08:20 AM)
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#749127 - 08/18/08 01:07 PM
Re: Ultram - Tramadol
[Re: nephro]
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Journeyman
Registered: 07/06/06
Posts: 52
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Wiki & read about Tramadol, its safety profile sort of sucks. Unlike the regular synthetic opioid pain relievers, it has more cancers associated with it and it more dangerous for pregnant mothers and can kill the newborn. The only problem with the oxy and hydro is the added Apap (Tylenol) and addiction potential with a social taboo of feeling nice. They have been around for a long time for good reason, and they are effective. Yup, It's common to feel a bit "off" when taking Trams since it messes with other brain neurotransmitters. Don't use it daily or you feel get the anxious need for more the next day & probably longer term health probs. If its all you got, go for it, just keep the rest in mind. Don't mix it with street drugs - wiki ODB's death.
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#749353 - 08/18/08 09:26 PM
Re: Ultram - Tramadol
[Re: amysue]
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Veteran
Registered: 04/18/06
Posts: 501
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don't mean to butt in here, but yes, amysue, you can take 2 50mg Tramadol at the same time. However, like nephro said, do not exceed 400 mgs a day. So you may want to space them six hours apart. You can take them every 4-6 hours. I find that taking 100mgs of Tramadol every 4-5 hours keeps the hydro withdrawals away and helps with the pain, sometimes better than the hydro, especially when you first start taking them. Let us know how they work for you. I am sorry you are going through this. Been there, done that and I feel bad for you - I really, really do!!! Take care, Sally
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#755137 - 08/28/08 07:47 AM
Re: Ultram - Tramadol
[Re: kimmack1980]
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Board Addict
Registered: 03/11/07
Posts: 378
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Tramadol could work for migraines. Although, meds that are made to specifically target migraines would be more along the lines of what you need. I take Tramadol for joint pain. Tramadol has been a success story for me. I am unable to take stronger pain medications due to the fact that taking them nauseates me. Ultram is the name brand of tramadol hydrochloride. Ultracet is simply tramadol with tylenol. I would recommend the generic because it is exactly the same thing as the brand. I would probably stay clear of Ultracet because taking more tylenol than one needs is not necessary (IMO). I'm not a doctor, but I think that tramadol is easier on the liver than OTC pain relievers. Thanks for the info. Traditional migraine meds don't work for me. I have a friend that gets 50 or more botox injections to her scalp -- all in one sitting -- because nothing works for her migraines, and even that is not working right now. I just can't go there. Anyway, I digress. I see that Tramadol cannot be taken with Wellbutrin and other antidepressants. Does that include Prozac? I take both. So if I need to take Tramadol but have already taken my anti D's that day, don't take it. But if I haven't taken them yet that day is it safe? Or do you have to be off them for a period of time before taking Tramadol? I will also ask PCP next time I see him but just wondered if anyone knows the answer to that question. Thanks!
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#755298 - 08/28/08 10:37 AM
Re: Ultram - Tramadol
[Re: dnj]
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Veteran
Registered: 02/28/08
Posts: 494
Loc: Southwest US
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Tramadol could work for migraines. Although, meds that are made to specifically target migraines would be more along the lines of what you need. I take Tramadol for joint pain. Tramadol has been a success story for me. I am unable to take stronger pain medications due to the fact that taking them nauseates me. Ultram is the name brand of tramadol hydrochloride. Ultracet is simply tramadol with tylenol. I would recommend the generic because it is exactly the same thing as the brand. I would probably stay clear of Ultracet because taking more tylenol than one needs is not necessary (IMO). I'm not a doctor, but I think that tramadol is easier on the liver than OTC pain relievers. Thanks for the info. Traditional migraine meds don't work for me. I have a friend that gets 50 or more botox injections to her scalp -- all in one sitting -- because nothing works for her migraines, and even that is not working right now. I just can't go there. Anyway, I digress. I see that Tramadol cannot be taken with Wellbutrin and other antidepressants. Does that include Prozac? I take both. So if I need to take Tramadol but have already taken my anti D's that day, don't take it. But if I haven't taken them yet that day is it safe? Or do you have to be off them for a period of time before taking Tramadol? I will also ask PCP next time I see him but just wondered if anyone knows the answer to that question. Thanks! If you are only taking 50 mg of Tramadol and 20 mg of Prozac, the chance of developing Serotonin Syndrome is small. It will reduce your seizure threashold, but that is only of concern if you have a history of seizures. I take Tramadol for CTS, and only on occassion, but it makes any headache that I have worse! I think this is due to it's affinity for norepinephrine, which is stimulating and can case a tension headache to get worse. I also wouldn't take it too close to bed time for this reason.
Edited by jehza1 (08/28/08 10:43 AM)
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#768288 - 09/18/08 05:02 PM
Re: Ultram - Tramadol
[Re: nephro]
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Old Hand
Registered: 08/01/08
Posts: 394
Loc: UK
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The parenteral route allows for greater daily doses than does PO; does this mean that SL, buccal and PR total daily doses can be higher in the same proportion? Some here know my medical history so im not going to go through it again in full, quick summary though, I had avascular necrosis in my hips, had bilateral coredecompression, left sorted, no problems, right still giving problems. Have been on Trams daily since last year Novemberish. I know about the 400 mg rule but hand on heart have taken up to 16 50mg in a day at times along with quite a few co-codomols and have never had any noticeable probs. (this was purely to get through work, I dont find they give me any sort of high, never have) I have been much better but had to do a lot of running around during my sons birth this week (had my op about 12 weeks ago) so had a flare up of pain, I took quite a few trams yesterday and today and have had the usual persistent problem I have when taking too many, problem urinating, I am also having kidney pains on the left side. I really want to try something different but the docs will just not prescribe me anything else, and thats after changing docs twice!! I also take Valium/Xanax (depending on the day) and Modalert and ephedrine when working nights. Is there anything that will be less damaging and more effective for the pain when it does flare up. I am in all honesty battling to get off the Trams now, I find I get sweats and irritabillity so take one or two a day on the good days, its getting ridiculous. Ive tried Bupe 0.2 x 2 and they seem to work, would these be any less damaging or difficult to get off while I work through the last stage of this problem. Im also worried about my liver and kidneys, I gave up drinking and smoking in March so obviously that has helped, any suggestions on something to help protect the liver and kidney, and most of all the urination problems, is that something to worry about long term, it really causes me concern. Any advice would be greatly appreciated. Originally Posted By: ProAnthGonz
No, the pain relief will not increase. Tramadol works also as an SNRI (Effexor is a pure SNRI) but Tramadol also works by mocking how true opiates bind to the Mu rector. So just be careful with the SNRI action and properties it has. I personally have about 4 years of experience and daily taking of Tramadol, I know everything there is know from learning, research, and most of all personal experiences. If anyone has any further questions feel free to ask, there is a lot of rumors and invalid myths and info going around about Tramadol.
Edited by daddyd (09/18/08 05:05 PM)
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You Have Nothing To Fear But Fear Itself..
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#768291 - 09/18/08 05:10 PM
Re: Ultram - Tramadol
[Re: daddyd]
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Old Hand
Registered: 08/01/08
Posts: 394
Loc: UK
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The parenteral route allows for greater daily doses than does PO; does this mean that SL, buccal and PR total daily doses can be higher in the same proportion? Some here know my medical history so im not going to go through it again in full, quick summary though, I had avascular necrosis in my hips, had bilateral coredecompression, left sorted, no problems, right still giving problems. Have been on Trams daily since last year Novemberish. I know about the 400 mg rule but hand on heart have taken up to 16 50mg in a day at times along with quite a few co-codomols and have never had any noticeable probs. (this was purely to get through work, I dont find they give me any sort of high, never have) I have been much better but had to do a lot of running around during my sons birth this week (had my op about 12 weeks ago) so had a flare up of pain, I took quite a few trams yesterday and today and have had the usual persistent problem I have when taking too many, problem urinating, I am also having kidney pains on the left side. I really want to try something different but the docs will just not prescribe me anything else, and thats after changing docs twice!! I also take Valium/Xanax (depending on the day) and Modalert and ephedrine when working nights. Is there anything that will be less damaging and more effective for the pain when it does flare up. I am in all honesty battling to get off the Trams now, I find I get sweats and irritabillity so take one or two a day on the good days, its getting ridiculous. Ive tried Bupe 0.2 x 2 and they seem to work, would these be any less damaging or difficult to get off while I work through the last stage of this problem. Im also worried about my liver and kidneys, I gave up drinking and smoking in March so obviously that has helped, any suggestions on something to help protect the liver and kidney, and most of all the urination problems, is that something to worry about long term, it really causes me concern. Any advice would be greatly appreciated. Originally Posted By: ProAnthGonz
No, the pain relief will not increase. Tramadol works also as an SNRI (Effexor is a pure SNRI) but Tramadol also works by mocking how true opiates bind to the Mu rector. So just be careful with the SNRI action and properties it has. I personally have about 4 years of experience and daily taking of Tramadol, I know everything there is know from learning, research, and most of all personal experiences. If anyone has any further questions feel free to ask, there is a lot of rumors and invalid myths and info going around about Tramadol. If you happen to see this post and have any input, please pm me to let me know you've left a response as I might miss it. With a new baby in the house it is crazy and I havnt been able to get on the computer as often as I would like... many thx..
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You Have Nothing To Fear But Fear Itself..
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#879165 - 04/22/09 03:24 PM
Re: Ultram - Tramadol
[Re: SoHoTribeca]
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Member
Registered: 09/27/06
Posts: 198
Loc: Arizona
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I have tried Tramadol and do take SSRI's as well. Have talked with various pharmacists and doctors and as long as you keep your Tramadol use moderate and short term, Serotonin Syndrome is no worry at all. I find that Tramadol does not work on pain as well as the opiates, but does sort of make me feel good. I have had some skin irritations, but do not know if Tramadol had anything to do with it. Have anyone had an issue with skin rash/irritation/itching?Thanks, Jeff
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#917109 - 08/11/09 07:54 PM
Re: Ultram - Tramadol
[Re: nephro]
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Threadhead
Registered: 11/07/05
Posts: 923
Loc: MA
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couple of things: 1. seizures are an adverse effect of Tramadol, but they are not serotonergic in origin. they have a totally different cause/treatment 2. serotonin is one of teh neurotransmitters that is responsible for regulating movement: too much serotonin can lead to too much movement. a common finding in someone with serotonin syndrome is tremor/thumping in legs more so than arms, increased muscle tone/rigidity. 3. serotonin is one of the neurotransmitters that controls behavior. too much serotonin, too much....of you. patients are "hypomanic', meaning that they are a bit too loud, move to fast, a bit uncontrollable, etc, etc. 4. symptoms of serotonin syndrome arise within 24 or less (usually much less, like 6 hours) of starting a new medication. the reality is that many people respond to these medications differently, so anyone who has any concerns should see their doctor or go to an ER. and, just for nephro--no demerol!! hope this helps, chemsynth
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#917114 - 08/11/09 08:12 PM
Re: Ultram - Tramadol
[Re: chemsynth]
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Enthusiast
Registered: 06/07/07
Posts: 269
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couple of things: 1. seizures are an adverse effect of Tramadol, but they are not serotonergic in origin. they have a totally different cause/treatment 2. serotonin is one of teh neurotransmitters that is responsible for regulating movement: too much serotonin can lead to too much movement. a common finding in someone with serotonin syndrome is tremor/thumping in legs more so than arms, increased muscle tone/rigidity. 3. serotonin is one of the neurotransmitters that controls behavior. too much serotonin, too much....of you. patients are "hypomanic', meaning that they are a bit too loud, move to fast, a bit uncontrollable, etc, etc. 4. symptoms of serotonin syndrome arise within 24 or less (usually much less, like 6 hours) of starting a new medication. the reality is that many people respond to these medications differently, so anyone who has any concerns should see their doctor or go to an ER. and, just for nephro--no demerol!! hope this helps, chemsynth Thanks Chem. I think I am probably fine, based on your above info. I was the OP that asked Nephro about SS Are there any long term effects linked to excessive or high levels of serotonin; levels that would be provided by the dosages and medications described in my previous posts?
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#930776 - 09/16/09 08:32 PM
Re: Ultram - Tramadol
[Re: sonik]
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Administrator
GRAND Pooh-Bah
Registered: 11/18/01
Posts: 6370
Loc: DrugBuyers.Com
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From Wikipedia http://en.wikipedia.org/wiki/Tramadol Grünenthal, which still owns the patent to Tramadol, has cross-licensed the agent to pharmaceutical companies internationally. Thus, Tramadol is marketed under many trade names around the world, including: Acugesic (in Malaysia and Singapore) Adolonta (in Spain) Algifeno (in Bolivia) Anadol (in Bangladesh and Thailand) Boldol (in Bosnia and Herzegovina) Calmador (in Argentina) Campex (in Pakistan) Contramal (in India, Italy, and Turkey) Crispin Dolcet (in the Philippines) Dolol (in Denmark) Dolzam (in Belgium and Luxembourg) Dromadol (in the United Kingdom) Exopen (in South Korea) Ixprim (in France and Ireland) Lumidol (in Bosnia and Herzegowina and Croatia) Mabron (in Bahrain, Bangladesh, Bulgaria, Czech Republic, Estonia, Iraq, Jordan, Latvia, Lithuania, Malaysia, Oman, Romania, Singapore, Slovakia, Sri Lanka, Sudan, and Yemen) Mandolgin (in Denmark) Mandolgine Mosepan Matrix (combined with paracetamol) (in Honduras and Guatemala) Nobligan (in Argentina, Denmark, Iceland, Mexico, Norway, Portugal, and Sweden) Osteodol (in India) Poltram (in Poland) Ralivia (in Canada) Ryzolt (in the United States) Sintradon (in Serbia) Siverol (in the Philippines) Tandol (in South Korea) Tiparol (in Sweden) Tonoflex (in Pakistan) Toplagic Tradol (in Bangladesh, Ireland, Mexico, Singapore, and Venezuela) Tradolan (in Austria, Denmark, Finland, Iceland, Romania, and Sweden) Tradonal (in Belgium, Indonesia, Italy, Luxembourg, the Netherlands, the Philippines, Spain, and Switzerland) Tralgit (in the Czech Republic, Georgia, Romania, and Slovakia) Tralodie (in Italy) Tramacet (combined with paracetamol) (in Canada and Costa Rica) Tramacip (in India) Tramadex (in Israel) Tramadin (in Finland) Tramadol (in Chile and Romania) Tramadol Stada (in Sweden) Tramadolor (in Austria, Estonia, Germany, Hungary, Latvia, Lithuania, Luxembourg, and Romania) Tramagetic (in Norway) Tramagit (in Romania) Tramahexal (in Australia) Tramake (in the United Kingdom) Trama-Klosidol (in Argentina) Tramal (in the Netherlands, Finland, Croatia, Slovenia, Brazil, Chile, Romania, Australia, New Zealand, Germany, and Switzerland) Tramalgic (in Hungary) Tramal Gotas (in Ecuador) Tramazac (in India, Myanmar, and Sri Lanka) Tramed Tramedo (in Australia) Tramoda (in Thailand) Tramundal (in Austria) Tridol (in South Korea) Tridural (in Canada) Trodon (in Serbia) Ultracet (combined with paracetamol) Ultradol Ultram and Ultram ER (in the United States) Ultramed (combined with paracetamol) (in India) Veldrol (in Mexico) Zafin (combined with paracetamol) (in Chile) Zaldiar (combined with paracetamol) (in Spain, Croatia, Poland, Russia, and Chile) Zaledor (combined with paracetamol) (in Chile) Zamadol (in the United Kingdom) Zamudol (in France) Zodol (in Chile, Ecuador, and Peru) Zydol (in the United Kingdom, Ireland and Australia) Zytram (in Canada, Iceland, New Zealand, and Spain) Zytrim (in Spain)
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If you have tried both at one time or another...what about sleep? Did either one let you do that better than the other?? I miss sleep... 
Great.
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