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#296717 - 02/09/06 06:39 PM
Re: Oxycodone
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Stranger
Registered: 01/26/06
Posts: 16
Loc: FL
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Cuddles,
That would really depend on how long he was taking it. I have been on oxycodone for almost 15 years so in my opinion, I would say no. But, if I think really hard back to when I had taken a 5mg oxycodone the very first time, it worked like magic.
I would never have believed in a million years that I would ever be prescribed 180 10mg percocet a month, just for breakthrough pain.
It did take a long time to build up the tolerance though. I was on oxycontin for a short period of time but my tolerance to that just skyrocketed so quickly that I had to switch to something else. It is really strange as both are made from the same stuff.
But for some reason the oxycodone aka percocet, has been my life saver. After 15 years of chronic illness, it still works for me, albeit at a larger dose. All the other schedule II long acting meds never lasted me more than a year or 18 months at best before I maxed out due to tolerance.
Everyone is different of course. But I would think if he was never a pain medication user, the oxycodone would be pretty strong for him. I would think they would be able to monitor it by his blood pressure. My doctor can tell immediately how I am feeling the days I see him by my bp. When my pain kicks in my bp goes way up.
I hope he is as pain free as humnaly possible. No one should ever suffer needlessly.
All the best,
Shayne
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#296721 - 02/10/06 07:25 AM
Re: Oxycodone
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GRAND Pooh-Bah
Registered: 10/27/03
Posts: 2164
Loc: Bearing Strait Ice/Land Bridge
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Quote:
I'm sure that's true, but it seems to me, unless someone is on hospice (i.e. a doc has issued an opinion that they have 6 mos. or less to live), OC is not prescribed. That's cause docs are pretty confident they won't get sued 'cause some addict got his clammy hands on the drug, crushed it, got a 12-hour dose in one snort, then dropped dead. What irks me is that OC was made for people with chronic mild to severe pain, and per the discussion thread above, there are no long-term side effects ('cept for addiction, which is an individual variable). Anyway - I know there must be some docs in this land of the free who will prescribe it (when justified) - just wish I knew where they are... Does anyone have any recommendations for alternate meds w/like effectiveness and no dopey side effects (that do not contain codeine, which gives me a headache)? Thanks for the feedback. So glad I stumbled upon this site.
S - Have you checked out the VIP side to this site? There is a section there that includes listings for sympathetic and some not-sympathetic doctors and pain clinics for various regions of the U.S.
Also, there are plenty of other internet locations where one can discuss the possibility and whereabouts of sympathetic doctors.
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#296727 - 03/01/06 01:03 PM
Re: Oxycodone
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Stranger
Registered: 01/03/02
Posts: 8
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Quote:
There are plenty of long term risks with abusing oxy's. Prison being one of them, and that can most certainly lead to bodily harm. Not to mention destroying your life, losing your family, career... Having no friends left, no one else left to turn too when you hit rock bottom, and then, well, that is the ultimate long term damage. Actively engaged addicts will never want to get better - as the drug is still working. Unfortunately, aside from jail time, your friend isn't gonna get a wake up call until it is too late. Cheers!
You obviously have NO idea what you're talking about. Prison is the ONLY valid risk of opiate-use you offer. And that's not the drug's fault. It's the fault of narrow minds like yours.
I started using opiates to treat clinical depresion when it struck me mid-life, over 8 years ago. It (an opiate) is the ONLY medicine I tried that helped (and I tried them ALL).
All of the so-called "anti-depressants" offered to me made me violent and "stupid." They nearly destroyed my life... in less than a year of experimentation (at the hands of several "doctors").
I don't get any kind of "high" or "buzz" from opiates; I just feel normal again - like I did before the depression struck me down. I'm now able to function again and offer something to society. I almost lost my business, friends, and family before finding this wonder drug (not "Oxy's", but an opiate).
Unfortunately, doctors can no longer prescribe opiates for depression. WHY NOT? They did for hundreds of years.???
That's BEACUSE the pharnaceutical compnaies can't patent opiates. They can't charge $15 a pill for it! So they fill our congressmen's heads full of nonsense like yours (and their pockets with lots of $$$) to outlaw the prescription of opiates for depression.
Opiates haven't destroyed my life, they've saved it. Nor have I lost my family or career. In fact, the depression and/or the "legitimate" prescription drugs that doctors shoved down my throat nearly did that for me.
Having no friends left???? I have more friends than ever... and nobody suspects I'm an "addict" (Oooooh....) .
I DID hit "rock bottom", yes.. .BEFORE I discovered opiates. Lucky for me, I did my research and I found a "CURE" that helped me climb back out of that hole and get back to leading a productive, happy, and HEALTHY life... WITHOUT any long-term liver or brain damage like the pharmaceutical companies offered me.
Please do your research before "spouting off" about issues you have no understanding of. And PLEASE don't run for public office.
It's uninformed, narrow-minded, arrogant people like you that have made "criminals" out of people like me... while helping the REAL CRIMINALS -- the murderous pharmaceutical companies -- make billions of dollars a year off "patentable" drugs, and in the process, cause long-term physical and psycholoigcal damage, destroying millions of innocent lives and families each year.
You also wrote: "Actively engaged addicts will never want to get better...":
I can't speak for all opiate "addicts" but trust me when I tell you this: I AM BETTER. No thanks to people like you.
BTW: You forgot one other ignorant myth: That we crave more and more drugs and higher and higher doses (robbing liquor stores to support our habits, of course) until we untimately overdose and die.
Before condeming opiate "addicts" why don't you talk to all of the happy, healthy Effexor (Paxil, etc.) users about "addiction" and "hitting bottom." I'ver known a LOT of them. I've watched them suffer and die. Poor bastards.
Too bad you can't ask Benjamin Franklin if he regrets treating his depression with morphine.
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#296736 - 03/29/06 10:45 AM
Re: Oxycodone
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Banned" soliciting business for email source
Registered: 02/12/06
Posts: 106
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Quote:
Hitler was into methamphetamine,not morphine.
True.
Although, he was a big fan of CODEINE. He had a lot of gastrointestinal problems due to the back and forth affects of abusing methamphetamine, then codeine, then meth, then codeine...etc.
On another note, Hitler wasn't (for the most part) aware of exactly WHAT he was being given. Hitler kept his personal doctor very close to him, and most of Hitlers other advisors were not aware of what was going on. Watch one of the History Channel specials on Hitler's doctor, they go pretty in-depth.
Also, at the end of his reign, Hitler developed a 'parkinsons shake' in one of his arms, possible due to the amphetamine abuses.
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#296738 - 04/04/06 02:29 PM
Re: Oxycodone
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Board Addict
Registered: 12/25/03
Posts: 320
Loc: Capital of the Republic of Tex...
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LDN enhances oxycodone's analgesia Pharmacol Biochem Behav. 2005 Oct;82(2):252-62. Epub 2005 Sep 21. Related Articles, Links Click here to read Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in rats. Leri F, Burns LH. Department of Psychology, University of Guelph (Guelph, ON), Canada N1G 2W1. Ultra-low-dose opioid antagonists have been shown to enhance opioid analgesia and alleviate opioid tolerance and dependence. Our present studies in male Sprague-Dawley rats assessed the abuse potential of oxycodone+ultra-low-dose naltrexone (NTX) versus oxycodone alone. The lowest NTX dose (1 pg/kg/infusion), but not slightly higher doses (10 and 100 pg/kg/infusion), enhanced oxycodone (0.1 mg/kg/infusion) intravenous self-administration, suggesting a reduced rewarding potency per infusion. During tests of reinstatement performed in extinction conditions, co-self-administration of any of these three NTX doses significantly reduced drug-seeking precipitated by priming injections of oxycodone (0.25 mg/kg, s.c.), a drug-conditioned cue, or foot-shock stress. During self-administration on a progressive-ratio schedule, animals self-administering oxycodone (0.1 mg/kg/infusion)+NTX (1 pg/kg/infusion) reached a "break-point" sooner and showed a trend toward less responding compared to rats self-administering oxycodone alone (0.1 mg/kg/infusion). In the final experiment, the addition of ultra-low-dose NTX (10 pg/kg, s.c.) enhanced the acute stimulatory effect of oxycodone (1 mg/kg, s.c.), as well as locomotor sensitization produced by repeated oxycodone administration (7 x 1 mg/kg, s.c.). In summary, this work shows that ultra-low-dose NTX co-treatment augments the locomotor effects of oxycodone as it enhances opioid analgesia, but reduces oxycodone's rewarding potency and subsequent vulnerability to relapse. PMID: 16182352 [PubMed - indexed for MEDLINE] Psychopharmacology (Berl). 2005 Sep;181(3):576-81. Epub 2005 Oct 12. Related Articles, Links Click here to read Ultra-low-dose naltrexone suppresses rewarding effects of opiates and aversive effects of opiate withdrawal in rats. Olmstead MC, Burns LH. Department of Psychology, Queen's University, Kingston, Ontario, K7L 3N6, Canada. RATIONALE: Ultra-low-dose opioid antagonists enhance opiate analgesia and attenuate tolerance and withdrawal. OBJECTIVES: To determine whether ultra-low-dose naltrexone (NTX) coadministration alters the rewarding effects of opiates or the aversive effects of opiate withdrawal. METHODS: We used the conditioned place preference (CPP) and conditioned place aversion (CPA) paradigms to assess whether ultra-low-dose NTX alters the acute rewarding effects of oxycodone or morphine, or the aversive aspect of withdrawal from either drug. To assess the dose response for ultra-low-dose NTX, a range of NTX doses (0.03-30 ng/kg) was tested in the oxycodone CPP experiment. In order to avoid tolerance or sensitization effects, we used single conditioning sessions and female rats, as females are more sensitive to the conditioning effects of these drugs. RESULTS: Ultra-low-dose NTX (5 ng/kg) blocked the CPP to morphine (5 mg/kg) and the CPA to withdrawal from chronic morphine (5 mg/kg, for 7 days). Coadministration of ultra-low-dose NTX (30 pg/kg) also blocked the CPA to withdrawal from chronic oxycodone administration (3 mg/kg, for 7 days). The effects of NTX on the CPP to oxycodone (3 mg/kg) revealed a biphasic dose response. The two lowest doses (0.03 and 0.3 ng/kg) blocked the CPP, the middle dose (3 ng/kg) was ineffective, and oxycodone combined with the highest dose (30 ng/kg) produced a trend toward a CPP. CONCLUSIONS: Ultra-low-dose NTX coadministration blocks the acute rewarding effects of analgesic doses of oxycodone or morphine as well as the anhedonia of withdrawal from chronic administration. PMID: 16010543 [PubMed - indexed for MEDLINE]
_________________________
The no license, no insurance, no drivers license illegal alien who tried to insurance fraud me just lost.
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#296739 - 04/04/06 05:06 PM
Post deleted by Administrator
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Anonymous
Unregistered
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#296741 - 04/04/06 05:41 PM
Re: Oxycodone
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Enthusiast
Registered: 02/06/06
Posts: 238
Loc: Mobtown, USA
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Quote:
Rhino, you left a lot of people out of your hall of fame:
John Belushi--heroin and coke--1981, I think.
Nirvana's Curt Cobain, Marilyn Monroe, Janis Joplin, Jimmi Hendrix, Inxs lead dude, Robert Palmer, Jim Morrison, and how many others have I forgotten?
Chris Farley
_________________________
"Everything in moderation (Especially moderation)."
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#296743 - 04/05/06 06:51 AM
Re: Oxycodone
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Pooh-Bah
Registered: 10/24/04
Posts: 813
Loc: west/midwest
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Not to get off topic, but as a response- RE: the comment that the Nazis invented Methadone=
Methadone is a synthetic m-opioid receptor agonist that was developed more than 50 years ago. The circumstances surrounding its development have been, and perhaps still are, associated with an interesting myth. Methadone was said to have been developed in response to an order by Hitler to develop an alternative to morphine, which was in short supply at the end of World War II. The trade name Dolophine was said to have been derived from Hitler’s first name Adolph (Payte, 1991). The truth is that methadone was discovered at I.G. Farbendustrie at Hoechst-am-Main in Germany in the course of work on spasmolytic compounds during World War II. Because it lacked any resemblance to known compounds, its narcotic analgesic properties were not expected. Despite the morphine shortage, methadone was not used as an analgesic until the post-war period. It is believed that Germany’s failure to realize methadone’s value as an analgesic was because initial doses were too high and intolerable opioid side effects resulted (Chen, 1948). Concerning nomenclature, the more likely etymology is that Dolophine was derived from dolor for pain and fin for end (Payte, 1991) I checked several sources, this appears correct. J
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