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#84972 - 04/12/07 11:43 AM
Re: Ultram - Tramadol
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Enthusiast
Registered: 04/19/06
Posts: 218
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I have heard, and can personally verify, that Tramadol sort of "offsets" the effects of Hydrocodone because it works on the same receptors. If this is true, then I would guess it would also be true for Tylenol 3. So, you might be "negating" the effects of your T3, not extending them. I am not a Doctor, I don't play one on TV and at DB.com I am only spewing forth my opinions, repeating rumors and hearsay. So, do not ever say, "Well, Swizzelstick says....", because most likely I probably "made up" whatever it is you might repeat.  ~ Swizzel
_________________________
Remembering that Keith Richards is still alive makes me breath a sigh of relief.
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#84976 - 05/29/07 12:39 PM
Re: Ultram - Tramadol
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Threadhead
Registered: 12/01/05
Posts: 732
Loc: United States
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Quote:
I have heard, and can personally verify, that Tramadol sort of "offsets" the effects of Hydrocodone because it works on the same receptors.
If this is true, then I would guess it would also be true for Tylenol 3. So, you might be "negating" the effects of your T3, not extending them.
I am not a Doctor, I don't play one on TV and at DB.com I am only spewing forth my opinions, repeating rumors and hearsay.
So, do not ever say, "Well, Swizzelstick says....", because most likely I probably "made up" whatever it is you might repeat. 
~ Swizzel
Swizzel,
You are indeed correct, it is not just anecdotal or your opinion but fact. It is posted on WebMD and in the PDR.
Ultram (Tramadol Hcl), and Ultracet (Tramadol with apap) binds with mu1 and tends to block mu2 to a lesser degree with no kappa binding at all. Most opiods bind with mu1 and mu2 primarily and some with mu1, mu2 and kappa1. So if you take Ultram and a true opiod, the Ultram and the other opiod are both competing for the same receptors in the brain. The only thing we don't know for sure is which one is going to win out in the competition!!!!
Frankly, most of the docs I know don't recommend using Ultram with other opiods. You can safely take it with NSAIDS like Aleve or Motrin though. Remember a couple of things that are different with Ultram as opposed to other pain relievers..... Ultram does indeed have some mild to moderate SSRI properties, so if someone is on an SSRI for depression, OCD etc. like Prozac, Paxil, Luvox and the like, one could develop serotonin syndrome which is uncomfortable. That is too much build up of serotonin in the synaptic spaces.
There is one other problem you must keep in mind with Ultram, please watch your dosage. If Ultram is taken in too high a dose it lowers the seizure threshold and you could wind up having convulsions.
A very good ER doc I know wound up with an addiction to opiates. He is clean and sober over 3 years now, but he did have a bad problem. He tried to detox himself from percocet and hydromorphone using Ultram. He took very high doses, over 300mg per dose several times a day. He wound up having a full generalized motor seizure in the middle of the emergency department floor.
Thank goodness he entered an inpatient program for impaired physicians in the Atlanta Ga. area and is doing great now, but just a bit of a cautionary tale.
_________________________
"They who would give up an essential liberty for temporary security, deserve neither liberty or security," Benjamin Franklin
I am not a Real Doctor but I play one on DB
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#84977 - 06/11/07 07:58 AM
I know this drug and these are facts
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Newbie
Registered: 06/11/04
Posts: 40
Loc: a nice place to live
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Hi. I have been taking Tramadol for about three years steadily. I have had low doses and given myself very high doses. With this in mind, just realize that every person's body reacts differently to a medication. I never had a seizure no matter how many I took. Constipation, on the other hand, was awful. Never had that before this med. 1. This med is a mild pain reliever and never realy worked well for the pain. However, for depression, it is terrific (things that doctors do not know... remember, most M.D.'s are stupid and only have that degree because their family was wealthy... they do not even try what they prescribe). That said, Tramadol ( Ultram) has a mild opiate effect and also has a mild antidepressant effect as it provides a bit of norepinephine and serotonin reuptake. The result is that this pill is a great well-being pill. No need for antidepressants along with it for that is a bad combination. I also do not drink much... but I would say that alcohol might up the seizure potential. BE CAREFUL WITH THIS AND ALCOHOl. 2. Now, the tendency is to continue to take more in order to get the same effect. It is in this way that it is addictive and will be a controlled substance ala the narcotics soon. Docs are waking up to the fact that the pill is waay addictive with awful withdrawals if you go cold turkey. Clients are calling in and reporting trouble coming off. I know. I was taking 30 to 40 a day with no problem but cost and waking up the next morning feeling depressed. Additionally, it does cause constipation and prolongs the sexual ability to ejaculate (could be a godsend to some; but I found that at large dosages, I was having a hard time keeping erections or even having them... of course, you will not read that anywhere... but it is true). So, the med is not perfect, but it really helps the mood and is further elevated by 420. 3. Withdrawal is a pain in the behind. No different from any narcotic and they even prescribe methadone-like drugs (suboxone) to help you get off the [censored] thing. I remember once when I was almost out of this med and had been taking a lot and boy those were tough withdrawals. I woke up in the middle of the night and it felt like my entire nervous system was on fire. Two pills and it was gone. But BE CAREFUL please!! This little pill is nothing to fool with and you do not want the withdrawals. At a low dose, it might even begin to bother you as it pushes you for more. Yet, the low dose withdrawal is not bad if you have something to wean you off like a benzo or another opiate. 4. It does affect sleep. Very odd is this. It puts you in a "reverie"... a dreamlike state between waking and sleeping. Actually, it is pleasant experience and I never worried about going to sleep. 5. Finally, I loved taking this drug as it promoted my enjoying this life more and I was very functional. One does not feel much different than normal but much happier. I could do anything... drive, write, speak... no sweat. Yet, there comes a time when the money outlay is considerable and the addiction FACT has hit home and, at that point, you are traversing a chasm you might not want to cross. AND there is resultant depression the next day until you take some (which could be as much as 12 at a time even though the dosage is recommended to be no more than 8 a day). It makes me wonder why the medical community and the government are allowing this when they must know the effects of the med. It will not wipe you out like cocaine or heroin, but it can wreak havoc if you use too much. I like it. It is a good drug as an antidepressant and very mild pain reliever. However, I do not know if I can afford the cost and the withdrawals to continue. Currently, I am off and I do miss it. My life has not been an easy one and it is great to find something that promotes some well-being in the midst of this world that has gone nuts. What happened to freedom around this world? You work your buns off to get from paycheck to paycheck and the alcohol/cigarettes thing is a legal poisoning. Man.... I am not surprised that anyone would seek some relief from these gas prices and the constant lies by the government. So, Tramadol can be a substance that is calming. I liked to have it with a benzo so that the feeling is really controlled. Yet, it has its downfalls like all things foreign to the body. So, be careful and take care of yourself. This thing can sneak up on you and you will find that it becomes a part of your life.
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