Proglumide Therapy v1.0 - 11/07/2004

I will to my best to rewrite this guide, since it was lost after PW's problems with their ISP, so here goes. I was inspired to write this guide thanks to Missthang, and a few others who IMed me with questions about Proglumide. Several years ago I was having kidney stones, with painful urinary colics in between. I was taking 12-15 10mg of hydrocodone a day for almost 6 months, and I was able to reduce my tolerance to hydrocodone considerably (from 12 down to 5 for myself). Currently, The Dispensary sells a 30 pack of 400mg Proglumide for 68 bucks, which is more than enough for one "session" of Proglumide therapy, which is 5 weeks (21 pills total for one session). The pills will be broken in half, so one pill will be used a day. As for my credentials, I am a registered nurse, currently striving to achieve my CRNA (Certified registered nurse anesthesist).

Proglumide source: http://the-dispensary.com/comfiles/pages/141.shtml

Day 1-7
When you wake up: Start out the morning by taking 200mg of Proglumide, along with 75% of your normal hydrocodone dosage. Trust me, this is all you will need with the Proglumide...it's that good.
During the day: Take your normal dosages of hydrocodone, but try to skip one dosage through out the day. It's not going to be hard, since the Proglumide makes the hydrocodone last longer and work a lot more. (Example: Say you are taking 2 pills, 5 times a day. Try to eliminate one dosage where you would take 2 pills, 4 times a day.)
When you go to sleep: Before you're about to go to bed, take the other 200mg of Proglumide, along with 75% of your normal dosage of hydrocodone. Also, take an antihistamine such as Atarax/Vistaril (hydroxyzine) or Benadryl, or a stomach acid medicine such as Zantac or Tagamet. This will help to boost the hydro at night when you are asleep so you will be able to sleep throughout the night with out any disturbances.

Day 8-14
This week you won't be taking any Proglumide, because you can develop a tolerance to Proglumide as well...and we definitely do not want this to happen. By this time, you should be able to eliminate one of your dosages during the day now. (Example: Whereas you were taking 10 hydrocodone pills a day, you should now be able to make it with 8.) If you have a flareup with pain, try not to take any more hydrocodone. Boost it with an antihistamine or acid reducer as mentioned above. If nothing else will help the pain, you may take more hydrocodone. Remember, we're only trying to reduce your tolerance, not make you feel miserable; this is why we're on the painkillers in the first place!

Day 15-21
Repeat cycle from first week, etc.

As mentioned, one "session" is five weeks long, three of which you will be taking the Proglumide. This is a really effective drug for reducing your tolerance to hydrocodone, or any other painkiller for that matter. With this relatively simple guide you should be able to do just that. You may repeat the cycle again in approx. 2-3 months for reducing your opiate tolerance even more. I used 3 cycles of Proglumide therapy and was able to recide my tolerance by at least 50% after the third cycle.

I hope this guide can at least be a stepping stone for people who are interested in Proglumide therapy. If you have any questions, feel free to PM them my way, as I frequent this board several times a day. Hopefully this will benefit others, since everyone on PW has helped me out so much since I've been a member. Most of all, GOOD LUCK!

--bmurphr1

There is another source for Milid or proglumide - an int'l pharmacy called e-pharmacy.net - out of Australia I believe. Others have had success with this pharm, but I have a question. I ordered about a month ago, 10/10 exactly, and after a week, I received notification that the medication was shipped by Mail. I have not yet received anything to indicate that the Post Office has attempted to deliver or anything, and I only wonder because others received their orders in couple to a few weeks. I believe it was shipped, but what if the address was wrong. What does the U.S. post office do in that case. They have a name, but the address is wrong, do they attempt to redirect the package or mail to the correct address? Do they just leave it at the Post Office as undeliverable if they've attempted to deliver, or do they send it back to the sender as undeliverable? Anyone have any insight to this matter?

I ordered twice proglumide from e-pharmacy.net
They are out of Pakistan. Be careful, there are others with a similar name, such as epharmacy without the dash. Also note they end in .net. That place sent 400mg pills. I received my order in about 8 days both times with no problems.

Anyone know if proglumide works okay with codeine? I've used it in the past with hydro but wasn't sure whether it might interfere with the enzyme required for cod metabolism.

Also, any chance it would potentiate Tramadol? I'm guessing "no", but can't hurt to ask.

Thank you.

my best guess is that proglumide would be a safer and less dependance increasing enhancer than inhibiting CYP metabolism, since its just a CCK Peptide inhibitor. it wouldn't increase blood levels of the opioid, but rather hinder ONE mechanism of tolerance, the build up of CCK peptide, which is the body's anti-opioid. but there is no study i know of comparing the safty of the two.

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Also, any chance it would potentiate Tramadol? I'm guessing "no", but can't hurt to ask.

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Im guessing yes, it would, because part of Tramadol's mechanism is the same as any other painmed, Mu Opioid Agonist. For me Tramadol is very much an opioid but i think i have extensive 2D6 metabolism and metabolize a lot into M1. Tramadol's M1 metabolite is 200 times more of an opioid than Tramadol it's self. the other metabolites, generated by 3A4, are almost inactive in comparison according to my research.

I read somewhere else that a guy took one whole 400mg tab and it was much better than just taking a half of one. He also said that there was one report(and that's all I have found as I have researched the topic) that says you need to stop every other week.

So has anyone actually taken 400mg before, even if you havent, would there be any toxic effect by doing so, just in case I want to experiment. And has anyone just continually taken the milid?

I've seen people asking about Proglumide recently, and thus I wanted to bump this valuable thread up for anyone interested.

The proglumide I get are all 400mg.
I've always (well,I'll say 80 percent of the time) taken the whole 400mg tab).

I usually take it anywhere from 45 minutes to an hour before taking my opiate D.O.C.

I (personally) haven't noticed any ill effects in taking a whole 400mg tab.

I too would start out with 200mg and see how it works.
Remember tolerance builds quickly so if you start out with 200mg you'll either need to take breaks/vacations from it or increase the dosage.And knowing proglumide like I do, It may not be of any advantage by taking more as your tolerance starts to rise.

So you're probably better off taking the 200mg and take the vacations rather than increasing the dosage of the proglumide.

Ok, I want some.
Anyone have a reliable, current source for Proglumide?

I'm still working on it, but I'll let you know as soon as I find one...

I just put in a order for proglumide from e-pharmacy.net so I'll let you all know when I get it and if it works. I've read quite a bit about it and I'm surprised it's so hard to get.

Everything I've read seems to indicate it works. I'm currently taking around 100mg oxycodone daily and it's barely helping. On bad days I've gone as high as 150mg daily.

I really don't want to ask the doc to go any higher so I'm hoping the proglumide will help. I'd like to cut my consumption in half and still get relief.

I just received my order from e-pharmacy.net for proglumide (Milid). Susan was very helpful and even called me from Australia to place the order b/c I didn't feel comfortable e-mailing out my CC#. She said it would take 4-6 weeks and I received it in less than 30 days. I did have a lovely bright-red sticker on the package from the FDA which basically told me the meds were not US approved, but they were going to let me have them anyway...However don't expect that I would necessarily get any future orders.

I'll let you know my results from the tests in a couple months.

Brent, this is a very helpful guide; thank you.
And Splangy, I'd love to hear about your results.

Does anyone offer proglumide? I tried e-pharmacy.net but they don't respond to e-mails.

I cannot find a working source for proglumide. Can somebody please help?

Has anyone had any luck with a proglumide source?