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#831000 - 01/17/09 03:13 PM do antidepressants really work?
lazyscience Offline
Newbie

Registered: 11/19/08
Posts: 34
do you think antidepressants really work? i mean, theres no evidence that they perform any better than a placebo. they certainly didnt work for me.

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#831011 - 01/17/09 03:34 PM Re: do antidepressants really work? [Re: lazyscience]
bdit Offline
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Registered: 02/23/07
Posts: 956
Loc: Mid South
I think it depends on your situation and which antidepressant you take.

A few years ago I was nervous about my first overseas flight (hate flying), and my father was dying of cancer. My doctor prescribed Zoloft and told me it would take about 2 weeks before it started working. It definitely worked. I took a high dose, and got to where nothing much at all bothered me. I took it for a year, and then stopped taking it when all the bad things in my life went away. It really did help me get through some rough times.

Everybody's different. I know people who don't do well on Zoloft, but it was a lifesaver for me.

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#831020 - 01/17/09 03:44 PM Re: do antidepressants really work? [Re: bdit]
lazyscience Offline
Newbie

Registered: 11/19/08
Posts: 34
dont you think though that it will only work if you believe that its going to work? like when i first started to take antidepressants i though, hmm maybe i feel a bit better, then i started to read the drug trials and realised theres no evidence that they work. after that i never felt that any antidepressant made even the remotest bit of difference to the way i feel. just horrible side effects. also, maybe they are just a way for the big drug companies to make an absolute fortune. take this drug, take that drug, just keep trying them until you get one that works. they must shift tons of those drugs.

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#831211 - 01/18/09 03:49 AM Re: do antidepressants really work? [Re: lazyscience]
genethebean1 Offline
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Registered: 01/08/07
Posts: 3315
Loc: The Boonies
I do believe they work - at least to some degree. The first one I took was prozac. The initial dose was too high and I was very agitated and anxious. When I decided to try it again, I went to a Psyciatric Nurse Practitioner. She had me titrate very slowly up to a therapeutic dose. It took about 8 weeks before I felt better but I actually felt worse starting about week six (extreme fatigue). Then one day, I realized that I was feeling great. Unfortunately, it only worked for about a year (and I gained a fair amount of weight).
_________________________
The true triumph of reason is that it enables us to get along with those who do not possess it - Voltaire

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#831271 - 01/18/09 07:01 AM Re: do antidepressants really work? [Re: lazyscience]
dawn147 Offline
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Registered: 05/08/07
Posts: 1546
Loc: somewhere in time
 Originally Posted By: lazyscience
do you think antidepressants really work? i mean, theres no evidence that they perform any better than a placebo. they certainly didnt work for me.
I will second that....
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The most difficult thing to do is to do nothing at all

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#831404 - 01/18/09 01:05 PM Re: do antidepressants really work? [Re: dawn147]
eluded Offline
Pooh-Bah

Registered: 06/29/08
Posts: 1285
the right drug WILL work on the right person. no single drug is effective for the entire population due to the various differences in genitics and brain chemistry that changes in each person throughout their lives. prozac may work for someone when they are 30 but not later when they are 50 because their brain chemistry has changed with the aging process. that is why there are dozens of drugs for the MD to choose from. they all try to be broad spectrum so they can work for everyone, but thats just impossible since everyone is so chemically different. the right drug will work if fitted to the right patient.

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#835279 - 01/26/09 02:21 PM Re: do antidepressants really work? [Re: eluded]
toddz Offline
Member

Registered: 02/17/08
Posts: 113
i find it funny the drug companies will say our med worked x times better than a sugar pill, some triumph for medical science.

studies claim antidepressants are effective on about 40 percent of the pple, some doubt its that high. some pple do find relief at least to some degree, some search for yrs for the right combination. the docs make assumptions, like everyone that walks through their doors that suffers from depression has a chemical imbalance, when really they have no idea of that for certain. the shrinks ive had werent interested in helping me find the right med or combo, but were just in a hurry to hear the story and write a script.

everyone is different, some pple have not found relief from any antidepressant. im one of them. as far as what the docs do in prescribing a certain med, they might as well go into their office, shut the door and throw a dart at a board with all the meds listed. the doc has no idea whether it will be effective on the patient, its all a [censored] shoot, an expensive one. and at the end of the day most of these meds leave ya more tired with no energy and still the beast of depression remains.

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#835340 - 01/26/09 03:53 PM Re: do antidepressants really work? [Re: toddz]
Sio Offline
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Registered: 08/11/04
Posts: 552
Loc: Atlanta, GA
They do all work, but not necessarily for you. It is a trial and error thing and kind of frustrating because it takes a long time to gauge it. My first experience with an antidepressant was with my dog. This was back when Prozac was the only one available and they weren't even using it on dogs. After a false pregnancy my pooch turned into a demon dog. She would be fine one minute cuddling with her sister and then bam - suddenly she would attack my other dog usually while she was sleeping. It was vicious and often the bites would draw blood. It was bad. I tried training, school, separating, keeping her on a leash always and a few trips to my vet. She was very involved with her alma mater Cornell Vet School that was studying the effects so we decided to give it a try. It was very expensive ($150 a bottle) and when I saw no effect at 5 weeks I figured I wouldn't renew the script when I ran out. Suddenly 2 days after I was ready to give up it kicked in and worked. She turned back into my loving playful sweet girl. She wouldn't know to believe it was going to work or not so it couldn't be mind over matter.

A few years later I tried Zoloft. It made me sooo btchy that my family begged me to stop which I did.

Then a couple years later I heard people on Wellbutrin were having a side effect of losing weight so I asked my Dr to give it a shot. She said it's not for weight loss but would have no objection with me taking it. I don't remember consciously realizing if it was working or not but when I lost my health insurance I just couldn't afford it so I weaned off. I began to reevaluate my life recently and realized I functioned at such a higher level when I was on it - so I just started it again. I know it takes weeks to know but it does give me a little more energy and certainly am even on it so I am looking forward to getting back to that high functioning place again.

I think men have more negative issues than women do with antidepressants. It can effect them sexually so most men I know would rather be in a dark depression with an erection than emotionally even without! Guys I know have done more trial and error than I have had to.

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#835363 - 01/26/09 04:39 PM Re: do antidepressants really work? [Re: Sio]
4lori Offline
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Registered: 10/08/06
Posts: 263
 Originally Posted By: Sio
...Then a couple years later I heard people on Wellbutrin were having a side effect of losing weight so I asked my Dr to give it a shot...


Did you lose weight?

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#835517 - 01/27/09 12:15 AM Re: do antidepressants really work? [Re: 4lori]
Sio Offline
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Registered: 08/11/04
Posts: 552
Loc: Atlanta, GA
I did! Actually about 45 pounds but don't know if I can credit the wellbutrin. I think it was a hormonal change because my hair texture really changed, actually got thicker and pin straight. Both are great changes and am in my 40s so I am attributing it more to perimenopause. God's giving me a years before I dry out and shrivel up for menopause.


Edited by Sio (01/27/09 12:16 AM)

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#835701 - 01/27/09 11:41 AM Re: do antidepressants really work? [Re: Sio]
toddz Offline
Member

Registered: 02/17/08
Posts: 113
they work at least to some degree, on some pple. certainly not everyone finds comfort and relief from antidepressants. thats why the estimates of their success remains at 40 percent. if they really worked so well the overall success rate of antidepressants would be much higher. many pple still have a terrible struggle, though on antidepressants.

of course men would opt for not taking a med that will create yet another problem for them to deal with. but if i had to choose, id prefer to not be depressed than "be in a dark depression with an erection than emotionally even without".

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#836108 - 01/27/09 11:04 PM Re: do antidepressants really work? [Re: toddz]
Code21 Offline
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Registered: 07/05/07
Posts: 649
Loc: K-Pin Highway
Hell yeah they work. They saved my life and let me live my life as the person I really am. Depression was a horrible monster that kept me locked up in a cage.
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Ahh Klonopin, sweet nectar of the gods!

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#836122 - 01/27/09 11:48 PM Re: do antidepressants really work? [Re: lazyscience]
JokerOwling Offline
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Registered: 07/14/07
Posts: 1770
Loc: here at the moment
 Originally Posted By: lazyscience
do you think antidepressants really work?
No.Some people BELIEVE they do though.So if their BELIEF makes them feel better,then I suppose anti-depressants SEEM to work for some people.
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#836149 - 01/28/09 03:25 AM Re: do antidepressants really work? [Re: JokerOwling]
sarahte Offline
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Registered: 09/04/08
Posts: 732
Loc: MidWest
Of course some types* of aniti-s work, for some problems.
(Mine was prescribed for pain along with depression associated with chronic pain)

Question is, are you willing to be a guinea pig for a few years until they find the right *family, *type *dosage for YOU?

That was my deal,.. about 4 years of trial /error. I stopped and and dealing with other* alternatives.
I like it better this way, I KNOW whats going into my body and brain. Heck, 2 - 3 times a week at the gym therapy pool
does a lot more than any of the aniti-s ever did,
but, thats just my story.
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#836216 - 01/28/09 08:08 AM Re: do antidepressants really work? [Re: sarahte]
moira Offline
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Registered: 06/12/07
Posts: 550
Loc: U.S.A.
 Originally Posted By: sarahte
Of course some types* of aniti-s work, for some problems.
(Mine was prescribed for pain along with depression associated with chronic pain)

Question is, are you willing to be a guinea pig for a few years until they find the right *family, *type *dosage for YOU?

That was my deal,.. about 4 years of trial /error. I stopped and and dealing with other* alternatives.
I like it better this way, I KNOW whats going into my body and brain. Heck, 2 - 3 times a week at the gym therapy pool
does a lot more than any of the aniti-s ever did,
but, thats just my story.


couldn't have said it better myself. That is just what happened in my case...I told my doctor he could try all those freaking pills until he got it right and to let me know how he felt. I just got tired of being his GUINEA PIG. They don't have a clue either, they just read what has had the best feedback and assume it will work for everyone. Then have you ever noticed when a new med comes out, they jam it down your throat? I wonder what kind of kickbacks these doctors get?

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#836226 - 01/28/09 08:21 AM Re: do antidepressants really work? [Re: moira]
Sio Offline
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Registered: 08/11/04
Posts: 552
Loc: Atlanta, GA
I heard recently they just outlawed those kickbacks. Done are the pens, books, clipboards and checks to Docs - but I don't believe it. The Pharmaceutical companies will find other ways to reward the Docs - they always do and truthfully while some Docs are making millions I think the vast majority are living a middle to upper middle class salary which ridiculous hours, insane malpractice insurance and student loans most of us couldn't imagine. If my Doc can get a perk here or there I hope she takes advantage of it. She deserves it.

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#836287 - 01/28/09 10:22 AM Re: do antidepressants really work? [Re: Sio]
ww2w Offline
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Registered: 01/24/09
Posts: 30
Paroxetine is very popular in europe. But for beginners I recommend Fluoxetine (prozac) because it is the weakest of all the SSRI's, and it have also the longest half-life time. Now i'm looking for a good shop where I can find medication like Paroxetine (paxil), and Fluoxetine(prozac).

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#836406 - 01/28/09 02:08 PM Re: do antidepressants really work? [Re: lazyscience]
pillar Offline
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Registered: 11/07/06
Posts: 1908
Loc: The Doors of Perception
I haven't found one yet that works, but I've found a site that offers some hope, for those of us that are struggling to pay for treatment that works.

http://www.clinicalconnection.com/searchstudies.aspx

I posted a thread in the 'Other meds and medical conditions' forum, if you want a little more info. Since I'm using them to find help with my depression I thought I'd post it over here, as well. Desipramine, Nortriptyline, Amitiptylene, Trazodone, Lexapro, Paxil, Prozac, Cymbalta, EffexorXR, Pristiq, Symbyax, Seroquel, Gabapentin, Ativan, and Klonopin have all failed me so far. It's discouraging but I'm still hanging in there.
_________________________
"God deliver us from such criminal imbecility."

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#838652 - 01/31/09 08:14 PM Re: do antidepressants really work? [Re: pillar]
toddz Offline
Member

Registered: 02/17/08
Posts: 113
thanks pillar. yes its very discouraging.

code21, glad they helped you, as i said they help some pple.

silo, most established docs dont have the burden of medical school on their heads. some that agree to work in left overshoe, wy, or someplace similar, get at least part of their school paid for by signing on for a cetain time, plus a decent salary.

perks? to be dished out meds because it benefits the docs pocket, and not because it is the best med for the patient... is wrong. pens fine, give em pens. there are no poor doctors. ive never known a doc that was making middle class wages. lets all have a pity party for these poor overworked healers.

there are a few that truly have a compassionate bone in their bodies, let alone doing good in the world. doctors without borders, is the exception.

i was a healthcare administrator, i know alot about docs.


Edited by toddz (01/31/09 08:29 PM)

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#838667 - 01/31/09 08:42 PM Re: do antidepressants really work? [Re: toddz]
Faith2005 Offline
Board Addict

Registered: 04/30/07
Posts: 371
Hi everyone.. just noticed this topic and would like to help by saying i was on sarafem (form of prozac) for my pmdd ,, (womans intense pms problem with mood swings, depression, pain, etc),, it really did help me but made me a little loopy ,,, I would stare at the sky and get all---wow look at the pretty clouds,look at the pretty trees--- look at the pretty man peeing on the corner of 14th street on the wall...lol ,,, i cut the dose and felt alot less spaced out ,,, i had stoped using the prozac about a 2yrs ago as i was afraid to mix pain meds and them together but have been needing to go back on them .. they did help me but i personally dont want to rely on them .. take care everyone sincerely Faith


Edited by Faith2005 (01/31/09 08:42 PM)
Edit Reason: spelling booboo

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#838971 - 02/01/09 01:14 PM Re: do antidepressants really work? [Re: lazyscience]
70727487 Offline
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Registered: 07/04/07
Posts: 929
Loc: Great Patriot Awakening

I feel they do help. But sometimes a patient may not respond to the first antidepressant prescribed. It is very important to find the right one for you, and not to give up if the first one tried did not produce results. Also it's very important to communicate with your physician if you feel they are not working. Not all antidepressants produce the same effects in all patients.
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A Change Is Gonna Come Yes it is

http://www.youtube.com/watch?v=yvayzIktT...PL&index=20

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#838982 - 02/01/09 01:38 PM Re: do antidepressants really work? [Re: 70727487]
dpalmento Offline
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Registered: 02/07/08
Posts: 59
I have been on 4 different antidepressants in the past and they did not work. My doctor was giving to me for my back pain and to help me sleep. They were very hard to stop taking though, but I got off them. The last was effexor--brain zaps and strange feelings when I turned my head-- but tapered off them and those feelings went away.

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#838987 - 02/01/09 01:49 PM Re: do antidepressants really work? [Re: 70727487]
toddz Offline
Member

Registered: 02/17/08
Posts: 113
if you have had to go through the frustration of new meds time and time again without positive results, waiting for the benefits and trying to cope with the side effects, you might take a more cynical view of antidepressants, as i do. many pple do struggle literally yrs trying to find the best combination, and go through several doctors as well. some do hit a combo that works, many others never do, and struggle with finding some relief before its to late.

ive yet to find a doc that really was concerned or cared for that fact. to them, its like...well lets try this one next. big deal they arent coping with major depression symptoms.

as i said, they help some pple and many others are left meds that provide them little or no relief. i hope in the future there will be some alternatives to the antidepressants we have available now.

quoting g.w. bush...now that made me laugh.

"I'm telling you there's an enemy that would like to attack America, Americans, again. There just is. That's the reality of the world. And I wish him all the very best." --George W. Bush, Washington, D.C., Jan. 12, 2009

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#838999 - 02/01/09 02:14 PM Re: do antidepressants really work? [Re: toddz]
70727487 Offline
Threadhead

Registered: 07/04/07
Posts: 929
Loc: Great Patriot Awakening

Toddz, I understand how frustrated you must feel and I am so sorry medication wasn't effective on your depression. You know sometimes I feel a Psychiatrist, may have a better understanding and be more sensitive to patients experiencing mental or emotional problems. Thats just me not all people feel this way. Sometimes support groups can help also.

Well, I am glad my Bush quote didn't make you more depressed , then I would have felt really bad.

I hope someday you are free of your depression, I do understand how debilitating it can be , as I have experienced depression as well. If you are ever really down and need someone to talk to I am here.
_________________________
A Change Is Gonna Come Yes it is

http://www.youtube.com/watch?v=yvayzIktT...PL&index=20

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#839012 - 02/01/09 02:49 PM Re: do antidepressants really work? [Re: 70727487]
Sio Offline
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Registered: 08/11/04
Posts: 552
Loc: Atlanta, GA
I think the problem is alot of times the shrinks overmedicate and zone out people so they become numb. I know someone right now on a combo of 5 and she is just a shell of the person I used to know. I think an outside objective perspective is really important to help determine if the med is working.

I know when I was on antidepressants before I would say they did nothing for me. After about 18 months I weaned off them and a year later re-evaluated my life...when were things better - when was I more successful, less pain, less stress and I realized the previous year was a lot better - and I just functioned better. I don't really know for certain if it was just circumstance or the med but I decided to go back on it to see. I know it takes a long time to see a change but once the first weeks are over I have no negative side effects so why not. My Dr said people never think antidepressants are working until they are off them for awhile. You may think they are a waste of time but it takes awhile to see result. If the side effects continue after a few weeks - yes, a change is needed but otherwise you wont be able to tell much for a few months in my experience.

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#839016 - 02/01/09 02:55 PM Re: do antidepressants really work? [Re: Sio]
70727487 Offline
Threadhead

Registered: 07/04/07
Posts: 929
Loc: Great Patriot Awakening


Well, there are good ones and bad ones Sio. If your friend is experiencing a dramatic change as you have described and I was a family member I would be very concerned. And be confronting him( with the patients permission of course) or searching for a different physcian.
_________________________
A Change Is Gonna Come Yes it is

http://www.youtube.com/watch?v=yvayzIktT...PL&index=20

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#842115 - 02/08/09 07:05 PM Re: do antidepressants really work? [Re: 70727487]
appleorange Offline
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Member

Registered: 05/26/08
Posts: 157
MAOI's are another anti-depressant you will probably never hear about. Most modern doctors do not even know what they are.

They were some of the first anti-depressants ever created and to this day still remain the most powerful. When SSRI's like Prozac came out, MAOI's became forgotten about in medical literature. This was mainly due to MAOI's having a lot of dietary restrictions and adverse side effects where as Prozac had very few side effects in comparison.

SSRI's are completely bunk. They do not work, they are just a sugar pill that makes your thing malfunction.

There are two effective MAOI's in existence:

1. Nardil
2. Parnate

Nardil is the most effective and even has the added benefit of generating gaba within your brain. Gaba is what controls or inhibits anxiety. So not only is Nardil prescribed as an anti-depressant, but also a Social Anxiety drug as well.

Parnate on one hand acts very differently, it converts to amphetamine within your body and raises dopamine to very high levels. Doctors always have to prescribe a sleep-aid like ambien alongside it because it will have you wired all day long.



The best prescription for combating depression is 75-90mg of Nardil daily + 1 or 2mg of Klonopin daily.


-Peace








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#842159 - 02/08/09 10:39 PM Re: do antidepressants really work? [Re: appleorange]
nephro Offline
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Loc: NOT 40!
They are very effective but I'd leave out the clonazepam, as it can worsen depression.

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#842210 - 02/09/09 04:56 AM Re: do antidepressants really work? [Re: nephro]
appleorange Offline
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Registered: 05/26/08
Posts: 157
Nephro, the anti-depressant effects of Nardil are so strong that they negate or prevent Clonazepam from making you feel depressed.

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#842225 - 02/09/09 06:20 AM Re: do antidepressants really work? [Re: appleorange]
pillar Offline
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Registered: 11/07/06
Posts: 1908
Loc: The Doors of Perception
Speaking of MOA Inhibitors, here's an article I found that backs your assertion appleorange http://www.mdpsych.org/SP99_dGoodman.htm

It's a bit dated, but not so dated that I won't bring it to my Dr.'s attention, this Wed.
_________________________
"God deliver us from such criminal imbecility."

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#842247 - 02/09/09 08:14 AM Re: do antidepressants really work? [Re: pillar]
RedBeetle Offline
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Registered: 01/26/09
Posts: 995
Loc: I forgot
From my experiences, with the what seemed like 10 or more depression medications, when starting the medication I would be super anxious...total opposite of what my MD told me the medication would do. He would tell me give it time or up the dosage! UGHHHH! After the anxiety finally wore off, I would eventually find myself depressed. Yeah, weird stuff, but that is how I reacted. I was told I was depressed before with GAD(general anxiety disorder). Well, I had never been depressed until I took the medication. Not sure if this is breaking the Rules, but here are all the meds I was tried on over several years...prozac, zoloft, lexapro, effexor er, cymbalta, celexa, and paxil from what I can remember.
In my case paxil was the worst on making my anxiety worse...not that it will someone else! It has worked great on others!
Zoloft...I was on it the longest and I fell into a deep depression on this med...to the point where I just didn't care about nothing! Not everybody will experience this, as everyone is different!
Celexa seemed the same as the zoloft and the lexapro as well
The effexor er...I felt like I was given speed, seriously it worked differently than all the rest, but it was just too much for me....I already had anxiety out the roof...so not for me!
cymbalta and prozac....they made me anxious, not as bad as the others, but I started getting depressed.
Finally my doctor realized that I didn't have GAD alone. I have a panic disorder with some GAD...anxious, but sometimes in some situations I was going into full panic mode. I have social anxiety and agoraphobia....yeah, not as serious as those that you see locked away in their homes and scared to leave. I just don't like crowds...walmart, busy streets, elevators....I kept a journal of all my episodes and when they happened and what I was doing, who was around and time of day....basically as specific as I could be and finally after 8 years of suffering was diagnosed.

These medications have worked wonders for some people and are needed for some that refuse to get help, but if you are just having an off day every now and then you are probably not depressed. I have researched into these meds and well what I found is that those that are in need because of a chemical imbalance are usually those that are severely depressed...not wanting to get out of bed, suicidal idealization, not bathing, just don't care about nothing....but there are so many people that take these meds because their doctors think they are depressed....even if you have symptoms for a month on and off, more off than on(not talking about the suicidal thoughts), it could be you are having a bad month. As someone posted earlier, could it be something in your mind thinking the meds are working....and the studies showing placebo being just as effective...well, we all know the power of the mind works in mysteries ways. Those that have a positive way of thinking and try to look on the brighter side of things would probably think the medications are working, which in turn would show drastic change in their behavior...those that have a negative way of thinking....well, probably not going to work. My views on depression are a lot different than others. I am not trying to push my views onto anyone....I do believe there are some people with depression that do and will benefit from being medicated, but there are some that are being prescribed these medications that really don't need them.

I have to share this...I went to the ER once with a migraine. The doctor asks me how have you been feeling and I said my head is throbbing and I think I have to puke....my exact words. BTW I did puke, and he says you look like you are depressed. I looked awful been in the bed all day in the dark trying to rid myself of that demon of a migraine and puking in a garbage bag beside the bed. Sorry if TMI...it is funny to me now...lol I couldn't laugh or reply I just gave him a look. Next thing I know I am being prescribed prozac and of course a shot of something that knocked me out. I laughed later about the prozac....the guy didn't know me. He didn't know my history with migraines. He did know I had a mini stroke just a year prior to this migraine.

People make judgement calls...doctors do and so do nurses, but you know your body (or should) and when something isn't right or isn't working, you should write these things down and discuss them with your MD...they are just like everybody else(don't be afraid of your doctor, just be honest always). My doctor told me give them 4 to 6 weeks and then if no progress he would say give it 4 more weeks or he would up my dose and say give it 4 to 6 weeks, if initially it didn't work, then go onto the next med and so on....these are my experiences.....at this time I did not completely understand how to communicate with my doctor efficiently, I do now. I just keep up with everything and write it down and discuss it. After being correctly diagnosed and treated we had a good patient/doctor relationship and I realized he was like everyone else, no better. I agree there are few compassionate doctors in this world left. I am a nurse now....after getting being diagnosed and all the research I did on medications I decided to get out and do something with my life. I love people and am a believer in behavioral modification therapy. Sometimes it only takes retraining your way of thinking. Stay positive, even when things seem doom and gloom....somebody out there has it worse and some go through the same things daily. Be thankful for what you do have and focus more on the good....that is with me though and of course something for panic attacks, hoping someday they will just disappear completely! Positive thinking \:\)

For me, I did not and still do not need an antidepressant.
Everybody is different. Sometimes after a series of unfortunate events happen someone may need an antidepressant, just depends on the person and their coping mechanisms. If you have good coping mechanisms, then you should be fine, but as always if you even have the thought cross your mind of hurting yourself or others please go in and be seen by a MD or ER doctor. Get the help you need for yourself. Taking your own life is the most selfish thing anybody could ever do and it hurts those that love you more than you will ever know...even if you think they don't love you, like most that convince themselves of this, they do love you.

K, another rambling session....if I broke the Rules, sorry, just putting out my opinion...delete if I did.
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#842273 - 02/09/09 09:05 AM Re: do antidepressants really work? [Re: appleorange]
nephro Offline
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 Originally Posted By: appleorange
Nephro, the anti-depressant effects of Nardil are so strong that they negate or prevent Clonazepam from making you feel depressed.



Even more reason not to take it. Benzodiazepines can make comprehensive diagnosis difficult by masking it, as well as possibly causing dependence; MAOIs seem to be superior to SSRIs in terms of treating anxiety, especially at induction, though nervousness is an uncommon side-effect. Anxiety is a more common side-effect with the SSRIs.

Dawnmn, SSRIs are known for producing or exacerbating anxiety during induction. It is one of the more acceptable reasons for prescribing benzodiazepines in the short-term.

It is surprising that some doctors suggest to their patients that they might be depressed. The more the patient thinks they might be depressed, the more they probably will be depressed, or think they are, which is probably just as bad.



Edited by nephro (02/09/09 09:15 AM)

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#842276 - 02/09/09 09:20 AM Re: do antidepressants really work? [Re: RedBeetle]
pillar Offline
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Paxil and anxiety disorders do not mix. No matter what the literature says, Paxil is quite possibly the worst AD med, for people with dual diagnosis of depression and anxiety. That stuff made me violent and want to pull my hair out. Even with 3mg's of Klonopin/day, my anxiety level went through the roof!

Now, Prozac on the other hand, has all the appetite suppressant and energy boosting effects, of Paxil without the extreme anxiety. This may just be my experience but after 1 month of Prozac I'm beginning to come out of my shell and actually generally enjoying things again.

I was diagnosed with depression and medicated at age 12. I'm 32 now and often wonder if the medication, at such a young age, created my Refractory Depression? Sort of like treating strep with amoxicillin, from childhood and creating an amoxicillin resistant strain of strep from repeated or negligent use of meds. Of course this is just my own over analyzed opinion of my situation. I could be wrong?
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#842284 - 02/09/09 09:29 AM Re: do antidepressants really work? [Re: nephro]
pillar Offline
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 Originally Posted By: nephro
It is surprising that some doctors suggest to their patients that they might be depressed. The more the patient thinks they might be depressed, the more they probably will be depressed, or think they are, which is probably just as bad.



Nephro, I was told I was depressed and forced to take medication at age 12. To this day, I still feel I was just a normal kid. My parents had just divorced and I was always shy. A brilliant Psychiatrist diagnosed a 12 year old with a Borderline Personality Disorder and under threat of state hospitalization "enticed" me into taking anti-depressants. Because of that I will forever wonder "what if...?" and "was I really ill or was she( the Psychiatrist who years later I was subpeonaed to testify against and subsequently had her license to practice medicine pulled )?
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#842286 - 02/09/09 09:42 AM Re: do antidepressants really work? [Re: pillar]
nephro Offline
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I was just thinking about what to say to that, and trying to think of some justification, but still can't. How long had you had the symptoms for before they told you that you were depressed?

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#842296 - 02/09/09 10:15 AM Re: do antidepressants really work? [Re: pillar]
RedBeetle Offline
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Registered: 01/26/09
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 Originally Posted By: pillar
 Originally Posted By: nephro
It is surprising that some doctors suggest to their patients that they might be depressed. The more the patient thinks they might be depressed, the more they probably will be depressed, or think they are, which is probably just as bad.



Nephro, I was told I was depressed and forced to take medication at age 12. To this day, I still feel I was just a normal kid. My parents had just divorced and I was always shy. A brilliant Psychiatrist diagnosed a 12 year old with a Borderline Personality Disorder and under threat of state hospitalization "enticed" me into taking anti-depressants. Because of that I will forever wonder "what if...?" and "was I really ill or was she( the Psychiatrist who years later I was subpeonaed to testify against and subsequently had her license to practice medicine pulled )?



You just made me think of my soon to be 10 year old step son. His psychiatrist tried him on Lexapro....2 weeks later he said his stuffed animal came alive and tried to kill him, so he tore his arm off and made a noose with a shoe string and hung the armless stuffed animal by the neck from his brothers top bunk. He was ummm taken off that med immediately! OK, so the psych wanted to try risperadol, now my step son is also ADHD and then tenex(BP med) along with Vyvanse 70mg. This last visit the Vyvanse gets canceled, the tenex gets canceled. He is being tapered off the tenex, and now taking max dose of concerta 72 mg, upped the risperadol to 2mg @ night and then added wellbutrin xl 150 mg.....UGHHHH! He went through some really bad things with his mom. She abused him severely. He is emotionally scared from it all and trusts no one. He is very hard to get close to. He is so impulsive...breaking windows, starting fires, threatening to kill himself and other family members. The psych said give it time and if it doesn't work this time we are moving on to mood stabilizers....he shows signs of being bipolar, which some antidepressants can antagonize manic behavior. I am at my wits end and want to help him desperately. I know your case is different.

Oh and Nephro, they do suggest you may be depressed a lot! Especially when the SSRI's made it big. Research it and see how drug reps promoted to doctors to give out their samples and how they would give those doctors bonus' for having so many prescriptions written per year. Money, lavish vacations....and God only knows what else!

As I mentioned before some do need these medications. I don't like giving this child these meds, they are not approved for children for depression, but at this point I am grasping at straws, so he can find his inner peace. Behavior modification is working wonders with his brother, but the other is as stubborn as they come and such a witty boy, so bright, but he doesn't see himself like that. I remind him constantly of how smart he is, and all four of the children that they can be what they want to be. I just wish he would come around. My two girls are ADHD, but they don't act out at school and not even at home anymore, and have great grades, so not going to medicate them.
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#842356 - 02/09/09 12:09 PM Re: do antidepressants really work? [Re: nephro]
pillar Offline
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 Originally Posted By: nephro
I was just thinking about what to say to that, and trying to think of some justification, but still can't. How long had you had the symptoms for before they told you that you were depressed?


A few months. Best part is 2 years later I was hospitalized for depression and anxiety - not a Borderline Personality Disorder. The new shrink, at that time, told me I was suicidal even though I constantly denied it and hadn't thought of or felt it. This institution would place the suicide risks in orange jump suits, restrict their visitors and mail/phone contact, but never took any of those steps against me. I was so depressed and such a suicide risk that I didn't warrant any of the standard procedures or precautions. They based their entire diagnosis on an IQ/psych eval., my Mothers comments and my constant truancy from highschool. Again my shyness and social awkwardness (and extrodanary insurance ) landed me in the wrong place, for the wrong thing.

I learned a great deal of communication skills and how to lie and manipulate really well, while I was in there. Because of these early experiences, I have little faith in psychiatry and a great deal of difficulty trusting and therapist. Then there's the ever constant questioning of my own sanity due, in large part, to being told I was depressed and suicidal when I felt neither. It left me scarred emotionally and planted the seeds of self doubt, that stay with me to this day. Ain't life grand!?
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#842840 - 02/10/09 03:23 PM Re: do antidepressants really work? [Re: pillar]
nephro Offline
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Such a lot can change in the teenage years. Depression, invincibility, self-doubt, and all the range of feelings that come with wanting to shag every female in a short skirt.

What sort of effect can things like SSRIs have on a teenage boy going through all this, even if he does have other problems? I have no idea, but if it dampens them down, could it affect normal development? Kids that age can change their personality almost overnight, due to hormones, their friends, and things that happen in their life.

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#844434 - 02/13/09 08:15 PM Re: do antidepressants really work? [Re: nephro]
Opt_Out Offline
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Registered: 01/27/09
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most of my problems seem to be anxiety related, all ssri's have only made my axiety much worse.


Edited by Opt_Out (02/13/09 08:15 PM)

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#851390 - 02/28/09 12:22 PM Re: do antidepressants really work? [Re: pillar]
Lexi2006 Offline
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Registered: 01/15/09
Posts: 8
This forum is not to discuss suppliers. This thread is to discuss antidepressants and not the companies offering it.

Thanks for your support


Edited by Melody (03/03/09 07:21 AM)

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#851463 - 02/28/09 02:51 PM Re: do antidepressants really work? [Re: Lexi2006]
nephro Offline
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Amitriptyline has always been as effective as the newer drugs; the side-effect profile is the reason it fell out of favour. It certainly helps sleep and appetite. Now (along with dosulepin) it is not recommended for depression. I am assuming this is because of potential heart problems and/or high overdose risk.

Still, if you have been on it for a while, it may be worth staying on it, but it's worth also trying to get a doctor's opinion if possible.

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#902793 - 07/01/09 10:52 AM Re: do antidepressants really work? [Re: lazyscience]
MissFran Offline
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Registered: 06/29/09
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From what I've experienced, yes and no. They made my depression go away, but they also killed my sex drive and every other emotion I had besides depression/sadness. I felt very similar to a how I suppose a zombie would.
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#902813 - 07/01/09 11:29 AM Re: do antidepressants really work? [Re: MissFran]
salty1 Offline
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Registered: 03/13/06
Posts: 422
Loc: left coast
Your relationship with the psychiatrist is as important as the medication they prescribe. Sadly, most don't have time to really listen to you, the side effects your having, education about lifestyle etc. to make adjustments to meds or doses.

It's become "take this...see you in 30 days Buh-bye..."
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#903116 - 07/01/09 11:05 PM Re: do antidepressants really work? [Re: salty1]
NiceGuy Offline
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Registered: 12/05/08
Posts: 539
Loc: Up the Creek

Sadly, I must agree with Salty1.

Even if you find a psychiatrist with skills in talking therapy, they have become little more than drug salesmen, in America.
A 15 minute "Med Check" and out you go.

I came to regard it as "Stopping to get my ticket punched", by my drug dealer.

I recall the days when a psychiatrist appointment was generally 50 minutes and only 5 of those minutes were spent writing a prescription, maybe.
The majority of the time was talking about ones life and the Doctor offering insights, till one was able to develope "insight" of ones own.

Now, it's just "Take a happy pill" and come back in 30, 60 or 90 days.

There is no "Cure or Healing" expected. Just take these pills from now on.
It's as though psychiatry has given up on healing and is only treating the symtoms?
And why not ? They have an endless supply of patients, this way.

The news today is that the FDA is going after Benzo's, as well as Opiods.

In 10 to 20 years, I believe the FDA will be going after SSRI's as an experiment that failed the majority, (but made big money for big pharma).

Just one persons experiences over a long time.
If the SSRI's are working for others, good for you !

Cheers

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#903390 - 07/02/09 01:27 PM Re: do antidepressants really work? [Re: NiceGuy]
Khilee Offline
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Well said and true, NiceGuy. My Dr. had given me Xanax for anxiety caused by chronic pain. After a few months, he asked if I would care to see a psychiatrist because he was only able to give them to me for a few months. He said psychiatrists were better equipped to give those kinds of meds. The first visit was pretty long. He changed my antidepressant from Lexepro to Cymbalta and prescribed Dalmane, a sleeping pill, and added Xanax xr to the regular Xanax. After that, he asked a few questions, said "see you in 3 months" and I was out in 15 minutes.
K

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#903443 - 07/02/09 02:56 PM Re: do antidepressants really work? [Re: Khilee]
salty1 Offline
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Registered: 03/13/06
Posts: 422
Loc: left coast
In General - In patient acute psychiatric facilities aren't so much treatment, as they are places to warehouse someone either until they are no longer a threat to themselves,gravely disabled or their insurance runs out.

Emergency rooms workers often ask (behind closed doors) about the patients "wallet biopsy" in terms of prognosis. Cynical but true.

What's more, insurance panels often pay Ph.D.'s only $10 an hour more then masters level therapists. The big money makers? Psychiatrists...much cheaper to see someone once a month for 15 minutes then once a week for an hour.

Prozac = cheap. Psychotherapy = expensive.


Edited by salty1 (07/02/09 03:00 PM)
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#903494 - 07/02/09 04:40 PM Re: do antidepressants really work? [Re: salty1]
OldandWorn Offline
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That is where I met Popo and the love story began.
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#903496 - 07/02/09 04:47 PM Re: do antidepressants really work? [Re: OldandWorn]
Ballerina59 Offline

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So when is the wedding? rofl5 Seriously, Prozac has helped me through some very trying times, esp. when my Dad was on life support and after his death.

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#903775 - 07/03/09 10:34 AM Re: do antidepressants really work? [Re: NiceGuy]
ghost Offline
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Registered: 06/29/02
Posts: 175
Loc: Southeastern US
I agree with Salty1 and NiceGuy. SSRI's did nothing for me. The worst of them- the SNRI's made me feel like I was on speed. It was horrible. I had the worst case of road rage and could not sleep at all. I'm taking a little Zoloft to appease my psychiatrist so she'll give me Klonopin without feeling like a drug dealer, but it is useless. Total placebo. At least it doesn't have terrible side effects. Just nothingness. I'd give a lot to find an antidepressant that really worked.

Question: does anyone know anything about the new drug Proticq (I know I spelled it wrong). It's an SNRI. I've been seeing the literature for it scattered around doctor's offices.

Ghost
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#903911 - 07/03/09 03:48 PM Re: do antidepressants really work? [Re: ghost]
nephro Offline
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If you mean Pristiq (desvenlafaxine), it's just the main metabolite of Efexor (venlafaxine). So you might as well be taking Efexor. The only people that disagree with this are the people at Wyeth.

Oh yes, and it just came out when the patent for Efexor was about to expire.

Wyeth have been trying to get it approved for post-menopausal symptoms, as an excuse to get it on the market.

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#904400 - 07/05/09 10:05 AM Re: do antidepressants really work? [Re: toddz]
stressedout Offline
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Originally Posted By: toddz
if you have had to go through the frustration of new meds time and time again without positive results, waiting for the benefits and trying to cope with the side effects, you might take a more cynical view of antidepressants, as i do. many pple do struggle literally yrs trying to find the best combination, and go through several doctors as well. some do hit a combo that works, many others never do, and struggle with finding some relief before its to late.

ive yet to find a doc that really was concerned or cared for that fact. to them, its like...well lets try this one next. big deal they arent coping with major depression symptoms.

as i said, they help some pple and many others are left meds that provide them little or no relief. i hope in the future there will be some alternatives to the antidepressants we have available now.

quoting g.w. bush...now that made me laugh.

"I'm telling you there's an enemy that would like to attack America, Americans, again. There just is. That's the reality of the world. And I wish him all the very best." --George W. Bush, Washington, D.C., Jan. 12, 2009



Were you seeing a regular MD or a Psychiatrist? I don't trust a PCP to figure out the best antidepressant or antianxiety medicine for me. If I have major issues, I see my Psychiatrist, as my PCP has advised. After all that's what they are trained for. PCPs are general practioners and only know so much about mental health disorders. I had begged my pcp to be my therapist, my doctor is wonderful and sat with me for over an hour while I explained why I was so sad and how certain things that happened I didn't understand. My doctor explained some of the reasons I felt like I did or why some experiences helped but said that's as far as their training goes and I would be better off with a therapist.

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#905676 - 07/08/09 06:13 PM Re: do antidepressants really work? [Re: stressedout]
Cryptodiran Offline
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I know people who say antidepressants work for them. I tried several and none worked for me. Cymbalta made me feel like I was on speed and I did not like it. Others just didn't work at all. I also didn't like the fact that they prevent reuptake of neurotransmitters so your brain slows its production leaving you low on seratonin or dopamine(for example) making it difficult to stop taking them.
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#924335 - 09/01/09 06:53 AM Re: do antidepressants really work? [Re: Cryptodiran]
mouse23 Offline
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Registered: 08/29/09
Posts: 93
Loc: Mn
I had taken about a dozen different varieties of antidepressants over a 8 year period--and none of them had done me any good at all. I gave up on ever finding the right head-meds, until I met a girl for whom I have infinite respect--and she told me that it took her doctors 15 years(!!!) to find the right cocktail for her. On her recommendation I tried one more time---and got lucky. The very next thing I tried woked. Not just worked but changed my whole outlook on life. I had always had this hole inside I was trying to fill--with girls, drugs, or money--and finally it was patched.****************************************************************Many people don't believe in anti-d drugs because the doctors themselves can't rightly explain what they do--and thus are just as in the dark as you---but believe me--its a matter of learning to listen to your body and then finding one that works. Its entirely possible that NOTHING will work for you--but unlikely. (situational depression can still occur even when you have conquered other depression issues). Doctors are basically throwing a dart at a board blindfolded ("well, lets try this!"). Thats where you come in---tell them if you aren't 'feeling it'. And keep trying until you do.***************************************I assure you that the effect I get from my meds is no more placebo than the sense of well being you get from an opiate. It is a very real and tangible effect. If I go off my meds for a week or two--my life is balls.----I've done enough trial and error experimentation in the matter to be completely sure of what is causing the behavioral and psychological changes that occur when I go off my meds (I have even gone off them without knowing I was going off them--and got extremely depressed w/o knowing why---long story)************************************people who do not have depression, and people who have had bad luck with anti-depressants--will sometimes try to dissuade you from even trying--don't let them. My life was changed forever in the most positive way possible by finding the correct meds. The only thing to liken it to is a religious experience---the whole world was a hellish nightmare; and it was repaired by finding the right cocktail...(its all a matter of perspective after all---why not improve your perspective?)

(and no---I'm not any kind of rep for the drug companies--I find their practices despicable--but their products beneficial)
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#924336 - 09/01/09 07:03 AM Re: do antidepressants really work? [Re: pillar]
mouse23 Offline
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Registered: 08/29/09
Posts: 93
Loc: Mn
Originally Posted By: pillar
Originally Posted By: nephro
It is surprising that some doctors suggest to their patients that they might be depressed. The more the patient thinks they might be depressed, the more they probably will be depressed, or think they are, which is probably just as bad.



Nephro, I was told I was depressed and forced to take medication at age 12. To this day, I still feel I was just a normal kid. My parents had just divorced and I was always shy. A brilliant Psychiatrist diagnosed a 12 year old with a Borderline Personality Disorder and under threat of state hospitalization "enticed" me into taking anti-depressants. Because of that I will forever wonder "what if...?" and "was I really ill or was she( the Psychiatrist who years later I was subpeonaed to testify against and subsequently had her license to practice medicine pulled )?


I had the opposite happen--my parent did not believe in depression or anti-depressants--even though I was so miserable that I eventually started to self medicate with every street drug I could lay my hands on...I wonder what would have happened if I hadn't wasted 20 years feeling like sh it and instead had just started the head-meds in the 6th grade.

I have lucked out--and my own son doesn't seem to have inherited any of my mental problems (even after his mom died). But if he does--while I would first try whatever non-medicinal solutions I could think of first; I would not hesitate to have him on meds if it was the only way (and believe me, brother---for me it is the only way---I'll be on these things until the day they no longer work, and I live in fear of that day.)
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#924350 - 09/01/09 07:58 AM Re: do antidepressants really work? [Re: mouse23]
meonlyits Online   content
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Registered: 08/23/09
Posts: 428
not for everyone but yes, a/d's do work.
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