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#811495 - 12/06/08 10:08 AM
Re: Ritilan---Methylphenidate
[Re: RZeta]
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Board Addict
Registered: 11/29/04
Posts: 333
Loc: Southeastern U.S.
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Hi RZeta, Regarding your post on April 21, 2005, I agree with several points you made about Ritalin, and, Adderall. You were right on the money, politically correct, about Shire US (formerly Richwood Pharmaceutical Company, Inc., Florence, Kentucky, who "reinvented" Adderall, from the original patent holder of "Obetrol" (Obetrol Pharmaceuticals Brooklyn, NY), as you correctly stated, the patent had ran out on "Obetrol", and to make some formulation changes, the motive was to make money, and yes, in 1994 Adderall took off like a rocket! (as you stated) The original formula for Obetrol also contained 4 different versions, of a Schedule II stimulant, (one ten (10 mg.) tablet contained the following: 2.5 mg. methamphetamine saccharate, 2.5 mg. of methamphetamine hydrochloride, 2.5 mg. of amphetamine sulfate, 2.5 mg. of dextroamphetamine sulfate. Obetrol 20 mg. (twenty milligrams) contained twice the potency. With the "new formulation of Adderall" one ten milligram tablet contains: 2.5 mg. dextroamphetamine saccharate, 2.5 mg. of amphetamine aspartate, 2.5 mg. of dextroamphetamine sulfate, 2.5 mg. of amphetamine sulfate. I started out on Ritalin as well, (14 yrs ago), then, 11 years ago, switched to 15 mg. of Dexedrine Spansules, with Adderall immediate release tablets, as a late afternoon booster. I have now mostly abandoned Adderall, and like you, use the generic dextroamphetamine sustained release versions, (Barr) to save money, as the Dexedrine brand name was so much more expensive. It is interesing to note the history of Ciba (who held the original patent to Ritalin) immediate release of methyphenidate, and the "Ritalin SR", as it has grown with "more improved versions of the sustained release methyphedidate" with the now "Ritalin LA capsules" in addition, for 3 versions of Ritalin from Novartis, (formerly Ciba) and the newer competitor, McNeil Pharma, with their version of methyphenidate "Concerta" (all extended release formulations), as the sustained release versions of Ritalin (methyphenidate) are geared especially for children and adolescents, who truly do have a balancing act with the up's and down's of the original formulation immediate release Ritalin, as I experienced a "crash" myself, as a middle-aged adult, about 3 times a day, thus I immediately discovered the need for a pocket "Pill Traveler" to carry on me 24/7 to have access to the stimulant "when I ran out of gas" (a more daunting task for a youngster). The original brand Ritalin or Mylan Generic, just didn't last but about 2 1/2 to 3 hrs max for me. I would go back to it, but only as a last resort, if the dextro isomer of the compound of d,l-amphetamine sulfate would be removed from the marketplace. One never knows in this changing world, as Smith-Kline, the patent holder of Dexedrine Spansule, has already removed their "gold standard" sustained release patented "Benzedrine" from the marketplace (within the past ten years) after being around approximately forty (40 yrs)! I have tried to abide by the Rules and not mention any IOP, NRPO, or ROP "suppliers", just the US based manufacturer's and a bit of history. Source: PDR's 1968, 1978, 1980, 1986, 1995, 2007. along with my personal history using prescription Ritalin vs. other prescription Schedule II meds for my A.D.D. diagnosis. Addressing "ToddZ" 10/10/08.....yes my psychiatrist had me on Ritalin 3 x 10 mg. every 4 hrs, plus, Norpramin (desipramine HCI) for one year (1996) due to a dual diagnosis of ADD and Dysthymia (low grade persistent depression) and to try to counter-balance the up & down mood swings I was experiencing at the time.
Edited by Ludes_Vet (12/06/08 10:32 AM)
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