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#728465 - 07/15/08 01:54 PM
Re: Alprazolam
 
[Re: Oxy80]
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Pooh-Bah
Registered: 07/04/07
Posts: 1179
Loc: Great Patriot Awakening
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#768977 - 09/19/08 09:09 PM
Re: Alprazolam
[Re: latus0514]
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Board Addict
Registered: 02/08/05
Posts: 374
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As usual, nephro is correct. I also agree with breaking it up. Tolerance will build up quickly, and it's a very addicting drug, especially at 2mgs per dosage. It is also hell to detox. Withdrawals are terrible (I want to use a stronger word, but don't want to get banned)! A word from someone who has been there, pls. be careful! Hell doesn't even come close to describing it. I went from 6mg/day for about 2-3 years and cold turkeyed it. My withdrawal from it lasted well over a month!!! 6mg is hell-o-lot. I have no doubt withdrawing from it was pure hell for a month, but can you describe what the withdrawals were like? Was it profuse shaking, sweating, and intense anxiety? I only ask because the withdrawals from opiates are very well described on this board and many other pieces of literature. All I hear about on this board is seizures from Xanax withdrawal. The medical literature says this is extremely rare. Again, I am not being confrontational, but rather just curious what high dosage benzodiazepine withdrawal is like, from a firsthand experience.
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#773589 - 09/26/08 06:14 PM
Re: Alprazolam
[Re: diva24]
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Enthusiast
Registered: 08/28/08
Posts: 235
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[quote=jennygirl]Which brings up my question, does anyone have experience with the extended/sustained (not sure of the difference) release forms of xanax? I'm wondering if there would still be a need to taper from the regular form if you switched to an extended release. The sustained release probably wouldn't be a good choice for tapering because you can't cut the pills up without defeating the time release coating. Also, do you really need to be sedated for 12-24 hours if these are just for sleep? Extended release is going to make dependence more likely since it's the same thing as taking a xanax every few hours throughout the day. You could switch to regular xanax or cross taper to valium if/when you decide to taper. Here's a couple sites that sell the generic alprazolam SR (sustained release), I can probably dig up a few more if you want. http://www.visapharmacy.com (india) http://www.relaymeds.com (india) http://www.rxvogue.com (romania) Have you tried temazepam or nitrazepam which are older, longer acting hypnotic sleep aids? What about Lunesta or Sonata?
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#778371 - 10/04/08 07:44 AM
Re: Alprazolam
[Re: formula41]
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GRAND Pooh-Bah
Registered: 09/04/06
Posts: 10246
Loc: NOT 40!
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I would have thought that for a panic attack, speed of onset is more important than overall potency. There would be no point taking a very strong dose of clonazepam, for example, as its onset is too slow.
Diazepam is supposed to be the most rapid-acting of the commonly used benzodiazepines; some people say alprazolam is also rapid. But in either case, it's going to take 15 minutes at best for either of these pills swallowed on an empty stomach.
Some people have reported a quicker onset of various benzodiazepines by taking them sublingually. Either way, the only totally satisfactory way of aborting panic attacks, somewhat like epileptic seizures, very quickly, is by IV injection.
Buccal midazolam is used in the UK (as a liquid) to abort seizures quickly, and compares favourably with rectal diazepam tubes. It would seem a candidate for use in panic attacks, where there could be danger for the patient, and less likely, those around him.
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#786803 - 10/17/08 06:24 PM
Re: Alprazolam
[Re: kserah]
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GRAND Pooh-Bah
Registered: 09/04/06
Posts: 10246
Loc: NOT 40!
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I remember asking someone if Xanax-XR (nice of them to introduce yet another abbreviation for extended-release) was similar clonazepam. One person said it wasn't and two or three people said it was: http://www.epharmacywatch.com/freeboard/ubbthreads.php/ubb/showflat/Number/727196/#Post727196Not wanting to name anyone, but a few of those participating in the discussion have since been banned, though at least one of them is probably back under another name. It was slightly off-topic, so maybe it's worth starting a thread on modified-release alprazolam? The drug in its immediate release form has helped some people with panic situations, but caused one hell of a lot of problems for others. It was the first thing that hit me when I started reading the board: how many people were dependent, misusing or withdrawing from alprazolam. With this in mind, it would seem at first glance that the SR version may address these problems to some extent, but looking at the attached graph it also loses the advantage of rapid onset compared to the IR version, which is something I assumed would be the case due to the timed-release mechanism. The graph also points out the ups and downs of the IR drug as you mention. Indeed, looking at the graph it may resemble clonazepam or even be longer-acting. If the two drugs prove to be very similar, I would feel that clonazepam would be superior because it has less abuse potential, assuming the timed-release mechanism of Xanax-XR can be defeated. I think that the only way to find out is to let people feed back to us. The graph is from the manufacturer, and quite proudly shows a 6mg/day dose. As such, there's no wonder doctors are prescribing these amounts.
Attachments
Edited by nephro (10/17/08 06:36 PM)
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#787765 - 10/19/08 03:32 PM
Re: Alprazolam
[Re: nephro]
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Enthusiast
Registered: 08/28/08
Posts: 235
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